apixaban - etoricoxib
apixaban - etoricoxib
Klass : C0
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apixaban
Enteral och parenteral
Eliquis (Filmdragerad tablett)
Eliquis (Filmdragerad tablett)etoricoxib
Enteral och parenteral
Medicinsk konsekvens
Risken för blödning ökar, särskilt gastrointestinala blödningar.
Risken för blödning ökar, särskilt gastrointestinala blödningar.Rekommendation
Kombinationen bör användas med försiktighet. För analgesi kan paracetamol vara ett bättre alternativ. Om samtidig behandling med acetylsalicylsyra/NSAID inte kan undvikas bör behandlingstiden för NSAID hållas så kort som möjligt och gastroprotektion med protonpumpshämmare kan övervägas.
Kombinationen bör användas med försiktighet. För analgesi kan paracetamol vara ett bättre alternativ. Om samtidig behandling med acetylsalicylsyra/NSAID inte kan undvikas bör behandlingstiden för NSAID hållas så kort som möjligt och gastroprotektion med protonpumpshämmare kan övervägas.Mechanism
Additive inhibitory effects on the hemostasic system, thro...... Visa hela mekanismtexten
Background
Co-treatment with apixaban and low-dose aspirin or clopido...... Visa hela bakgrundstexten
Referenser
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ELIQUIS (apixaban), Bistol-Meyers Squibb/Pfizer EEIG. SPC. 2011.
, Alexander JH, Becker RC, Bhatt DL, Cools F, Crea F et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009;119:2877-85.
Frost C, Shenker A, Gandhi MD, Pursley J, Barrett YC, Wang J et al. Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban. Br J Clin Pharmacol. 2014.
Lee MT, Park KY, Kim MS, et al. Concomitant Use of NSAIDs or SSRIs with NOACs Requires Monitoring for Bleeding. Yonsei Med J. 2020 Sep;61(9):741-9.
Dalgaard F, Mulder H, Wojdyla DM, et al. Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2020 Jan 7;141(1):10-2.
Kent AP, Brueckmann M, Fraessdorf M, et al. Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation. J Am Coll Cardiol. 2018 Jul 17;72(3):255-67.
Kreutz R, Haas S, Holberg G, Lassen MR, Mantovani LG, Schmidt A et al. Rivaroxaban compared with standard thromboprophylaxis after major orthopaedic surgery: co-medication interactions. Br J Clin Pharmacol. 2016;81:724-34.
Olsen AS, McGettigan P, Gerds TA, et al. Risk of gastrointestinal bleeding associated with oral anticoagulation and non-steroidal anti-inflammatory drugs in patients with atrial fibrillation: a nationwide study. Eur Heart J Cardiovasc Pharmacother. 2020 Sep 1;6(5):292-300.
- ELIQUIS (apixaban), Bistol-Meyers Squibb/Pfizer EEIG. SPC. 2011.
- , Alexander JH, Becker RC, Bhatt DL, Cools F, Crea F et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009;119:2877-85.
- Frost C, Shenker A, Gandhi MD, Pursley J, Barrett YC, Wang J et al. Evaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban. Br J Clin Pharmacol. 2014.
- Lee MT, Park KY, Kim MS, et al. Concomitant Use of NSAIDs or SSRIs with NOACs Requires Monitoring for Bleeding. Yonsei Med J. 2020 Sep;61(9):741-9.
- Dalgaard F, Mulder H, Wojdyla DM, et al. Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2020 Jan 7;141(1):10-2.
- Kent AP, Brueckmann M, Fraessdorf M, et al. Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation. J Am Coll Cardiol. 2018 Jul 17;72(3):255-67.
- Kreutz R, Haas S, Holberg G, Lassen MR, Mantovani LG, Schmidt A et al. Rivaroxaban compared with standard thromboprophylaxis after major orthopaedic surgery: co-medication interactions. Br J Clin Pharmacol. 2016;81:724-34.
- Olsen AS, McGettigan P, Gerds TA, et al. Risk of gastrointestinal bleeding associated with oral anticoagulation and non-steroidal anti-inflammatory drugs in patients with atrial fibrillation: a nationwide study. Eur Heart J Cardiovasc Pharmacother. 2020 Sep 1;6(5):292-300.