11/21/2024

Janusmed fosterpåverkan

Janusmed fosterpåverkan – Merkaptopurin

Janusmed fosterpåverkan tillhandahåller bedömningar av eventuella risker för fostret, när en gravid kvinna använder olika läkemedel. Observera att texterna är generella, och att en bedömning måste göras i varje enskilt fall. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

För att komma till startsidan för Janusmed fosterpåverkan och för att göra sökningar klicka här.

Tillbaka till index
2 2
2 2

Merkaptopurin

Merkaptopurin

Klass : 2

Visa all info

Skriv ut

Kontakta oss

  1. Ngu SF, Ngan HY. Chemotherapy in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2016;33(0):86-101.

  2. Boere I, Lok C, Vandenbroucke T, Amant F. Cancer in pregnancy: safety and efficacy of systemic therapies. Curr Opin Oncol. 2017;29(5):328-334.

  3. Lambertini M, Peccatori FA, Azim HA. Targeted agents for cancer treatment during pregnancy. Cancer Treat Rev. 2015;41(4):301-9.

  4. Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N, Network of French Pharmacovigilance Centers et al. Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study. Arthritis Rheumatol. 2014;66(5):1101-10.

  5. United Kingdom Teratology Information Services (UKTIS). Methotrexate in pregnancy. 2016. Tillgänglig från: www.toxbase.com. Hämtad: 2018-06-15

  6. Arnon J, Meirow D, Lewis-Roness H, Ornoy A. Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum Reprod Update. 2001;7(4):394-403.

  7. Haggar FA, Pereira G, Preen D, Holman CD, Einarsdottir K. Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: a population-based cohort study. PLoS One. 2014;9(12):e113292.

  8. Dohle GR. Male infertility in cancer patients: Review of the literature. Int J Urol. 2010;17(4):327-31.

  9. Scialli AR, Bailey G, Beyer BK, Bøgh IB, Breslin WJ, Chen CL et al. Potential seminal transport of pharmaceuticals to the conceptus. Reprod Toxicol. 2015;58(0):213-21.

  10. Klemmt L, Scialli AR. The transport of chemicals in semen. Birth Defects Res B Dev Reprod Toxicol. 2005;74(2):119-31.

  11. Cleary BJ, Källén B. Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A Clin Mol Teratol 2009;85:647-54.

  12. Chambers C, Koren G, Tutuncu ZN, Johnson D, Jones KL. Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study. Can Fam Physician 2007;53:409-12.

  13. Schardein JL. Chemically Induced Birth Defects. Marcel Dekker Inc., New York and Basel. 1985.

  14. Polifka JE, Friedman JM. Teratogen update: Azathioprine and 6-mercaptopurine. Teratology 2002;65:240-61.

  15. Mona Akbari et al. Systematic Review and Meta-Analysis on the Effects of Thiopurines on Birth Outcomes From Female and Male Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2013 Jan;19(1):15-22.

  16. Kanis SL, de Lima-Karagiannis A, de Boer NKH, van der Woude CJ. Use of Thiopurines During Conception and Pregnancy Is Not Associated With Adverse Pregnancy Outcomes or Health of Infants at One Year in a Prospective Study. Clin Gastroenterol Hepatol. 2017;15(8):1232-1241e1.

  17. Nguyen GC, Seow CH, Maxwell C, Huang V, Leung Y, Jones J et al. The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy. Gastroenterology. 2016;150(3):734-757e1.

  18. Belizna C, Meroni PL, Shoenfeld Y, Devreese K, Alijotas-Reig J, Esteve-Valverde E et al. In utero exposure to Azathioprine in autoimmune disease Where do we stand?. Autoimmun Rev. 2020;19(9):102525.

  19. J M Davison, H Dellagrammatikas, J M Parkin. Maternal Azathioprine Therapy and Depressed Haemopoiesis in the Babies of Renal Allograft Patients. Br J Obstet Gynaecol. 1985 Mar;92(3):233-9.

  20. C Thomas, C Monteil-Ganiere, S Mirallié, C Hémont, C Dert, A Léger, C Joyau, D Caldari, M Audrain . A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease. J Crohns Colitis. 2018;12(2):258-261.

  21. Coté CJ, Meuwissen HJ, Pickering RJ. Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy. J Pediatr. 1974;85(3):324-8.

  22. DeWitte DB, Buick MK, Cyran SE, Maisels MJ. Neonatal pancytopenia and severe combined immunodeficiency associated with antenatal administration of azathioprine and prednisone. J Pediatr. 1984;105(4):625-8.

  23. Jharap B, de Boer NK, Stokkers P, Hommes DW, Oldenburg B, et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut. 2014 Mar;63(3):451-7.

  24. Maruyama H, Tada K, Fujiwara T, Ota K, Kageyama M. Utility of maternal 6-thioguanine nucleotide levels in predicting neonatal pancytopenia. AJP Rep. 2013;3(1):25-8.

