12/21/2025

Janusmed fosterpåverkan

Janusmed fosterpåverkan – dexametason

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

För att komma till startsidan för Janusmed fosterpåverkan och för att göra sökningar klicka här.

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Dexametason – ögonpreparat

Dexametason – ögonpreparat

Klass : 2

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  1. Läkemedelsverket. Dexafree Produktresumé. Läkemedelsverket [www]. [updated 2018-09-17, cited 2025-12-17].

  2. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.

  3. Weijtens O, Schoemaker RC, Romijn FP, Cohen AF, Lentjes EG, van Meurs JC. Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate. Ophthalmology. 2002;109(10):1887-91.

  4. Martinez CE, Zhang D, Conway MD, Peyman GA. Successful management of ocular toxoplasmosis during pregnancy using combined intraocular clindamycin and dexamethasone with systemic sulfadiazine. Int Ophthalmol. 1998;22(2):85-8.

  5. Concillado M, Lund-Andersen H, Mathiesen ER, Larsen M. Dexamethasone Intravitreal Implant for Diabetic Macular Edema During Pregnancy. Am J Ophthalmol. 2016;165:7-15.

  6. Capuano V, Serra R, Oubraham H, Zambrowski O, Amana D, Zerbib J et al. DEXAMETHASONE INTRAVITREAL IMPLANT FOR CHOROIDAL NEOVASCULARIZATION DURING PREGNANCY. Retin Cases Brief Rep. 2019;13(4):300-307.

  1. Läkemedelsverket. Dexafree Produktresumé. Läkemedelsverket [www]. [updated 2018-09-17, cited 2025-12-17].
  2. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.
  3. Weijtens O, Schoemaker RC, Romijn FP, Cohen AF, Lentjes EG, van Meurs JC. Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate. Ophthalmology. 2002;109(10):1887-91.
  4. Martinez CE, Zhang D, Conway MD, Peyman GA. Successful management of ocular toxoplasmosis during pregnancy using combined intraocular clindamycin and dexamethasone with systemic sulfadiazine. Int Ophthalmol. 1998;22(2):85-8.
  5. Concillado M, Lund-Andersen H, Mathiesen ER, Larsen M. Dexamethasone Intravitreal Implant for Diabetic Macular Edema During Pregnancy. Am J Ophthalmol. 2016;165:7-15.
  6. Capuano V, Serra R, Oubraham H, Zambrowski O, Amana D, Zerbib J et al. DEXAMETHASONE INTRAVITREAL IMPLANT FOR CHOROIDAL NEOVASCULARIZATION DURING PREGNANCY. Retin Cases Brief Rep. 2019;13(4):300-307.
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Dexametason – systemiskt och för lokal injektion

Dexametason – systemiskt och för lokal injektion

Klass : 2

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  1. UK Teratology Information Service (UKTIS). USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY. UKTIS [www]. [updated 2023-07-01, cited 2025-12-17].

  2. Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgård BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study. BMC Med. 2023;21(1):140.

  3. Bay Bjørn AM, Ehrenstein V, Hundborg HH, Nohr EA, Sørensen HT, Nørgaard M. Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther. 2014;21(2):73-80.

  4. Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183(7):796-804.

  5. Xiao WL, Liu XY, Liu YS, Zhang DZ, Xue LF. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017;69:99-105.

  6. Reprotox. Prednisolone. Micromedex [www]. [cited 2023-02-08].

  7. Hellgren K, Secher AE, Glintborg B, Rom AL, Gudbjornsson B, Michelsen B et al. Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark. Rheumatology (Oxford). 2022;61(9):3711-3722.

  8. Rikshandboken i barnhälsovård. Vägledning för vaccination med levande försvagade vaccin, av barn som under graviditeten eller vid amning exponerats för immunmodulerande läkemedel. Rikshandboken i barnhälsovård [www]. [updated 2022-09-26, cited 2025-12-17].

  9. Burton PJ, Waddell BJ. Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod. 1999;60(2):234-40.

  10. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936-45.

  11. Blanford AT, Murphy BE. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977;127(3):264-7.

  12. Läkemedelsverket. Dexalcex Produktresumé. Läkemedelsverket [www]. [updated 2023-04-11, cited 2025-12-17].

  13. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.

  14. Czeizel AE, Rockenbauer M. Population-based case-control study of teratogenic potential of corticosteroids. Teratology 1997;56:335-40.

  15. Tamási L, Somoskövi A, Müller V, Bártfai Z, Acs N, Puhó E et al. A population-based case-control study on the effect of bronchial asthma during pregnancy for congenital abnormalities of the offspring. J Asthma. 2006;43(1):81-6.

  16. Mercè Fernández-Balsells M, Muthusamy K, Smushkin G, Lampropulos JF, Elamin MB, Abu Elnour NO et al. Prenatal dexamethasone use for the prevention of virilization in pregnancies at risk for classical congenital adrenal hyperplasia because of 21-hydroxylase (CYP21A2) deficiency: a systematic review and meta-analyses. Clin Endocrinol (Oxf). 2010;73(4):436-44.

  17. Filippini C, Saran S, Chari B. Musculoskeletal steroid injections in pregnancy: a review. Skeletal Radiol. 2023;52(8):1465-1473.

  1. UK Teratology Information Service (UKTIS). USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY. UKTIS [www]. [updated 2023-07-01, cited 2025-12-17].
  2. Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgård BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study. BMC Med. 2023;21(1):140.
  3. Bay Bjørn AM, Ehrenstein V, Hundborg HH, Nohr EA, Sørensen HT, Nørgaard M. Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther. 2014;21(2):73-80.
  4. Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183(7):796-804.
  5. Xiao WL, Liu XY, Liu YS, Zhang DZ, Xue LF. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017;69:99-105.
  6. Reprotox. Prednisolone. Micromedex [www]. [cited 2023-02-08].
  7. Hellgren K, Secher AE, Glintborg B, Rom AL, Gudbjornsson B, Michelsen B et al. Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark. Rheumatology (Oxford). 2022;61(9):3711-3722.
  8. Rikshandboken i barnhälsovård. Vägledning för vaccination med levande försvagade vaccin, av barn som under graviditeten eller vid amning exponerats för immunmodulerande läkemedel. Rikshandboken i barnhälsovård [www]. [updated 2022-09-26, cited 2025-12-17].
  9. Burton PJ, Waddell BJ. Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod. 1999;60(2):234-40.
  10. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936-45.
  11. Blanford AT, Murphy BE. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977;127(3):264-7.
  12. Läkemedelsverket. Dexalcex Produktresumé. Läkemedelsverket [www]. [updated 2023-04-11, cited 2025-12-17].
  13. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.
  14. Czeizel AE, Rockenbauer M. Population-based case-control study of teratogenic potential of corticosteroids. Teratology 1997;56:335-40.
  15. Tamási L, Somoskövi A, Müller V, Bártfai Z, Acs N, Puhó E et al. A population-based case-control study on the effect of bronchial asthma during pregnancy for congenital abnormalities of the offspring. J Asthma. 2006;43(1):81-6.
  16. Mercè Fernández-Balsells M, Muthusamy K, Smushkin G, Lampropulos JF, Elamin MB, Abu Elnour NO et al. Prenatal dexamethasone use for the prevention of virilization in pregnancies at risk for classical congenital adrenal hyperplasia because of 21-hydroxylase (CYP21A2) deficiency: a systematic review and meta-analyses. Clin Endocrinol (Oxf). 2010;73(4):436-44.
  17. Filippini C, Saran S, Chari B. Musculoskeletal steroid injections in pregnancy: a review. Skeletal Radiol. 2023;52(8):1465-1473.