Vaccin mot covid-19 (mRNA)
Vaccin mot covid-19 (mRNA)
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Comirnaty, Comirnaty JN.1, Comirnaty JN.1 (3 doser), Comirnaty Omi......
Comirnaty, Comirnaty JN.1, Comirnaty JN.1 (3 doser), Comirnaty Omicron XBB.1.5, Comirnaty Omicron XBB.1.5 (10 doser), Comirnaty Original/Omicron BA.1, Comirnaty Original/Omicron BA.4-5, Spikevax, Spikevax bivalent Original/Omicron BA.1, Spikevax bivalent Original/Omicron BA.4-5ATC-koder
J07BN01
J07BN01Substanser
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bretovameran, davesomeran, elasomeran, famtozinameran, imelasomeran, r......
bretovameran, davesomeran, elasomeran, famtozinameran, imelasomeran, raxtozinameran, riltozinameran, tozinameranBedömning
Inget tyder på att vaccinering mot covid-19 med mRNA-vaccin under graviditeten påverkar fosterutvecklingen eller graviditeten negativt. Det visar samstämmiga uppföljningar av ett stort antal vaccinerade gravida kvinnor. Vaccinet förs inte över till fostret. Däremot passerar de skyddande antikropparna som bildas efter vaccinationen över till barnet, som därmed också får ett skydd mot covid-19.
Gravida kvinnor som infekteras med covid-19 har en högre risk att bli svårt sjuka. De föder oftare för tidigt, drabbas i högre grad av allvarliga komplikationer som blodproppar och behöver oftare sjukhusvård. Folkhälsomyndigheten rekommenderar därför att alla gravida erbjuds vaccination med ett mRNA-vaccin efter vecka 12. Det går också bra att vaccinera före vecka 12, vilket rekommenderas om kvinnan har ytterligare riskfaktorer. Se länk till Folkhälsomyndigheten nedan.
Bakgrund
Vacciner delades tidigare in i inaktiverade vacciner som består av avdödade virus eller bakterier och levande vacciner som består av försvagade virus eller bakterier. Nyare vacciner framställs med annan teknik och innehåller t...... Visa hela bakgrundstexten
Referenser
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Pollard AJ, Bijker EM. A guide to vaccinology: from basic principles to new developments. Nat Rev Immunol. 2020;0(0):1-18.
EMA. EMA Public assessment report COVID-19 Vaccine Moderna. EMA [www]. [updated 2021-01-06, cited 2021-01-28].
EMA. EMA Public assessment report Corminaty. EMA [www]. [updated 2020-12-21, cited 2021-01-28].
Magnus MC, Örtqvist AK, Dahlqwist E, Ljung R, Skår F, Oakley L et al. Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes. JAMA. 2022. Online first.
Norman M, Magnus MC, Söderling J, Juliusson PB, Navér L, Örtqvist AK et al. Neonatal Outcomes After COVID-19 Vaccination in Pregnancy. JAMA. 2024;331(5):396-407.
Shimabukuro TT, Kim SY, Myers TR, Moro PL, Oduyebo T, Panagiotakopoulos L et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. N Engl J Med. 2021.
ENTIS. ENTIS Position Statement: COVID-19 vaccines in pregnancy and lactation. ENTIS [www]. [updated 2021-04-14, cited 2021-04-28].
Zauche LH, Wallace B, Smoots AN, Olson CK, Oduyebo T, Kim SY et al. Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion. N Engl J Med. 2021;385(16):1533-1535.
Magnus MC, Gjessing HK, Eide HN, Wilcox AJ, Fell DB, Håberg SE. Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage. N Engl J Med. 2021;0(0):0.
Blakeway H, Prasad S, Kalafat E2, Heath PT, Ladhani SN, Doare KL, Magee LA, O'Brien P, Rezvani A, von Dadelszen P, Khalil A . COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstet Gynecol . 2021 Aug 10;0(0):0.
Goldshtein I, Steinberg DM, Kuint J, Chodick G, Segal Y, Shapiro Ben David S et al. Association of BNT162b2 COVID-19 Vaccination During Pregnancy With Neonatal and Early Infant Outcomes. JAMA Pediatr. 2022 Feb 10;e220001. doi: 10.1001/jamapediatrics.2022.0001. Online ahead of print.
Fell DB, Dhinsa T, Alton GD, Török E, Dimanlig-Cruz S, Regan AK et al. Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes. JAMA. 2022. Online first
Prasad S, Kalafat E, Blakeway H, Townsend R, O'Brien P, Morris E et al. Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy. Nat Commun. 2022;13(1):2414.
Infpreg. Covid-19 [Kunskapscentrum för infektioner under graviditet] . Infpreg [www]. [updated 2021-01-10, cited 2021-01-28].
Karin Petterson, Lars Naver. Covid-19 hos gravida ofta lindrig – svår sjukdom kan dock uppstå. Läkartidningen [www]. Läkartidningen. [updated 2021-01-14, cited 2021-01-28].
Smith ER, Oakley E, Grandner GW, Ferguson K, Farooq F, Afshar Y et al. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Glob Health. 2023;8(1).
Socialstyrelsen. Bilaga till avsnittet om covid-19 under graviditet i delredovisning 3. Socialstyrelsen [www]. [updated 2021-04-29, cited 2021-11-08].
Socialstyrelsen. Bilaga till avsnittet om covid-19 under graviditet i delredovisning 5. Socialstyrelsen Dnr 57-4823/2021 [www]. [updated 2021-08-24, cited 2021-11-08].
Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, Harris T, Hawdon J, Morris E, Muller P, Waite L, Webster K, van der Meulen J, Khalil A. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol. 2021 May 20;225(5):522e1-522e11.
Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y et al. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Invest. 2021;131(13):e150319.
Zdanowski W, Waśniewski T. Evaluation of SARS-CoV-2 Spike Protein Antibody Titers in Cord Blood after COVID-19 Vaccination during Pregnancy in Polish Healthcare Workers: Preliminary Results. Vaccines (Basel). 2021;9(6):675.
Halasa NB, Olson SM, Staat MA, Newhams MM, Price AM, Pannaraj PS et al. Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants. N Engl J Med. 2022;387(2):109-119.
Jorgensen SCJ, Drover SSM, Fell DB, Austin PC, D'Souza R, Guttmann A et al. Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy. JAMA Pediatr. 2023 Oct 23. doi: 10.1001/jamapediatrics.2023.4499. Online ahead of print.
- Pollard AJ, Bijker EM. A guide to vaccinology: from basic principles to new developments. Nat Rev Immunol. 2020;0(0):1-18.
- EMA. EMA Public assessment report COVID-19 Vaccine Moderna. EMA [www]. [updated 2021-01-06, cited 2021-01-28].
- EMA. EMA Public assessment report Corminaty. EMA [www]. [updated 2020-12-21, cited 2021-01-28].
- Magnus MC, Örtqvist AK, Dahlqwist E, Ljung R, Skår F, Oakley L et al. Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes. JAMA. 2022. Online first.
- Norman M, Magnus MC, Söderling J, Juliusson PB, Navér L, Örtqvist AK et al. Neonatal Outcomes After COVID-19 Vaccination in Pregnancy. JAMA. 2024;331(5):396-407.
- Shimabukuro TT, Kim SY, Myers TR, Moro PL, Oduyebo T, Panagiotakopoulos L et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. N Engl J Med. 2021.
- ENTIS. ENTIS Position Statement: COVID-19 vaccines in pregnancy and lactation. ENTIS [www]. [updated 2021-04-14, cited 2021-04-28].
- Zauche LH, Wallace B, Smoots AN, Olson CK, Oduyebo T, Kim SY et al. Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion. N Engl J Med. 2021;385(16):1533-1535.
- Magnus MC, Gjessing HK, Eide HN, Wilcox AJ, Fell DB, Håberg SE. Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage. N Engl J Med. 2021;0(0):0.
- Blakeway H, Prasad S, Kalafat E2, Heath PT, Ladhani SN, Doare KL, Magee LA, O'Brien P, Rezvani A, von Dadelszen P, Khalil A . COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstet Gynecol . 2021 Aug 10;0(0):0.
- Goldshtein I, Steinberg DM, Kuint J, Chodick G, Segal Y, Shapiro Ben David S et al. Association of BNT162b2 COVID-19 Vaccination During Pregnancy With Neonatal and Early Infant Outcomes. JAMA Pediatr. 2022 Feb 10;e220001. doi: 10.1001/jamapediatrics.2022.0001. Online ahead of print.
- Fell DB, Dhinsa T, Alton GD, Török E, Dimanlig-Cruz S, Regan AK et al. Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes. JAMA. 2022. Online first
- Prasad S, Kalafat E, Blakeway H, Townsend R, O'Brien P, Morris E et al. Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy. Nat Commun. 2022;13(1):2414.
- Infpreg. Covid-19 [Kunskapscentrum för infektioner under graviditet] . Infpreg [www]. [updated 2021-01-10, cited 2021-01-28].
- Karin Petterson, Lars Naver. Covid-19 hos gravida ofta lindrig – svår sjukdom kan dock uppstå. Läkartidningen [www]. Läkartidningen. [updated 2021-01-14, cited 2021-01-28].
- Smith ER, Oakley E, Grandner GW, Ferguson K, Farooq F, Afshar Y et al. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Glob Health. 2023;8(1).
- Socialstyrelsen. Bilaga till avsnittet om covid-19 under graviditet i delredovisning 3. Socialstyrelsen [www]. [updated 2021-04-29, cited 2021-11-08].
- Socialstyrelsen. Bilaga till avsnittet om covid-19 under graviditet i delredovisning 5. Socialstyrelsen Dnr 57-4823/2021 [www]. [updated 2021-08-24, cited 2021-11-08].
- Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, Harris T, Hawdon J, Morris E, Muller P, Waite L, Webster K, van der Meulen J, Khalil A. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol. 2021 May 20;225(5):522e1-522e11.
- Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y et al. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Invest. 2021;131(13):e150319.
- Zdanowski W, Waśniewski T. Evaluation of SARS-CoV-2 Spike Protein Antibody Titers in Cord Blood after COVID-19 Vaccination during Pregnancy in Polish Healthcare Workers: Preliminary Results. Vaccines (Basel). 2021;9(6):675.
- Halasa NB, Olson SM, Staat MA, Newhams MM, Price AM, Pannaraj PS et al. Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants. N Engl J Med. 2022;387(2):109-119.
- Jorgensen SCJ, Drover SSM, Fell DB, Austin PC, D'Souza R, Guttmann A et al. Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy. JAMA Pediatr. 2023 Oct 23. doi: 10.1001/jamapediatrics.2023.4499. Online ahead of print.
Författare
Katarina Wide, Ulrika Nörby och Birger Winbladh för Region Stockholm.
Katarina Wide, Ulrika Nörby och Birger Winbladh för Region Stockholm.Uppdaterat
Innehållet uppdaterat 2/20/2024
Uppgifterna från födelseregistret är hämtade 4/1/2020
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Vaccin mot covid-19 (annat än mRNA)
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Infpreg [Kunskapscentrum för infektioner under graviditet]. Covid-19.
Folkhälsomyndigheten. Vägledning och fördjupad information om vaccination mot covid-19
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