5/29/2026

Janusmed fosterpåverkan

Janusmed fosterpåverkan – budesonid

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

För att komma till startsidan för Janusmed fosterpåverkan och för att göra sökningar klicka här.

Tillbaka till index
2 2
2 2

Budesonid – för lokal behandling i tarm och matstrupe

Budesonid – för lokal behandling i tarm och matstrupe

Klass : 2

Visa all info

Skriv ut

Kontakta oss

  1. UK Teratology Information Service (UKTIS). USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY. UKTIS [www]. [updated 2023-07-01, cited 2025-12-17].

  2. Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgård BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study. BMC Med. 2023;21(1):140.

  3. Bay Bjørn AM, Ehrenstein V, Hundborg HH, Nohr EA, Sørensen HT, Nørgaard M. Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther. 2014;21(2):73-80.

  4. Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183(7):796-804.

  5. Xiao WL, Liu XY, Liu YS, Zhang DZ, Xue LF. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017;69:99-105.

  6. Reprotox. Prednisolone. Micromedex [www]. [cited 2023-02-08].

  7. Hellgren K, Secher AE, Glintborg B, Rom AL, Gudbjornsson B, Michelsen B et al. Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark. Rheumatology (Oxford). 2022;61(9):3711-3722.

  8. Rikshandboken i barnhälsovård. Vägledning för vaccination med levande försvagade vaccin, av barn som under graviditeten eller vid amning exponerats för immunmodulerande läkemedel. Rikshandboken i barnhälsovård [www]. [updated 2022-09-26, cited 2025-12-17].

  9. Burton PJ, Waddell BJ. Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod. 1999;60(2):234-40.

  10. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936-45.

  11. Blanford AT, Murphy BE. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977;127(3):264-7.

  12. Edsbäcker S, Andersson T. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease. Clin Pharmacokinet. 2004;43(12):803-21.

  13. Dahlstrom K, Edsbacker S, Kallen A. Rectal pharmacokinetics of budesonide. Eur J Clin Pharmacol. 1996;49(4):293-8.

  14. Läkemedelsverket. Entocort (depotkapsel) Produktresumé. Läkemedelsverket [www]. [updated 2024-02-14, cited 2025-12-17].

  15. EMA. Jorveza Produktresumé. EMA [www]. [updated 2022-12-06, cited 2025-12-17].

  16. Beaulieu DB, Ananthakrishnan AN, Issa M, Rosenbaum L, Skaros S, Newcomer JR et al. Budesonide induction and maintenance therapy for Crohn's disease during pregnancy. Inflamm Bowel Dis. 2009;15(1):25-8.

  1. UK Teratology Information Service (UKTIS). USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY. UKTIS [www]. [updated 2023-07-01, cited 2025-12-17].
  2. Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgård BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study. BMC Med. 2023;21(1):140.
  3. Bay Bjørn AM, Ehrenstein V, Hundborg HH, Nohr EA, Sørensen HT, Nørgaard M. Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther. 2014;21(2):73-80.
  4. Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183(7):796-804.
  5. Xiao WL, Liu XY, Liu YS, Zhang DZ, Xue LF. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017;69:99-105.
  6. Reprotox. Prednisolone. Micromedex [www]. [cited 2023-02-08].
  7. Hellgren K, Secher AE, Glintborg B, Rom AL, Gudbjornsson B, Michelsen B et al. Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark. Rheumatology (Oxford). 2022;61(9):3711-3722.
  8. Rikshandboken i barnhälsovård. Vägledning för vaccination med levande försvagade vaccin, av barn som under graviditeten eller vid amning exponerats för immunmodulerande läkemedel. Rikshandboken i barnhälsovård [www]. [updated 2022-09-26, cited 2025-12-17].
  9. Burton PJ, Waddell BJ. Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod. 1999;60(2):234-40.
  10. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936-45.
  11. Blanford AT, Murphy BE. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977;127(3):264-7.
  12. Edsbäcker S, Andersson T. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease. Clin Pharmacokinet. 2004;43(12):803-21.
  13. Dahlstrom K, Edsbacker S, Kallen A. Rectal pharmacokinetics of budesonide. Eur J Clin Pharmacol. 1996;49(4):293-8.
  14. Läkemedelsverket. Entocort (depotkapsel) Produktresumé. Läkemedelsverket [www]. [updated 2024-02-14, cited 2025-12-17].
  15. EMA. Jorveza Produktresumé. EMA [www]. [updated 2022-12-06, cited 2025-12-17].
  16. Beaulieu DB, Ananthakrishnan AN, Issa M, Rosenbaum L, Skaros S, Newcomer JR et al. Budesonide induction and maintenance therapy for Crohn's disease during pregnancy. Inflamm Bowel Dis. 2009;15(1):25-8.
1 1
1 1

