Aripiprazol
Aripiprazol
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ABILIFY MAINTENA, Abilify, Abilify Maintena, Abilify Maintena Kit, Ari......
ABILIFY MAINTENA, Abilify, Abilify Maintena, Abilify Maintena Kit, Aripiprazol Ebb, Aripiprazol Krka, Aripiprazol STADA, Aripiprazole Accord, Aripiprazole Accord Healthcare, Aripiprazole Aristo, Aripiprazole Medical Valley, Aripiprazole Sandoz, Aripiprazole Teva, Aripiprazole ZentivaATC-koder
N05AX12
N05AX12Substanser
aripiprazol, aripiprazolmonohydrat
aripiprazol, aripiprazolmonohydratBedömning
Behandling med aripiprazol, som tillhör gruppen atypiska neuroleptika, bör ske i samråd med specialist. Exponering för atypiska neuroleptika i tidig graviditet tycks inte generellt öka risken för missbildningar, men barn födda av kvinnor som använt neuroleptika i sen graviditet har en något ökad förekomst av neonatala symptom som andningsproblem och tecken på neurologisk påverkan. Symptomen tycks försvinna relativt snabbt, men det kan finnas behov för observation och behandling på neonatalavdelning. Barnläkare ska vara informerad om medicineringen, i samband med undersökning av den nyfödda.
Behandling med aripiprazol, som tillhör gruppen atypiska neuroleptika, bör ske i samråd med specialist. Exponering för atypiska neuroleptika i tidig graviditet tycks inte generellt öka risken för missbildningar, men barn födda av kvinnor som använt neuroleptika i sen graviditet har en något ökad förekomst av neonatala symptom som andningsproblem och tecken på neurologisk påverkan. Symptomen tycks försvinna relativt snabbt, men det kan finnas behov för observation och behandling på neonatalavdelning. Barnläkare ska vara informerad om medicineringen, i samband med undersökning av den nyfödda.Bakgrund
Gemensamt för atypiska neuroleptika
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Atypiska neuroleptika (andra generationens neuroleptika) används förutom vid psykossjukdomar även vid bipolär sjukdom. Det börjar nu finnas en del erfarenhet av behandling under graviditet, även om det varierar mellan olika substanser. Exponering för atypiska neuroleptika förefaller inte generellt vara relaterat till ökad risk för missbildningar [1-7]. Enstaka studier har visat något förhöjd risk för vissa specifika missbildningar vid användning av atypiska......
Referenser
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Ennis ZN, Damkier P. Pregnancy exposure to olanzapine, quetiapine, risperidone, aripiprazole and risk of congenital malformations A systematic review. Basic Clin Pharmacol Toxicol. 2015;116(4):315-20.
Vigod SN, Gomes T, Wilton AS, Taylor VH, Ray JG. Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study. BMJ. 2015;350:h2298.
Damkier P, Videbech P. The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review. CNS Drugs. 2018;32(4):351-366.
McKenna K, Koren G, Tetelbaum M, Wilton L, Shakir S, Diav-Citrin O et al. Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study. J Clin Psychiatry. 2005;66:444-9; quiz 546.
Yakuwa N, Takahashi K, Anzai T, Ito N, Goto M, Koinuma S et al. Pregnancy Outcomes With Exposure to Second-Generation Antipsychotics During the First Trimester. J Clin Psychiatry. 2022;83(4):21m14081.
Heinonen E, Forsberg L, Nörby U, Wide K, Källén K. Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register-Based Cohort Study in Sweden. CNS Drugs. 2022;36(5):529-539.
Huybrechts KF, Straub L, Karlsson P, Pazzagli L, Furu K, Gissler M et al. Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US. JAMA Psychiatry. 2023;80(2):156-166.
Ellfolk M, Leinonen MK, Gissler M, Kiuru-Kuhlefelt S, Saastamoinen L, Malm H. Second-generation antipsychotic use during pregnancy and risk of congenital malformations. Eur J Clin Pharmacol. 2021;77(11):1737-1745.
Kulkarni J, Worsley R, Gilbert H, Gavrilidis E, Van Rheenen TE, Wang W et al. A prospective cohort study of antipsychotic medications in pregnancy: the first 147 pregnancies and 100 one year old babies. PLoS One. 2014;9(5):e94788.
Bellet F, Beyens MN, Bernard N, Beghin D, Elefant E, Vial T. Exposure to aripiprazole during embryogenesis: a prospective multicenter cohort study. Pharmacoepidemiol Drug Saf. 2015;24:368-80.
Sadowski A, Todorow M, Yazdani Brojeni P, Koren G, Nulman I. Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study. BMJ Open. 2013;3(7):0.
Newham JJ, Thomas SH, MacRitchie K, McElhatton PR, McAllister-Williams RH. Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study. Br J Psychiatry. 2008;192(5):333-7.
Sacker A, Done DJ, Crow TJ. Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies. Psychol Med. 1996;26(2):279-87.
