10/14/2025

Janusmed fosterpåverkan

Janusmed fosterpåverkan – 5'-kappat mRNA, kodande för fullängds-omikronvariant LP.8.1 av SARS-CoV-2 spike-protein

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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Vaccin mot covid-19 (mRNA)

Vaccin mot covid-19 (mRNA)

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  1. Pollard AJ, Bijker EM. A guide to vaccinology: from basic principles to new developments. Nat Rev Immunol. 2020;0(0):1-18.

  2. BioNTech Manufacturing GmbH. Comirnaty Produktresumé. EMA [www]. [updated 2025-09-10, cited 2025-10-10].

  3. Lauritsen CJ, Trinh IV, Desai SP, Clancey E, Murrell AE, Rambaran S et al. Passive antibody transfer from pregnant women to their fetus are maximized after SARS-CoV-2 vaccination irrespective of prior infection. J Allergy Clin Immunol Glob. 2024;3(1):100189.

  4. Prabhu M, Murphy EA, Sukhu AC, Yee J, Singh S, Eng D et al. Antibody Response to Coronavirus Disease 2019 (COVID-19) Messenger RNA Vaccination in Pregnant Women and Transplacental Passage Into Cord Blood. Obstet Gynecol. 2021;138(2):278-280.

  5. Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B et al. Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy. Nat Commun. 2022;13(1):4422.

  6. Magnus MC, Örtqvist AK, Dahlqwist E, Ljung R, Skår F, Oakley L et al. Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes. JAMA. 2022. Online first.

  7. Norman M, Magnus MC, Söderling J, Juliusson PB, Navér L, Örtqvist AK et al. Neonatal Outcomes After COVID-19 Vaccination in Pregnancy. JAMA. 2024;331(5):396-407.

  8. Shimabukuro TT, Kim SY, Myers TR, Moro PL, Oduyebo T, Panagiotakopoulos L et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. N Engl J Med. 2021.

  9. Zauche LH, Wallace B, Smoots AN, Olson CK, Oduyebo T, Kim SY et al. Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion. N Engl J Med. 2021;385(16):1533-1535.

  10. Magnus MC, Gjessing HK, Eide HN, Wilcox AJ, Fell DB, Håberg SE. Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage. N Engl J Med. 2021;0(0):0.

  11. Blakeway H, Prasad S, Kalafat E2, Heath PT, Ladhani SN, Doare KL, Magee LA, O'Brien P, Rezvani A, von Dadelszen P, Khalil A . COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstet Gynecol . 2021 Aug 10;0(0):0.

  12. Goldshtein I, Steinberg DM, Kuint J, Chodick G, Segal Y, Shapiro Ben David S et al. Association of BNT162b2 COVID-19 Vaccination During Pregnancy With Neonatal and Early Infant Outcomes. JAMA Pediatr. 2022 Feb 10;e220001. doi: 10.1001/jamapediatrics.2022.0001. Online ahead of print.

  13. Fell DB, Dhinsa T, Alton GD, Török E, Dimanlig-Cruz S, Regan AK et al. Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes. JAMA. 2022. Online first

  14. Prasad S, Kalafat E, Blakeway H, Townsend R, O'Brien P, Morris E et al. Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy. Nat Commun. 2022;13(1):2414.

  15. Barros FC, Gunier RB, Rego A, Sentilhes L, Rauch S, Gandino S et al. Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study. Am J Obstet Gynecol. 2024;231(4):460e1-460e17.

  16. Rowe SL, Sullivan SG, Muñoz FM, Coates MM, Agnew B, Arah OA et al. COVID-19 Vaccination During Pregnancy and Major Structural Birth Defects. Pediatrics. 2025;155 (4): e2024069778.

  17. Magnus MC, Söderling J, Örtqvist AK, Andersen AN, Stephansson O, Håberg SE et al. Covid-19 infection and vaccination during first trimester and risk of congenital anomalies: Nordic registry based study. BMJ. 2024;386:e079364.

  18. Kharbanda EO, DeSilva MB, Lipkind HS, Romitti PA, Zhu J, Vesco KK et al. COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births. JAMA Pediatr. 2024;178(8):823-829.