Budesonid – för inhalation

Budesonid – för inhalation

Klass : 1

Visa all info

Skriv ut

Kontakta oss

  1. Xu Z, Doust JA, Wilson LF, Dobson AJ, Dharmage SC, Mishra GD. Asthma severity and impact on perinatal outcomes: an updated systematic review and meta-analysis. BJOG. 2022;129(3):367-377.

  2. Abdullah K, Zhu J, Gershon A, Dell S, To T. Effect of asthma exacerbation during pregnancy in women with asthma: a population-based cohort study. Eur Respir J. 2020;55(2):1901335.

  3. Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J et al. A meta-analysis of adverse perinatal outcomes in women with asthma. BJOG. 2011;118(11):1314-23.

  4. Robijn AL, Harvey SM, Jensen ME, Atkins S, Quek KJD, Wang G et al. Adverse neonatal outcomes in pregnant women with asthma: An updated systematic review and meta-analysis. Int J Gynaecol Obstet. 2024;166(2):596-606.

  5. Rejnö G, Lundholm C, Gong T, Larsson K, Saltvedt S, Almqvist C. Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes. PLoS One. 2014;9(8):e104755.

  6. Murphy VE, Wang G, Namazy JA, Powell H, Gibson PG, Chambers C et al. The risk of congenital malformations, perinatal mortality and neonatal hospitalisation among pregnant women with asthma: a systematic review and meta-analysis. BJOG. 2013;120(7):812-22.

  7. Heryak SM, Oleksiak OI. The Features of Chronic Obstructive Pulmonary Disease Influence on the Pregnancy Complications Development. World Science. 2022;77(5):1-7. DOI: https://doi.org/10.31435/rsglobal_ws/30092022/7869

  8. Gen M. Antenatal care for pregnant women with Chronic Obstructive Pulmonary Disease (COPD). Int J Respir Med. 2023;8(3):147.

  9. Kallen B, Rydhstroem H, Aberg A. Asthma during pregnancy - a population based study. Eur J Epidemiol 2000;16:167-71.

  10. Liu S, Wen SW, Demissie K, Marcoux S, Kramer MS. Maternal asthma and pregnancy outcomes: A retrospective cohort study. Am J Obstet Gynecol 2001;184:90-6.

  11. Garne E, Vinkel Hansen A, Morris J, Jordan S, Klungsøyr K, Engeland A et al. Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study. BJOG. 2016;123(10):1609-18.

  12. Källén B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 3: Congenital malformations in the infants. Eur J Clin Pharmacol 2007;63:383-8.

  13. Jiao XF, Leal LF, Ducharme FM, Tse SM, Bérard A. First-trimester asthma controller medication use and major congenital malformation risk in offspring of women with asthma: A nationwide population-based cohort study. J Allergy Clin Immunol. 2026;Mar 31:S0091-6749(26)00218-6.

  14. Läkemedelsverket. Astma hos barn och vuxna – behandlings­rekommendation. Läkemedelsverket [www]. [updated 2023-03-27, cited 2026-04-20].

  15. NICE. Nice Guidelines Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN) . National Institute for Health and Care Excellence (NICE) [www]. [updated 2024-11-27, cited 2026-04-20].

  16. Garne E, Hansen AV, Morris J, Zaupper L, Addor MC, Barisic I et al. Use of asthma medication during pregnancy and risk of specific congenital anomalies: A European case-malformed control study. J Allergy Clin Immunol. 2015;136:1496-1502e7.

  17. Lim A, Stewart K, König K, George J. Systematic review of the safety of regular preventive asthma medications during pregnancy. Ann Pharmacother. 2011;45:931-45.

  18. Rahimi R, Nikfar S, Abdollahi M. Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol 2006;25:447-52.

  19. Kallen B, Rydhstroem H, Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol 1999;93:392-5.

  20. Silverman M, Sheffer A, Diaz PV, Lindmark B, Radner F, Broddene M et al. START Investigators Group. Outcome of pregnancy in a randomized controlled study of patients with asthma exposed to budesonide. Ann Allergy Asthma Immunol 2005;95:566-70.