Rummel-Kluge C, Komossa K, Schwarz S, Hunger H, Schmid F, Lobos CA et al. Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2010;123(0):225-33.
Ellfolk M, Leinonen MK, Gissler M, Lahesmaa-Korpinen AM, Saastamoinen L, Nurminen ML et al. Second-generation antipsychotics and pregnancy complications. Eur J Clin Pharmacol. 2020;76(1):107-115.
Källén B, Borg N, Reis M. The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel). 2013;6:1221-86.
Bodén R, Lundgren M, Brandt L, Reutfors J, Kieler H. Antipsychotics during pregnancy: relation to fetal and maternal metabolic effects. Arch Gen Psychiatry. 2012;69:715-21.
Park Y, Hernandez-Diaz S, Bateman BT, Cohen JM, Desai RJ, Patorno E et al. Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes. Am J Psychiatry. 2018;175(6):564-574.
Lin HY, Lin FJ, Katz AJ, Wang IT, Wu CH. Antipsychotic Use in Early Pregnancy and the Risk of Maternal and Neonatal Complications. Mayo Clin Proc. 2022;97(11):2086-2096.
Gentile S. Antipsychotic therapy during early and late pregnancy A systematic review. Schizophr Bull. 2010;36:518-44.
Heinonen E, Forsberg L, Nörby U, Wide K, Källén K. Neonatal morbidity after fetal exposure to antipsychotics: a national register-based study. BMJ Open. 2022;12(6):e061328.
Divac N, Prostran M, Jakovcevski I, Cerovac N. Second-generation antipsychotics and extrapyramidal adverse effects. Biomed Res Int. 2014;2014(0):656370.
US Food & Drug Administration (FDA). Antipsychotic drug labels updated on use during pregnancy and risk of abnormal muscle movements and withdrawal symptoms in newborns 2011. FDA [www]. [cited 2019-01-16].
Newport DJ, Calamaras MR, DeVane CL, Donovan J, Beach AJ, Winn S et al. Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psychiatry. 2007;164(8):1214-20.
Coppola D, Russo LJ, Kwarta RF, Varughese R, Schmider J. Evaluating the postmarketing experience of risperidone use during pregnancy: pregnancy and neonatal outcomes. Drug Saf. 2007;30(3):247-64.
Wang Z, Chan AYL, Coghill D, Ip P, Lau WCY, Simonoff E et al. Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age. JAMA Intern Med. 2021;181(10):1332-1340.
Hálfdánarson Ó, Cohen JM, Karlstad Ø, Cesta CE, Bjørk MH, Håberg SE et al. Antipsychotic use in pregnancy and risk of attention/deficit-hyperactivity disorder and autism spectrum disorder: a Nordic cohort study. Evid Based Ment Health. 2022;25(2):54-62.
Straub L, Hernández-Díaz S, Bateman BT, Wisner KL, Gray KJ, Pennell PB et al. Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study. JAMA Intern Med. 2022;182(5):522-533.
Gentile S, Fusco ML. Neurodevelopmental outcomes in infants exposed in utero to antipsychotics: a systematic review of published data. CNS Spectr. 2017;22(3):273-281.
Park Y, Huybrechts KF, Cohen JM, Bateman BT, Desai RJ, Patorno E et al. Antipsychotic Medication Use Among Publicly Insured Pregnant Women in the United States. Psychiatr Serv. 2017;68(11):1112-1119.
Galbally M, Frayne J, Watson SJ, Snellen M. Aripiprazole and pregnancy: A retrospective, multicentre study. J Affect Disord. 2018;238(0):593-596.
- Ennis ZN, Damkier P. Pregnancy exposure to olanzapine, quetiapine, risperidone, aripiprazole and risk of congenital malformations A systematic review. Basic Clin Pharmacol Toxicol. 2015;116(4):315-20.
- Vigod SN, Gomes T, Wilton AS, Taylor VH, Ray JG. Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study. BMJ. 2015;350:h2298.
- Damkier P, Videbech P. The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review. CNS Drugs. 2018;32(4):351-366.
- McKenna K, Koren G, Tetelbaum M, Wilton L, Shakir S, Diav-Citrin O et al. Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study. J Clin Psychiatry. 2005;66:444-9; quiz 546.
- Yakuwa N, Takahashi K, Anzai T, Ito N, Goto M, Koinuma S et al. Pregnancy Outcomes With Exposure to Second-Generation Antipsychotics During the First Trimester. J Clin Psychiatry. 2022;83(4):21m14081.
- Heinonen E, Forsberg L, Nörby U, Wide K, Källén K. Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register-Based Cohort Study in Sweden. CNS Drugs. 2022;36(5):529-539.
- Huybrechts KF, Straub L, Karlsson P, Pazzagli L, Furu K, Gissler M et al. Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US. JAMA Psychiatry. 2023;80(2):156-166.
- Ellfolk M, Leinonen MK, Gissler M, Kiuru-Kuhlefelt S, Saastamoinen L, Malm H. Second-generation antipsychotic use during pregnancy and risk of congenital malformations. Eur J Clin Pharmacol. 2021;77(11):1737-1745.