  25. FDA alerts health care professionals of pregnancy problems associated with thiopurines. FDA [www]. [updated 2024-04-29, cited 2024-11-12].

  26. Frank Wolf M, Sloma R, Akria L, Rimon E, Wiener Y, Carmiel Haggai M et al. Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature. Taiwan J Obstet Gynecol. 2023;62(5):761-764.

  1. Ngu SF, Ngan HY. Chemotherapy in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2016;33(0):86-101.
  2. Boere I, Lok C, Vandenbroucke T, Amant F. Cancer in pregnancy: safety and efficacy of systemic therapies. Curr Opin Oncol. 2017;29(5):328-334.
  3. Lambertini M, Peccatori FA, Azim HA. Targeted agents for cancer treatment during pregnancy. Cancer Treat Rev. 2015;41(4):301-9.
  4. Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N, Network of French Pharmacovigilance Centers et al. Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study. Arthritis Rheumatol. 2014;66(5):1101-10.
  5. United Kingdom Teratology Information Services (UKTIS). Methotrexate in pregnancy. 2016. Tillgänglig från: www.toxbase.com. Hämtad: 2018-06-15
  6. Arnon J, Meirow D, Lewis-Roness H, Ornoy A. Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum Reprod Update. 2001;7(4):394-403.
  7. Haggar FA, Pereira G, Preen D, Holman CD, Einarsdottir K. Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: a population-based cohort study. PLoS One. 2014;9(12):e113292.
  8. Dohle GR. Male infertility in cancer patients: Review of the literature. Int J Urol. 2010;17(4):327-31.
  9. Scialli AR, Bailey G, Beyer BK, Bøgh IB, Breslin WJ, Chen CL et al. Potential seminal transport of pharmaceuticals to the conceptus. Reprod Toxicol. 2015;58(0):213-21.
  10. Klemmt L, Scialli AR. The transport of chemicals in semen. Birth Defects Res B Dev Reprod Toxicol. 2005;74(2):119-31.
  11. Cleary BJ, Källén B. Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A Clin Mol Teratol 2009;85:647-54.
  12. Chambers C, Koren G, Tutuncu ZN, Johnson D, Jones KL. Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study. Can Fam Physician 2007;53:409-12.
  13. Schardein JL. Chemically Induced Birth Defects. Marcel Dekker Inc., New York and Basel. 1985.
  14. Polifka JE, Friedman JM. Teratogen update: Azathioprine and 6-mercaptopurine. Teratology 2002;65:240-61.
  15. Mona Akbari et al. Systematic Review and Meta-Analysis on the Effects of Thiopurines on Birth Outcomes From Female and Male Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2013 Jan;19(1):15-22.
  16. Kanis SL, de Lima-Karagiannis A, de Boer NKH, van der Woude CJ. Use of Thiopurines During Conception and Pregnancy Is Not Associated With Adverse Pregnancy Outcomes or Health of Infants at One Year in a Prospective Study. Clin Gastroenterol Hepatol. 2017;15(8):1232-1241e1.
  17. Nguyen GC, Seow CH, Maxwell C, Huang V, Leung Y, Jones J et al. The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy. Gastroenterology. 2016;150(3):734-757e1.
  18. Belizna C, Meroni PL, Shoenfeld Y, Devreese K, Alijotas-Reig J, Esteve-Valverde E et al. In utero exposure to Azathioprine in autoimmune disease Where do we stand?. Autoimmun Rev. 2020;19(9):102525.
  19. J M Davison, H Dellagrammatikas, J M Parkin. Maternal Azathioprine Therapy and Depressed Haemopoiesis in the Babies of Renal Allograft Patients. Br J Obstet Gynaecol. 1985 Mar;92(3):233-9.
  20. C Thomas, C Monteil-Ganiere, S Mirallié, C Hémont, C Dert, A Léger, C Joyau, D Caldari, M Audrain . A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease. J Crohns Colitis. 2018;12(2):258-261.
  21. Coté CJ, Meuwissen HJ, Pickering RJ. Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy. J Pediatr. 1974;85(3):324-8.
  22. DeWitte DB, Buick MK, Cyran SE, Maisels MJ. Neonatal pancytopenia and severe combined immunodeficiency associated with antenatal administration of azathioprine and prednisone. J Pediatr. 1984;105(4):625-8.
  23. Jharap B, de Boer NK, Stokkers P, Hommes DW, Oldenburg B, et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut. 2014 Mar;63(3):451-7.
  24. Maruyama H, Tada K, Fujiwara T, Ota K, Kageyama M. Utility of maternal 6-thioguanine nucleotide levels in predicting neonatal pancytopenia. AJP Rep. 2013;3(1):25-8.
  25. FDA alerts health care professionals of pregnancy problems associated with thiopurines. FDA [www]. [updated 2024-04-29, cited 2024-11-12].
  26. Frank Wolf M, Sloma R, Akria L, Rimon E, Wiener Y, Carmiel Haggai M et al. Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature. Taiwan J Obstet Gynecol. 2023;62(5):761-764.