11/21/2024

Janusmed fosterpåverkan

Janusmed fosterpåverkan – Paracut

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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  1. UK Teratology Information Service (UKTIS). Therapeutic use of paracetamol in pregnancy August 2023 Version 2. UKTIS [www]. [cited 2024-05-02].

  2. Ricci, C, Albanese, CM, Pablo, LA, et al. In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2023; 00: 1- 12. doi:10.1111/ppe.12963

  3. Bornehag CG, Reichenberg A, Hallerback MU, Wikstrom S, Koch HM, Jonsson BA et al. Prenatal exposure to acetaminophen and children's language development at 30 months. Eur Psychiatry. 2017;:.

  4. Ystrom E, Gustavson K, Brandlistuen RE, Knudsen GP, Magnus P, Susser E et al. Prenatal Exposure to Acetaminophen and Risk of ADHD. Pediatrics. 2017;140:.

  5. Liew Z, Ritz B, Rebordosa C, Lee PC, Olsen J. Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. JAMA Pediatr. 2014;168:313-20.

  6. Brandlistuen RE, Ystrom E, Nulman I, Koren G, Nordeng H. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study. Int J Epidemiol. 2013;42:1702-13.

  7. Viberg H, Eriksson P, Gordh T, Fredriksson A. Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response in adult male mice. Toxicol Sci. 2014;138:139-47.

  8. Damkier P, Cleary B, Weber-Schoendorfer C, Shechtman S, Cassina M, Panchaud A et al. Handle with care - interpretation, synthesis and dissemination of data on paracetamol in pregnancy. Nat Rev Endocrinol. 2021.

  9. Damkier P. Pledging my time: In utero exposure to acetaminophen and childhood neurodevelopment. Paediatr Perinat Epidemiol. 2023. Online ahead of print. doi.org/10.1111/ppe.12985

  10. Ahlqvist VH, Sjöqvist H, Dalman C, Karlsson H, Stephansson O, Johansson S et al. Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331(14):1205-1214.

  11. Gustavson, K., Ystrom, E., Ask, H., Ask Torvik, F., Hornig, M., Susser, E., Lipkin, W.I., Lupattelli, A., Stoltenberg, C., Magnus, P., Mjaaland, S., Askeland, R.B., Walle, K.M., Bresnahan, M., Nordeng, H. and Reichborn-Kjennerud, T. (2021), Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study. JCPP Advances, 1: e12020. https://doi.org/10.1002/jcv2.12020

  12. Jensen MS, Rebordosa C, Thulstrup AM, Toft G, Sørensen HT, Bonde JP, Henriksen TB, Olsen J Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism. Epidemiology 2010;21:779-85.

  13. Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum Reprod. 2011;26(1):235-44.

  14. Snijder CA, Kortenkamp A, Steegers EA, Jaddoe VW, Hofman A, Hass U et al. Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study. Hum Reprod. 2012;27(4):1191-201.

  15. Fisher BG, Thankamony A, Hughes IA, Ong KK, Dunger DB, Acerini CL. Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants. Hum Reprod. 2016;31(11):2642-2650.

  16. Lind DV, Main KM, Kyhl HB, Kristensen DM, Toppari J, Andersen HR et al. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs. Hum Reprod. 2017;32(1):223-231.

  17. Navarro-Lafuente F, Arense-Gonzalo JJ, Adoamnei E, Prieto-Sánchez MT, Sánchez-Ferrer ML, García-Marcos L et al. Is Maternal Use of Paracetamol during Pregnancy Associated with Anogenital Distance in Male Newborns? The Results from the NELA Birth Cohort. Int J Environ Res Public Health. 2021;18(12):6338.

  18. Rebordosa C, Kogevinas M, Horváth-Puhó E, Nørgård B, Morales M, Czeizel AE et al. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. Am J Obstet Gynecol. 2008;198(2):178e1-7.

  19. Feldkamp ML, Meyer RE, Krikov S, Botto LD. Acetaminophen use in pregnancy and risk of birth defects: findings from the National Birth Defects Prevention Study. Obstet Gynecol. 2010;115(1):109-115.

  20. Lind JN, Tinker SC, Broussard CS, Reefhuis J, Carmichael SL, Honein MA et al. Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997-2007. Pharmacoepidemiol Drug Saf. 2013;22(7):783-93.

  21. Fan G, Wang B, Liu C, Li D. Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis. Allergol Immunopathol (Madr). 2017;45(6):528-533.

  22. Shaheen SO, Lundholm C, Brew BK, Almqvist C. Prescribed analgesics in pregnancy and risk of childhood asthma. Eur Respir J. 2019;53(5).

  23. Källén B, Finnström O, Nygren KG, Otterblad Olausson P. Maternal drug use during pregnancy and asthma risk among children. Pediatr Allergy Immunol. 2013;24:28-32.

  24. UK Teratology Information Service (UKTIS). Paracetamol overdose in pregnancy August, 2023 Version 14. UKTIS [www]. [cited 2024-05-02].

  25. McElhatton PR, Sullivan FM, Volans GN. Paracetamol overdose in pregnancy analysis of the outcomes of 300 cases referred to the Teratology Information Service. Reprod Toxicol. 1997;11:85-94.

