12/30/2024

Janusmed kön och genus

Janusmed kön och genus – levotyroxinnatrium (hydrat)

Janusmed kön och genus är ett kunskapsstöd som tillhandahåller information om köns- och genusaspekter på läkemedelsbehandling. Kunskapsstödet är avsedd främst för hälso- och sjukvårdspersonal. Texterna är generella och ska inte ses som behandlingsriktlinjer. Det är alltid behandlande läkare som ansvarar för patientens medicinering.

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C C
C C

Levotyroxin

Levotyroxin

Klass : C

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  1. Weetman AP. Graves' disease. N Engl J Med. 2000;343(17):1236-48.

  2. Smith TJ, Hegedüs L. Graves' Disease. N Engl J Med. 2016;375(16):1552-1565.

  3. Marinò M, Latrofa F, Menconi F, Chiovato L, Vitti P. Role of genetic and non-genetic factors in the etiology of Graves' disease. J Endocrinol Invest. 2015;38(3):283-94.

  4. Devdhar M, Drooger R, Pehlivanova M, Singh G, Jonklaas J. Levothyroxine replacement doses are affected by gender and weight, but not age. Thyroid. 2011;21:821-7.

  5. Heiat A, National Institutes of Health (NIH: the NIH Consensus Conference on Health Implications of Obesity in 1985), United States Department of Agriculture (the 1990 Department of Agriculture's Dietary Guidelines for Americans), National Heart, Lung, and Blood Institute. Impact of age on definition of standards for ideal weight. Prev Cardiol. 2003;6(2):104-7.

  6. Jonklaas J. Sex and age differences in levothyroxine dosage requirement. Endocr Pract. 2010;16:71-9.

  7. Yang T, Ruegger M, Colavecchia AC, Sadhu A, Patham B, Tatara A. Comparison of Levothyroxine Dosing in Patients with and without Heart Failure. Endocr Res. 2020;45(1):50-57.

  8. Arafah BM. Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med. 2001;344:1743-9.

  9. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081-125.

  10. Younis IR, Ahmed MA, Burman KD, Soldin OP, Jonklaas J. Stable Isotope Pharmacokinetic Studies Provide Insight into Effects of Age, Sex, and Weight on Levothyroxine Metabolism. Thyroid. 2018;28(1):41-49.

  11. Singh R. Determinants of levothyroxine dose required to achieve euthyroidism in pediatric population-a hospital-based prospective follow-up study. Eur J Pediatr. 2017;176(8):1027-1033.

  12. Mele C, Tagliaferri MA, Pagano L, Soranna D, Scacchi M, Aimaretti G et al. Levothyroxine Replacement in Obese Adults: The Role of Metabolic Variables and Aging on Thyroid Testing Abnormalities. J Clin Endocrinol Metab. 2019;104(12):6265-6274.

  13. Diker-Cohen T, Duskin-Bitan H, Shimon I, Hirsch D, Akirov A, Tsvetov G et al. DISEASE PRESENTATION AND REMISSION RATE IN GRAVES DISEASE TREATED WITH ANTITHYROID DRUGS: IS GENDER REALLY A FACTOR?. Endocr Pract. 2019;25(1):43-50.

  14. Schneider R, Reiners C. The effect of levothyroxine therapy on bone mineral density: a systematic review of the literature. Exp Clin Endocrinol Diabetes. 2003;111:455-70.

  15. Levoxyl (levothyroxine). DailyMed [www]. US National Library of Medicine. [updated 2020-12-15, cited 2021-11-10].

  16. Huang HK, Wang JH, Kao SL. Association of Hypothyroidism With All-Cause Mortality: A Cohort Study in an Older Adult Population. J Clin Endocrinol Metab. 2018;103(9):3310-3318.

  17. LEVAXIN (levotyroxin). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2020-02-04, cited 2021-11-20]

  18. Hadlow NC, Rothacker KM, Wardrop R, Brown SJ, Lim EM, Walsh JP. The relationship between TSH and free T₄ in a large population is complex and nonlinear and differs by age and sex. J Clin Endocrinol Metab. 2013;98:2936-43.

  19. Wildisen L, Feller M, Del Giovane C, Moutzouri E, Du Puy RS, Mooijaart SP et al. Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial. JAMA Netw Open. 2021;4(2):e2036645.

  20. Blum MR, Gencer B, Adam L, Feller M, Collet TH, da Costa BR et al. Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial. J Clin Endocrinol Metab. 2018;103(8):2988-2997.

