11/9/2026

Janusmed fosterpåverkan

Janusmed fosterpåverkan – Lidokain-nafazolin (ofärgad) APL

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

För att komma till startsidan för Janusmed fosterpåverkan och för att göra sökningar klicka här.

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Nafazolin

Nafazolin

Klass : 2

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  1. Laboratorios Cinfa, SA. Optialerg. Produktresumé. The Spanish Agency of Medicines and Medical Devices [www]. [updated 2025-07-01, cited 2026-10-28].

  2. Thomseth V, Cejvanovic V, Jimenez-Solem E, Poulsen HE, Utheim TP, Andersen JT. Exposure to antazoline-naphazoline eye drops during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study. Acta Ophthalmol. 2019;97(5):505-509.

  3. Reprotox. Naphazoline . Micromedex [www]. [cited 2026-10-28].

  1. Laboratorios Cinfa, SA. Optialerg. Produktresumé. The Spanish Agency of Medicines and Medical Devices [www]. [updated 2025-07-01, cited 2026-10-28].
  2. Thomseth V, Cejvanovic V, Jimenez-Solem E, Poulsen HE, Utheim TP, Andersen JT. Exposure to antazoline-naphazoline eye drops during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study. Acta Ophthalmol. 2019;97(5):505-509.
  3. Reprotox. Naphazoline . Micromedex [www]. [cited 2026-10-28].
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Lidokain

Lidokain

Klass : 2

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  1. McLure HA, Rubin AP. Review of local anaesthetic agents. Minerva Anestesiol. 2005;71(3):59-74.

  2. Becker DE, Reed KL. Essentials of local anesthetic pharmacology. Anesth Prog. 2006;53(3):98-108.

  3. Guay J. Methemoglobinemia related to local anesthetics: a summary of 242 episodes. Anesth Analg. 2009;108(3):837-45.

  4. Petrie RH. The effect of local anesthetics on fetal heart rate. Bull N Y Acad Med. 1976;52(2):226-30.

  5. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Publishing Sciences Group, Littleton, Mass. 1977.

  6. de Barros Duarte L, Dantas Móises EC, Cavalli RC, Lanchote VL, Duarte G, da Cunha SP. Distribution of bupivacaine enantiomers and lidocaine and its metabolite in the placental intervillous space and in the different maternal and fetal compartments in term pregnant women. J Clin Pharmacol. 2011;51(2):212-7.

  7. Erol S, Arslan Z, Celik IH, Bas AY, Demirel N. Transient Methemoglobinemia in three Neonates due to Maternal Pudendal Anesthesia. J Coll Physicians Surg Pak. 2017;27(12):783-784.

  1. McLure HA, Rubin AP. Review of local anaesthetic agents. Minerva Anestesiol. 2005;71(3):59-74.
  2. Becker DE, Reed KL. Essentials of local anesthetic pharmacology. Anesth Prog. 2006;53(3):98-108.
  3. Guay J. Methemoglobinemia related to local anesthetics: a summary of 242 episodes. Anesth Analg. 2009;108(3):837-45.
  4. Petrie RH. The effect of local anesthetics on fetal heart rate. Bull N Y Acad Med. 1976;52(2):226-30.
  5. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Publishing Sciences Group, Littleton, Mass. 1977.
  6. de Barros Duarte L, Dantas Móises EC, Cavalli RC, Lanchote VL, Duarte G, da Cunha SP. Distribution of bupivacaine enantiomers and lidocaine and its metabolite in the placental intervillous space and in the different maternal and fetal compartments in term pregnant women. J Clin Pharmacol. 2011;51(2):212-7.
  7. Erol S, Arslan Z, Celik IH, Bas AY, Demirel N. Transient Methemoglobinemia in three Neonates due to Maternal Pudendal Anesthesia. J Coll Physicians Surg Pak. 2017;27(12):783-784.