  1. UK Teratology Information Service (UKTIS). Therapeutic use of paracetamol in pregnancy August 2023 Version 2. UKTIS [www]. [cited 2024-05-02].
  2. Ricci, C, Albanese, CM, Pablo, LA, et al. In utero acetaminophen exposure and child neurodevelopmental outcomes: Systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2023; 00: 1- 12. doi:10.1111/ppe.12963
  3. Bornehag CG, Reichenberg A, Hallerback MU, Wikstrom S, Koch HM, Jonsson BA et al. Prenatal exposure to acetaminophen and children's language development at 30 months. Eur Psychiatry. 2017;:.
  4. Ystrom E, Gustavson K, Brandlistuen RE, Knudsen GP, Magnus P, Susser E et al. Prenatal Exposure to Acetaminophen and Risk of ADHD. Pediatrics. 2017;140:.
  5. Liew Z, Ritz B, Rebordosa C, Lee PC, Olsen J. Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. JAMA Pediatr. 2014;168:313-20.
  6. Brandlistuen RE, Ystrom E, Nulman I, Koren G, Nordeng H. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study. Int J Epidemiol. 2013;42:1702-13.
  7. Viberg H, Eriksson P, Gordh T, Fredriksson A. Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response in adult male mice. Toxicol Sci. 2014;138:139-47.
  8. Damkier P, Cleary B, Weber-Schoendorfer C, Shechtman S, Cassina M, Panchaud A et al. Handle with care - interpretation, synthesis and dissemination of data on paracetamol in pregnancy. Nat Rev Endocrinol. 2021.
  9. Damkier P. Pledging my time: In utero exposure to acetaminophen and childhood neurodevelopment. Paediatr Perinat Epidemiol. 2023. Online ahead of print. doi.org/10.1111/ppe.12985
  10. Ahlqvist VH, Sjöqvist H, Dalman C, Karlsson H, Stephansson O, Johansson S et al. Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331(14):1205-1214.
  11. Gustavson, K., Ystrom, E., Ask, H., Ask Torvik, F., Hornig, M., Susser, E., Lipkin, W.I., Lupattelli, A., Stoltenberg, C., Magnus, P., Mjaaland, S., Askeland, R.B., Walle, K.M., Bresnahan, M., Nordeng, H. and Reichborn-Kjennerud, T. (2021), Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study. JCPP Advances, 1: e12020. https://doi.org/10.1002/jcv2.12020
  12. Jensen MS, Rebordosa C, Thulstrup AM, Toft G, Sørensen HT, Bonde JP, Henriksen TB, Olsen J Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism. Epidemiology 2010;21:779-85.
  13. Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum Reprod. 2011;26(1):235-44.
  14. Snijder CA, Kortenkamp A, Steegers EA, Jaddoe VW, Hofman A, Hass U et al. Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study. Hum Reprod. 2012;27(4):1191-201.
  15. Fisher BG, Thankamony A, Hughes IA, Ong KK, Dunger DB, Acerini CL. Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants. Hum Reprod. 2016;31(11):2642-2650.
  16. Lind DV, Main KM, Kyhl HB, Kristensen DM, Toppari J, Andersen HR et al. Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs. Hum Reprod. 2017;32(1):223-231.
  17. Navarro-Lafuente F, Arense-Gonzalo JJ, Adoamnei E, Prieto-Sánchez MT, Sánchez-Ferrer ML, García-Marcos L et al. Is Maternal Use of Paracetamol during Pregnancy Associated with Anogenital Distance in Male Newborns? The Results from the NELA Birth Cohort. Int J Environ Res Public Health. 2021;18(12):6338.
  18. Rebordosa C, Kogevinas M, Horváth-Puhó E, Nørgård B, Morales M, Czeizel AE et al. Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. Am J Obstet Gynecol. 2008;198(2):178e1-7.
  19. Feldkamp ML, Meyer RE, Krikov S, Botto LD. Acetaminophen use in pregnancy and risk of birth defects: findings from the National Birth Defects Prevention Study. Obstet Gynecol. 2010;115(1):109-115.
  20. Lind JN, Tinker SC, Broussard CS, Reefhuis J, Carmichael SL, Honein MA et al. Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997-2007. Pharmacoepidemiol Drug Saf. 2013;22(7):783-93.
  21. Fan G, Wang B, Liu C, Li D. Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis. Allergol Immunopathol (Madr). 2017;45(6):528-533.
  22. Shaheen SO, Lundholm C, Brew BK, Almqvist C. Prescribed analgesics in pregnancy and risk of childhood asthma. Eur Respir J. 2019;53(5).
  23. Källén B, Finnström O, Nygren KG, Otterblad Olausson P. Maternal drug use during pregnancy and asthma risk among children. Pediatr Allergy Immunol. 2013;24:28-32.
  24. UK Teratology Information Service (UKTIS). Paracetamol overdose in pregnancy August, 2023 Version 14. UKTIS [www]. [cited 2024-05-02].
  25. McElhatton PR, Sullivan FM, Volans GN. Paracetamol overdose in pregnancy analysis of the outcomes of 300 cases referred to the Teratology Information Service. Reprod Toxicol. 1997;11:85-94.