7/11/2025

Janusmed fosterpåverkan

Janusmed fosterpåverkan – Olmetec Plus

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

För att komma till startsidan för Janusmed fosterpåverkan och för att göra sökningar klicka här.

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3 3

Olmesartan

Olmesartan

Klass : 3

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  1. Briggs G, Freeman RK, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 11th ed; 2017.

  2. Shimada C, Akaishi R, Cho K, Morikawa M, Kaneshi Y, Yamda T et al. Outcomes of 83 fetuses exposed to angiotensin receptor blockers during the second or third trimesters: a literature review. Hypertens Res. 2015;38(5):308-13.

  3. Alwan S, Polifka JE, Friedman JM. Angiotensin II receptor antagonist treatment during pregnancy. Birth Defects Res A Clin Mol Teratol 2005;73:123-30.

  4. Barr M. Teratogen update: angiotensin-converting enzyme inhibitors. Teratology 1994;50:399-409.

  5. Weber-Schoendorfer C, Kayser A, Tissen-Diabaté T, Winterfeld U, Eleftheriou G, Te Winkel B et al. Fetotoxic risk of AT1 blockers exceeds that of angiotensin-converting enzyme inhibitors: an observational study. J Hypertens. 2020;38(1):133-141.

  6. Lennestål R, Otterblad Olausson P, Källén B. Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants. Eur J Clin Pharmacol 2009;65:615-25.

  7. Fu J, Tomlinson G, Feig DS. Increased risk of major congenital malformations in early pregnancy use of angiotensin-converting-enzyme inhibitors and angiotensin-receptor-blockers: a meta-analysis. Diabetes Metab Res Rev. 2021;37(8):e3453.

  8. Celentano C, Prefumo F, di Vera E, Iannicco A, Gallo DP, Liberati M. Reversible acute fetal renal failure due to maternal exposure to angiotensin receptor blocker. Pediatr Nephrol. 2008;23(2):333-4.

  9. Georgaki-Angelaki E, Stergiou N, Naoum E, Papassotiriou I, Anagnostakou M. Olmesartan medoxomil-induced acute renal failure in a premature newborn following maternal exposure during pregnancy: a case report and review of the literature. NDT Plus. 2009;2(4):295-7.

  10. Hünseler C, Paneitz A, Friedrich D, Lindner U, Oberthuer A, Körber F et al. Angiotensin II receptor blocker induced fetopathy: 7 cases. Klin Padiatr. 2011;223(1):10-4.

  11. Spaggiari E, Heidet L, Grange G, Guimiot F, Dreux S, Delezoide AL et al. Prognosis and outcome of pregnancies exposed to renin-angiotensin system blockers. Prenat Diagn. 2012;32(11):1071-6.

  12. Gang MH, Lee YW, Chang MY. Secondary renal tubular dysgenesis in a newborn exposed to angiotensin Ⅱ receptor antagonist during gestation. Clin Exp Pediatr. 2021;64(3):136-138.

  1. Briggs G, Freeman RK, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 11th ed; 2017.
  2. Shimada C, Akaishi R, Cho K, Morikawa M, Kaneshi Y, Yamda T et al. Outcomes of 83 fetuses exposed to angiotensin receptor blockers during the second or third trimesters: a literature review. Hypertens Res. 2015;38(5):308-13.
  3. Alwan S, Polifka JE, Friedman JM. Angiotensin II receptor antagonist treatment during pregnancy. Birth Defects Res A Clin Mol Teratol 2005;73:123-30.
  4. Barr M. Teratogen update: angiotensin-converting enzyme inhibitors. Teratology 1994;50:399-409.
  5. Weber-Schoendorfer C, Kayser A, Tissen-Diabaté T, Winterfeld U, Eleftheriou G, Te Winkel B et al. Fetotoxic risk of AT1 blockers exceeds that of angiotensin-converting enzyme inhibitors: an observational study. J Hypertens. 2020;38(1):133-141.
  6. Lennestål R, Otterblad Olausson P, Källén B. Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants. Eur J Clin Pharmacol 2009;65:615-25.
  7. Fu J, Tomlinson G, Feig DS. Increased risk of major congenital malformations in early pregnancy use of angiotensin-converting-enzyme inhibitors and angiotensin-receptor-blockers: a meta-analysis. Diabetes Metab Res Rev. 2021;37(8):e3453.
  8. Celentano C, Prefumo F, di Vera E, Iannicco A, Gallo DP, Liberati M. Reversible acute fetal renal failure due to maternal exposure to angiotensin receptor blocker. Pediatr Nephrol. 2008;23(2):333-4.
  9. Georgaki-Angelaki E, Stergiou N, Naoum E, Papassotiriou I, Anagnostakou M. Olmesartan medoxomil-induced acute renal failure in a premature newborn following maternal exposure during pregnancy: a case report and review of the literature. NDT Plus. 2009;2(4):295-7.
  10. Hünseler C, Paneitz A, Friedrich D, Lindner U, Oberthuer A, Körber F et al. Angiotensin II receptor blocker induced fetopathy: 7 cases. Klin Padiatr. 2011;223(1):10-4.
  11. Spaggiari E, Heidet L, Grange G, Guimiot F, Dreux S, Delezoide AL et al. Prognosis and outcome of pregnancies exposed to renin-angiotensin system blockers. Prenat Diagn. 2012;32(11):1071-6.
  12. Gang MH, Lee YW, Chang MY. Secondary renal tubular dysgenesis in a newborn exposed to angiotensin Ⅱ receptor antagonist during gestation. Clin Exp Pediatr. 2021;64(3):136-138.
2 2
2 2

Hydroklortiazid

Hydroklortiazid

Klass : 2

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Kontakta oss

  1. Reprotox. Micromedex [www]. [cited 2020-04-14].

  2. Briggs G, Freeman RK, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 11th ed; 2017.

  3. Lennestål R, Otterblad Olausson P, Källén B. Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants. Eur J Clin Pharmacol 2009;65:615-25.

  4. Orbach H, Matok I, Gorodischer R, Sheiner E, Daniel S, Wiznitzer A et al. Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes. Am J Obstet Gynecol. 2013;208(4):301e1-6.

  1. Reprotox. Micromedex [www]. [cited 2020-04-14].
  2. Briggs G, Freeman RK, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 11th ed; 2017.
  3. Lennestål R, Otterblad Olausson P, Källén B. Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants. Eur J Clin Pharmacol 2009;65:615-25.
  4. Orbach H, Matok I, Gorodischer R, Sheiner E, Daniel S, Wiznitzer A et al. Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes. Am J Obstet Gynecol. 2013;208(4):301e1-6.