  21. Reprotox. Budesonide. Micromedex [www]. [cited 2026-04-28].

  1. Xu Z, Doust JA, Wilson LF, Dobson AJ, Dharmage SC, Mishra GD. Asthma severity and impact on perinatal outcomes: an updated systematic review and meta-analysis. BJOG. 2022;129(3):367-377.
  2. Abdullah K, Zhu J, Gershon A, Dell S, To T. Effect of asthma exacerbation during pregnancy in women with asthma: a population-based cohort study. Eur Respir J. 2020;55(2):1901335.
  3. Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J et al. A meta-analysis of adverse perinatal outcomes in women with asthma. BJOG. 2011;118(11):1314-23.
  4. Robijn AL, Harvey SM, Jensen ME, Atkins S, Quek KJD, Wang G et al. Adverse neonatal outcomes in pregnant women with asthma: An updated systematic review and meta-analysis. Int J Gynaecol Obstet. 2024;166(2):596-606.
  5. Rejnö G, Lundholm C, Gong T, Larsson K, Saltvedt S, Almqvist C. Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes. PLoS One. 2014;9(8):e104755.
  6. Murphy VE, Wang G, Namazy JA, Powell H, Gibson PG, Chambers C et al. The risk of congenital malformations, perinatal mortality and neonatal hospitalisation among pregnant women with asthma: a systematic review and meta-analysis. BJOG. 2013;120(7):812-22.
  7. Heryak SM, Oleksiak OI. The Features of Chronic Obstructive Pulmonary Disease Influence on the Pregnancy Complications Development. World Science. 2022;77(5):1-7. DOI: https://doi.org/10.31435/rsglobal_ws/30092022/7869
  8. Gen M. Antenatal care for pregnant women with Chronic Obstructive Pulmonary Disease (COPD). Int J Respir Med. 2023;8(3):147.
  9. Kallen B, Rydhstroem H, Aberg A. Asthma during pregnancy - a population based study. Eur J Epidemiol 2000;16:167-71.
  10. Liu S, Wen SW, Demissie K, Marcoux S, Kramer MS. Maternal asthma and pregnancy outcomes: A retrospective cohort study. Am J Obstet Gynecol 2001;184:90-6.
  11. Garne E, Vinkel Hansen A, Morris J, Jordan S, Klungsøyr K, Engeland A et al. Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study. BJOG. 2016;123(10):1609-18.
  12. Källén B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 3: Congenital malformations in the infants. Eur J Clin Pharmacol 2007;63:383-8.
  13. Jiao XF, Leal LF, Ducharme FM, Tse SM, Bérard A. First-trimester asthma controller medication use and major congenital malformation risk in offspring of women with asthma: A nationwide population-based cohort study. J Allergy Clin Immunol. 2026;Mar 31:S0091-6749(26)00218-6.
  14. Läkemedelsverket. Astma hos barn och vuxna – behandlings­rekommendation. Läkemedelsverket [www]. [updated 2023-03-27, cited 2026-04-20].
  15. NICE. Nice Guidelines Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN) . National Institute for Health and Care Excellence (NICE) [www]. [updated 2024-11-27, cited 2026-04-20].
  16. Garne E, Hansen AV, Morris J, Zaupper L, Addor MC, Barisic I et al. Use of asthma medication during pregnancy and risk of specific congenital anomalies: A European case-malformed control study. J Allergy Clin Immunol. 2015;136:1496-1502e7.
  17. Lim A, Stewart K, König K, George J. Systematic review of the safety of regular preventive asthma medications during pregnancy. Ann Pharmacother. 2011;45:931-45.
  18. Rahimi R, Nikfar S, Abdollahi M. Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol 2006;25:447-52.
  19. Kallen B, Rydhstroem H, Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol 1999;93:392-5.
  20. Silverman M, Sheffer A, Diaz PV, Lindmark B, Radner F, Broddene M et al. START Investigators Group. Outcome of pregnancy in a randomized controlled study of patients with asthma exposed to budesonide. Ann Allergy Asthma Immunol 2005;95:566-70.
  21. Reprotox. Budesonide. Micromedex [www]. [cited 2026-04-28].
1 1
1 1

Budesonid – intranasalt

Budesonid – intranasalt

Klass : 1

Visa all info

Skriv ut

Kontakta oss