  21. Pecina J, Garrison GM, Bernard ME. Levothyroxine dosage is associated with stability of thyroid-stimulating hormone values. Am J Med. 2014;127(3):240-5.

  22. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2020 [cited 2021-03-10.]

  1. Weetman AP. Graves' disease. N Engl J Med. 2000;343(17):1236-48.
  2. Smith TJ, Hegedüs L. Graves' Disease. N Engl J Med. 2016;375(16):1552-1565.
  3. Marinò M, Latrofa F, Menconi F, Chiovato L, Vitti P. Role of genetic and non-genetic factors in the etiology of Graves' disease. J Endocrinol Invest. 2015;38(3):283-94.
  4. Devdhar M, Drooger R, Pehlivanova M, Singh G, Jonklaas J. Levothyroxine replacement doses are affected by gender and weight, but not age. Thyroid. 2011;21:821-7.
  5. Heiat A, National Institutes of Health (NIH: the NIH Consensus Conference on Health Implications of Obesity in 1985), United States Department of Agriculture (the 1990 Department of Agriculture's Dietary Guidelines for Americans), National Heart, Lung, and Blood Institute. Impact of age on definition of standards for ideal weight. Prev Cardiol. 2003;6(2):104-7.
  6. Jonklaas J. Sex and age differences in levothyroxine dosage requirement. Endocr Pract. 2010;16:71-9.
  7. Yang T, Ruegger M, Colavecchia AC, Sadhu A, Patham B, Tatara A. Comparison of Levothyroxine Dosing in Patients with and without Heart Failure. Endocr Res. 2020;45(1):50-57.
  8. Arafah BM. Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med. 2001;344:1743-9.
  9. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081-125.
  10. Younis IR, Ahmed MA, Burman KD, Soldin OP, Jonklaas J. Stable Isotope Pharmacokinetic Studies Provide Insight into Effects of Age, Sex, and Weight on Levothyroxine Metabolism. Thyroid. 2018;28(1):41-49.
  11. Singh R. Determinants of levothyroxine dose required to achieve euthyroidism in pediatric population-a hospital-based prospective follow-up study. Eur J Pediatr. 2017;176(8):1027-1033.
  12. Mele C, Tagliaferri MA, Pagano L, Soranna D, Scacchi M, Aimaretti G et al. Levothyroxine Replacement in Obese Adults: The Role of Metabolic Variables and Aging on Thyroid Testing Abnormalities. J Clin Endocrinol Metab. 2019;104(12):6265-6274.
  13. Diker-Cohen T, Duskin-Bitan H, Shimon I, Hirsch D, Akirov A, Tsvetov G et al. DISEASE PRESENTATION AND REMISSION RATE IN GRAVES DISEASE TREATED WITH ANTITHYROID DRUGS: IS GENDER REALLY A FACTOR?. Endocr Pract. 2019;25(1):43-50.
  14. Schneider R, Reiners C. The effect of levothyroxine therapy on bone mineral density: a systematic review of the literature. Exp Clin Endocrinol Diabetes. 2003;111:455-70.
  15. Levoxyl (levothyroxine). DailyMed [www]. US National Library of Medicine. [updated 2020-12-15, cited 2021-11-10].
  16. Huang HK, Wang JH, Kao SL. Association of Hypothyroidism With All-Cause Mortality: A Cohort Study in an Older Adult Population. J Clin Endocrinol Metab. 2018;103(9):3310-3318.
  17. LEVAXIN (levotyroxin). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2020-02-04, cited 2021-11-20]
  18. Hadlow NC, Rothacker KM, Wardrop R, Brown SJ, Lim EM, Walsh JP. The relationship between TSH and free T₄ in a large population is complex and nonlinear and differs by age and sex. J Clin Endocrinol Metab. 2013;98:2936-43.
  19. Wildisen L, Feller M, Del Giovane C, Moutzouri E, Du Puy RS, Mooijaart SP et al. Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism: An Ancillary Study of a Randomized Clinical Trial. JAMA Netw Open. 2021;4(2):e2036645.
  20. Blum MR, Gencer B, Adam L, Feller M, Collet TH, da Costa BR et al. Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial. J Clin Endocrinol Metab. 2018;103(8):2988-2997.
  21. Pecina J, Garrison GM, Bernard ME. Levothyroxine dosage is associated with stability of thyroid-stimulating hormone values. Am J Med. 2014;127(3):240-5.
  22. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2020 [cited 2021-03-10.]