12/28/2025

Janusmed fosterpåverkan

Janusmed fosterpåverkan – Lodotra

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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  1. UK Teratology Information Service (UKTIS). USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY. UKTIS [www]. [updated 2023-07-01, cited 2025-12-17].

  2. Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgård BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study. BMC Med. 2023;21(1):140.

  3. Bay Bjørn AM, Ehrenstein V, Hundborg HH, Nohr EA, Sørensen HT, Nørgaard M. Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther. 2014;21(2):73-80.

  4. Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183(7):796-804.

  5. Xiao WL, Liu XY, Liu YS, Zhang DZ, Xue LF. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017;69:99-105.

  6. Reprotox. Prednisolone. Micromedex [www]. [cited 2023-02-08].

  7. Hellgren K, Secher AE, Glintborg B, Rom AL, Gudbjornsson B, Michelsen B et al. Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark. Rheumatology (Oxford). 2022;61(9):3711-3722.

  8. Rikshandboken i barnhälsovård. Vägledning för vaccination med levande försvagade vaccin, av barn som under graviditeten eller vid amning exponerats för immunmodulerande läkemedel. Rikshandboken i barnhälsovård [www]. [updated 2022-09-26, cited 2025-12-17].

  9. Burton PJ, Waddell BJ. Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod. 1999;60(2):234-40.

  10. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936-45.

  11. Blanford AT, Murphy BE. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977;127(3):264-7.

  12. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.

  13. Puckett Y, Patel P, Bokhari AA. Prednisone. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025

  14. Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hunnisett L et al. Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000;62:385-92.

  15. Reprotox. Prednisone. Micromedex [www]. [cited 2025-12-18].

  16. Gur C, Diavitrin O, Schechtman S, Arnon J, Onroy A. Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study. Reprod Toxicol 2004;18:93-101.

  1. UK Teratology Information Service (UKTIS). USE OF SYSTEMIC CORTICOSTEROIDS IN PREGNANCY. UKTIS [www]. [updated 2023-07-01, cited 2025-12-17].
  2. Jølving LR, Nielsen J, Andersen ML, Friedman S, Nørgård BM. Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study. BMC Med. 2023;21(1):140.
  3. Bay Bjørn AM, Ehrenstein V, Hundborg HH, Nohr EA, Sørensen HT, Nørgaard M. Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther. 2014;21(2):73-80.
  4. Hviid A, Mølgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183(7):796-804.
  5. Xiao WL, Liu XY, Liu YS, Zhang DZ, Xue LF. The relationship between maternal corticosteroid use and orofacial clefts-a meta-analysis. Reprod Toxicol. 2017;69:99-105.
  6. Reprotox. Prednisolone. Micromedex [www]. [cited 2023-02-08].
  7. Hellgren K, Secher AE, Glintborg B, Rom AL, Gudbjornsson B, Michelsen B et al. Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark. Rheumatology (Oxford). 2022;61(9):3711-3722.
  8. Rikshandboken i barnhälsovård. Vägledning för vaccination med levande försvagade vaccin, av barn som under graviditeten eller vid amning exponerats för immunmodulerande läkemedel. Rikshandboken i barnhälsovård [www]. [updated 2022-09-26, cited 2025-12-17].
  9. Burton PJ, Waddell BJ. Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod. 1999;60(2):234-40.
  10. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81(5):936-45.
  11. Blanford AT, Murphy BE. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol. 1977;127(3):264-7.
  12. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.
  13. Puckett Y, Patel P, Bokhari AA. Prednisone. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025
  14. Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hunnisett L et al. Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000;62:385-92.
  15. Reprotox. Prednisone. Micromedex [www]. [cited 2025-12-18].
  16. Gur C, Diavitrin O, Schechtman S, Arnon J, Onroy A. Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study. Reprod Toxicol 2004;18:93-101.