- Kulkarni J, Worsley R, Gilbert H, Gavrilidis E, Van Rheenen TE, Wang W et al. A prospective cohort study of antipsychotic medications in pregnancy: the first 147 pregnancies and 100 one year old babies. PLoS One. 2014;9(5):e94788.
- Bellet F, Beyens MN, Bernard N, Beghin D, Elefant E, Vial T. Exposure to aripiprazole during embryogenesis: a prospective multicenter cohort study. Pharmacoepidemiol Drug Saf. 2015;24:368-80.
- Sadowski A, Todorow M, Yazdani Brojeni P, Koren G, Nulman I. Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study. BMJ Open. 2013;3(7):0.
- Newham JJ, Thomas SH, MacRitchie K, McElhatton PR, McAllister-Williams RH. Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study. Br J Psychiatry. 2008;192(5):333-7.
- Sacker A, Done DJ, Crow TJ. Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies. Psychol Med. 1996;26(2):279-87.
- Rummel-Kluge C, Komossa K, Schwarz S, Hunger H, Schmid F, Lobos CA et al. Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2010;123(0):225-33.
- Ellfolk M, Leinonen MK, Gissler M, Lahesmaa-Korpinen AM, Saastamoinen L, Nurminen ML et al. Second-generation antipsychotics and pregnancy complications. Eur J Clin Pharmacol. 2020;76(1):107-115.
- Källén B, Borg N, Reis M. The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel). 2013;6:1221-86.
- Bodén R, Lundgren M, Brandt L, Reutfors J, Kieler H. Antipsychotics during pregnancy: relation to fetal and maternal metabolic effects. Arch Gen Psychiatry. 2012;69:715-21.
- Park Y, Hernandez-Diaz S, Bateman BT, Cohen JM, Desai RJ, Patorno E et al. Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes. Am J Psychiatry. 2018;175(6):564-574.
- Lin HY, Lin FJ, Katz AJ, Wang IT, Wu CH. Antipsychotic Use in Early Pregnancy and the Risk of Maternal and Neonatal Complications. Mayo Clin Proc. 2022;97(11):2086-2096.
- Gentile S. Antipsychotic therapy during early and late pregnancy A systematic review. Schizophr Bull. 2010;36:518-44.
- Heinonen E, Forsberg L, Nörby U, Wide K, Källén K. Neonatal morbidity after fetal exposure to antipsychotics: a national register-based study. BMJ Open. 2022;12(6):e061328.
- Divac N, Prostran M, Jakovcevski I, Cerovac N. Second-generation antipsychotics and extrapyramidal adverse effects. Biomed Res Int. 2014;2014(0):656370.
- US Food & Drug Administration (FDA). Antipsychotic drug labels updated on use during pregnancy and risk of abnormal muscle movements and withdrawal symptoms in newborns 2011. FDA [www]. [cited 2019-01-16].
- Newport DJ, Calamaras MR, DeVane CL, Donovan J, Beach AJ, Winn S et al. Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psychiatry. 2007;164(8):1214-20.
- Coppola D, Russo LJ, Kwarta RF, Varughese R, Schmider J. Evaluating the postmarketing experience of risperidone use during pregnancy: pregnancy and neonatal outcomes. Drug Saf. 2007;30(3):247-64.
- Wang Z, Chan AYL, Coghill D, Ip P, Lau WCY, Simonoff E et al. Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age. JAMA Intern Med. 2021;181(10):1332-1340.
- Hálfdánarson Ó, Cohen JM, Karlstad Ø, Cesta CE, Bjørk MH, Håberg SE et al. Antipsychotic use in pregnancy and risk of attention/deficit-hyperactivity disorder and autism spectrum disorder: a Nordic cohort study. Evid Based Ment Health. 2022;25(2):54-62.
- Straub L, Hernández-Díaz S, Bateman BT, Wisner KL, Gray KJ, Pennell PB et al. Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study. JAMA Intern Med. 2022;182(5):522-533.
- Gentile S, Fusco ML. Neurodevelopmental outcomes in infants exposed in utero to antipsychotics: a systematic review of published data. CNS Spectr. 2017;22(3):273-281.
- Park Y, Huybrechts KF, Cohen JM, Bateman BT, Desai RJ, Patorno E et al. Antipsychotic Medication Use Among Publicly Insured Pregnant Women in the United States. Psychiatr Serv. 2017;68(11):1112-1119.
- Galbally M, Frayne J, Watson SJ, Snellen M. Aripiprazole and pregnancy: A retrospective, multicentre study. J Affect Disord. 2018;238(0):593-596.
Författare
Lisa Forsberg, Essi Whaites Heinonen och Karin Källén för Region Stockholm.
Lisa Forsberg, Essi Whaites Heinonen och Karin Källén för Region Stockholm.Uppdaterat
Innehållet uppdaterat 5/17/2024
Uppgifterna från födelseregistret är hämtade 4/1/2018
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