  19. Folkhälsomyndigheten. Rekommendationer om vaccination mot covid-19 - faktablad. Folkhälsomyndigheten [www]. [updated 2025-09-11, cited 2025-10-10].

  1. Pollard AJ, Bijker EM. A guide to vaccinology: from basic principles to new developments. Nat Rev Immunol. 2020;0(0):1-18.
  2. BioNTech Manufacturing GmbH. Comirnaty Produktresumé. EMA [www]. [updated 2025-09-10, cited 2025-10-10].
  3. Lauritsen CJ, Trinh IV, Desai SP, Clancey E, Murrell AE, Rambaran S et al. Passive antibody transfer from pregnant women to their fetus are maximized after SARS-CoV-2 vaccination irrespective of prior infection. J Allergy Clin Immunol Glob. 2024;3(1):100189.
  4. Prabhu M, Murphy EA, Sukhu AC, Yee J, Singh S, Eng D et al. Antibody Response to Coronavirus Disease 2019 (COVID-19) Messenger RNA Vaccination in Pregnant Women and Transplacental Passage Into Cord Blood. Obstet Gynecol. 2021;138(2):278-280.
  5. Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B et al. Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy. Nat Commun. 2022;13(1):4422.
  6. Magnus MC, Örtqvist AK, Dahlqwist E, Ljung R, Skår F, Oakley L et al. Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes. JAMA. 2022. Online first.
  7. Norman M, Magnus MC, Söderling J, Juliusson PB, Navér L, Örtqvist AK et al. Neonatal Outcomes After COVID-19 Vaccination in Pregnancy. JAMA. 2024;331(5):396-407.
  8. Shimabukuro TT, Kim SY, Myers TR, Moro PL, Oduyebo T, Panagiotakopoulos L et al. Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. N Engl J Med. 2021.
  9. Zauche LH, Wallace B, Smoots AN, Olson CK, Oduyebo T, Kim SY et al. Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion. N Engl J Med. 2021;385(16):1533-1535.
  10. Magnus MC, Gjessing HK, Eide HN, Wilcox AJ, Fell DB, Håberg SE. Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage. N Engl J Med. 2021;0(0):0.
  11. Blakeway H, Prasad S, Kalafat E2, Heath PT, Ladhani SN, Doare KL, Magee LA, O'Brien P, Rezvani A, von Dadelszen P, Khalil A . COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstet Gynecol . 2021 Aug 10;0(0):0.
  12. Goldshtein I, Steinberg DM, Kuint J, Chodick G, Segal Y, Shapiro Ben David S et al. Association of BNT162b2 COVID-19 Vaccination During Pregnancy With Neonatal and Early Infant Outcomes. JAMA Pediatr. 2022 Feb 10;e220001. doi: 10.1001/jamapediatrics.2022.0001. Online ahead of print.
  13. Fell DB, Dhinsa T, Alton GD, Török E, Dimanlig-Cruz S, Regan AK et al. Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes. JAMA. 2022. Online first
  14. Prasad S, Kalafat E, Blakeway H, Townsend R, O'Brien P, Morris E et al. Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy. Nat Commun. 2022;13(1):2414.
  15. Barros FC, Gunier RB, Rego A, Sentilhes L, Rauch S, Gandino S et al. Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study. Am J Obstet Gynecol. 2024;231(4):460e1-460e17.
  16. Rowe SL, Sullivan SG, Muñoz FM, Coates MM, Agnew B, Arah OA et al. COVID-19 Vaccination During Pregnancy and Major Structural Birth Defects. Pediatrics. 2025;155 (4): e2024069778.
  17. Magnus MC, Söderling J, Örtqvist AK, Andersen AN, Stephansson O, Håberg SE et al. Covid-19 infection and vaccination during first trimester and risk of congenital anomalies: Nordic registry based study. BMJ. 2024;386:e079364.
  18. Kharbanda EO, DeSilva MB, Lipkind HS, Romitti PA, Zhu J, Vesco KK et al. COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births. JAMA Pediatr. 2024;178(8):823-829.
  19. Folkhälsomyndigheten. Rekommendationer om vaccination mot covid-19 - faktablad. Folkhälsomyndigheten [www]. [updated 2025-09-11, cited 2025-10-10].