12/15/2025

Janusmed fosterpåverkan

Janusmed fosterpåverkan – Auvelity

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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Dextrometorfan

Dextrometorfan

Klass : 2

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  1. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.

  2. Reprotox. Dextromethorphan. Micromedex [www]. [cited 2025-10-07].

  3. Cao Y, Rhoads A, Burns T, Carnahan RM, Conway KM, Werler MM, Mitchell A, Romitti P. Maternal use of cough medications during early pregnancy and selected birth defects: a US multisite, case–control study. BMJ Open. 2021;11(12):e053604.

  1. Briggs G, Towers CV, Forinash AB. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 12th ed; 2021.
  2. Reprotox. Dextromethorphan. Micromedex [www]. [cited 2025-10-07].
  3. Cao Y, Rhoads A, Burns T, Carnahan RM, Conway KM, Werler MM, Mitchell A, Romitti P. Maternal use of cough medications during early pregnancy and selected birth defects: a US multisite, case–control study. BMJ Open. 2021;11(12):e053604.
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2 2

Bupropion

Bupropion

Klass : 2

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  1. Turner E, Jones M, Vaz LR, Coleman T. Systematic Review and Meta-Analysis to Assess the Safety of Bupropion and Varenicline in Pregnancy. Nicotine Tob Res. 2019;21(8):1001-1010.

  2. Chun-Fai-Chan B, Koren G, Fayez I, Kalra S, Voyer-Lavigne S, Boshier A et al. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 2005;192:932-936.

  3. Cole JA, Modell JG, Haight BR, Cosmatos IS, Stoler JM, Walker AM. Bupropion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf. 2007;16:474-84.

  4. Louik C, Kerr S, Mitchell AA. First-trimester exposure to bupropion and risk of cardiac malformations. Pharmacoepidemiol Drug Saf. 2014;23(10):1066-75.

  5. Alwan S, Reefhuis J, Botto LD, Rasmussen SA, Correa A, Friedman JM et al. Maternal use of bupropion and risk for congenital heart defects. Am J Obstet Gynecol. 2010;203:52e1-6.

  6. Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM et al. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med. 2014;370(25):2397-407.

  7. Tran DT, Cohen JM, Donald S, Cesta CE, Furu K, Parkin L et al. Risk of Major Congenital Malformations Following Prenatal Exposure to Smoking Cessation Medicines. JAMA Intern Med. 2025;185(6):656-667.

  8. Marks C, Silvola R, Teal E, Quinney SK, Haas DM. Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy. 2021;41(11):907-914.

  9. Tran DT, Preen DB, Einarsdottir K, Kemp-Casey A, Randall D, Jorm LR et al. Use of smoking cessation pharmacotherapies during pregnancy is not associated with increased risk of adverse pregnancy outcomes: a population-based cohort study. BMC Med. 2020;18(1):15.

  10. Claire R, Chamberlain C, Davey MA, Cooper SE, Berlin I, Leonardi-Bee J et al. Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev. 2020;3(3):CD010078.

  11. Nörby U, Forsberg L, Wide K, Sjörs G, Winbladh B, Källén K. Neonatal Morbidity After Maternal Use of Antidepressant Drugs During Pregnancy. Pediatrics. 2016;138:.

  12. Rotem-Kohavi N, Williams LJ, Virji-Babul N, Bjornson BH, Brain U, Werker JF et al. Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(1):39-49.

  13. Huybrechts KF, Bateman BT, Palmsten K, Desai RJ, Patorno E, Gopalakrishnan C et al. Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA. 2015;313(21):2142-51.

  14. Munk-Olsen T, Bergink V, Rommel AS, Momen N, Liu X. Association of Persistent Pulmonary Hypertension in Infants With the Timing and Type of Antidepressants In Utero. JAMA Netw Open. 2021;4(12):e2136639.

  1. Turner E, Jones M, Vaz LR, Coleman T. Systematic Review and Meta-Analysis to Assess the Safety of Bupropion and Varenicline in Pregnancy. Nicotine Tob Res. 2019;21(8):1001-1010.
  2. Chun-Fai-Chan B, Koren G, Fayez I, Kalra S, Voyer-Lavigne S, Boshier A et al. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 2005;192:932-936.
  3. Cole JA, Modell JG, Haight BR, Cosmatos IS, Stoler JM, Walker AM. Bupropion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf. 2007;16:474-84.
  4. Louik C, Kerr S, Mitchell AA. First-trimester exposure to bupropion and risk of cardiac malformations. Pharmacoepidemiol Drug Saf. 2014;23(10):1066-75.
  5. Alwan S, Reefhuis J, Botto LD, Rasmussen SA, Correa A, Friedman JM et al. Maternal use of bupropion and risk for congenital heart defects. Am J Obstet Gynecol. 2010;203:52e1-6.
  6. Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM et al. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med. 2014;370(25):2397-407.
  7. Tran DT, Cohen JM, Donald S, Cesta CE, Furu K, Parkin L et al. Risk of Major Congenital Malformations Following Prenatal Exposure to Smoking Cessation Medicines. JAMA Intern Med. 2025;185(6):656-667.
  8. Marks C, Silvola R, Teal E, Quinney SK, Haas DM. Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy. 2021;41(11):907-914.
  9. Tran DT, Preen DB, Einarsdottir K, Kemp-Casey A, Randall D, Jorm LR et al. Use of smoking cessation pharmacotherapies during pregnancy is not associated with increased risk of adverse pregnancy outcomes: a population-based cohort study. BMC Med. 2020;18(1):15.
  10. Claire R, Chamberlain C, Davey MA, Cooper SE, Berlin I, Leonardi-Bee J et al. Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev. 2020;3(3):CD010078.
  11. Nörby U, Forsberg L, Wide K, Sjörs G, Winbladh B, Källén K. Neonatal Morbidity After Maternal Use of Antidepressant Drugs During Pregnancy. Pediatrics. 2016;138:.
  12. Rotem-Kohavi N, Williams LJ, Virji-Babul N, Bjornson BH, Brain U, Werker JF et al. Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4(1):39-49.
  13. Huybrechts KF, Bateman BT, Palmsten K, Desai RJ, Patorno E, Gopalakrishnan C et al. Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA. 2015;313(21):2142-51.
  14. Munk-Olsen T, Bergink V, Rommel AS, Momen N, Liu X. Association of Persistent Pulmonary Hypertension in Infants With the Timing and Type of Antidepressants In Utero. JAMA Netw Open. 2021;4(12):e2136639.