Vitamin B12 (cyanokobolamin och derivat)
Vitamin B12 (cyanokobolamin och derivat)
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B12 Ankermann, Behepan, Betolvan, Betolvex, Betolvidon, Novavita, VITA......
B12 Ankermann, Behepan, Betolvan, Betolvex, Betolvidon, Novavita, VITAMIN B12 ROTEXMEDICA, Vitamin B12ATC-koder
B03BA01
B03BA01Substanser
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cyanokobalamin, cyanokobalamin (0,1 % sd), cyanokobalamin (no.303 075/......
cyanokobalamin, cyanokobalamin (0,1 % sd), cyanokobalamin (no.303 075/1-82), cyanokobalamin (no.307420), cyanokobalamin(Co-57), cyanokobalanin-tanninkomplexSammanfattning
Multivitamintillskott innehållande vitamin B12 ökar blodnivåerna av vitamin B12 hos både kvinnor och män. Det saknas studier om skillnader mellan könen avseende biverkningar och farmakokinetik för vitamin B12.
Multivitamintillskott innehållande vitamin B12 ökar blodnivåerna av vitamin B12 hos både kvinnor och män. Det saknas studier om skillnader mellan könen avseende biverkningar och farmakokinetik för vitamin B12.Background
The main indications for vitamin B12 (cyanocobalamin) are treatment of pernicious anemia, long term use of medications such as L-DOPA which decreases B12-absorption, or neurologic deficits due to low B12-levels [1-4]. Visa hela bakgrundstexten
Vitamin B12 insufficiency leads to macrocytosis. A retrospective study (872 men, 1474 women) assessed the incidence of macrocytosis in men and women using a threshold of B12 of 0.16 nmol/L (160 pmol/L) in men and 0.11 nmol/L (110 pmol/L) in women respectively. Macrocytosis defined as a MCV > 100 fL was detected in 24 % of the men and 31% of the women [5].
Pharmacokinetics and dosing
No studies with a clinically relevant sex analysis regarding the pharmacokinetics of vitamin B12 have been found. There is no difference in recommended intake of vitamin B12 between men and women.
Effects
Data from two randomized, double-blind, placebo-controlled trials in healthy individuals (19 men, 28 women) aged 55-65 years, 16 weeks with a daily multivitamin supplementation containing 120 µg vitamin B12 for men and 115 µg B12 for women resulted in an increase of vitamin B12 levels......
Försäljning på recept
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Fler kvinnor än män hämtade ut läkemedel innehållande vitamin B12 (ATC-kod B03BA) på recept i Sverige år 2017, totalt 284 248 kvinnor och 176 411 män. Det motsvarar 57 respektive 35 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 85 år och äldre hos båda könen. Totalt sett var läkemedel innehållande vitamin B12 1,6 gånger vanligare hos kvinnor [17].
Referenser
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Green R. Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood. 2017;129(19):2603-2611.
Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014;349(1):g5226.
Stabler SP. Clinical practice Vitamin B12 deficiency. N Engl J Med. 2013;368(2):149-60.
Kumar N. Neurologic aspects of cobalamin (B12) deficiency. Handb Clin Neurol. 2014;120(1):915-26.
vant Sant P, Küsters PF, Harthoorn-Lasthuizen EJ. Dependency of MCV and haemoglobin concentration on plasma vitamin B12 levels in relation to sex and age. Clin Lab Haematol. 1997;19(1):27-31.
Harris E, Macpherson H, Pipingas A. Improved blood biomarkers but no cognitive effects from 16 weeks of multivitamin supplementation in healthy older adults. Nutrients. 2015;7(5):3796-812.
Castelli MC, Friedman K, Sherry J, Brazzillo K, Genoble L, Bhargava P et al. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther. 2011;33(3):358-371e2.
Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther. 2003;25(12):3124-34.
Dangour AD, Allen E, Clarke R, Elbourne D, Fletcher AE, Letley L et al. Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: a randomized controlled trial. Am J Clin Nutr. 2015;102(3):639-47.
Rogne T, Tielemans MJ, Chong MF, Yajnik CS, Krishnaveni GV, Poston L et al. Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. Am J Epidemiol. 2017;185(3):212-223.
Eussen SJ, Nilsen RM, Midttun Ø, Hustad S, IJssennagger N, Meyer K et al. North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Br J Nutr. 2013;110(2):363-74.
González-Gross M, Benser J, Breidenassel C, Albers U, Huybrechts I, Valtueña J et al. Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents: the Helena Study. Nutr Res. 2012;32(11):817-26.
Seppälä J, Koponen H, Kautiainen H, Eriksson JG, Kampman O, Leiviskä J et al. Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study. BMC Psychiatry. 2013;13(1):145.
Björkegren K, Svärdsudd K. Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study. J Intern Med. 2001;249(5):423-32.
Loikas S, Koskinen P, Irjala K, Löppönen M, Isoaho R, Kivelä SL et al. Vitamin B12 deficiency in the aged: a population-based study. Age Ageing. 2007;36(2):177-83.
Dhonukshe-Rutten RA, Lips M, de Jong N, Chin A Paw MJ, Hiddink GJ, van Dusseldorp M et al. Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr. 2003;133(3):801-7.
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2017 [cited 2018-12-06.]
- Green R. Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood. 2017;129(19):2603-2611.
- Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014;349(1):g5226.
- Stabler SP. Clinical practice Vitamin B12 deficiency. N Engl J Med. 2013;368(2):149-60.
- Kumar N. Neurologic aspects of cobalamin (B12) deficiency. Handb Clin Neurol. 2014;120(1):915-26.
- vant Sant P, Küsters PF, Harthoorn-Lasthuizen EJ. Dependency of MCV and haemoglobin concentration on plasma vitamin B12 levels in relation to sex and age. Clin Lab Haematol. 1997;19(1):27-31.
- Harris E, Macpherson H, Pipingas A. Improved blood biomarkers but no cognitive effects from 16 weeks of multivitamin supplementation in healthy older adults. Nutrients. 2015;7(5):3796-812.
- Castelli MC, Friedman K, Sherry J, Brazzillo K, Genoble L, Bhargava P et al. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther. 2011;33(3):358-371e2.
- Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther. 2003;25(12):3124-34.
- Dangour AD, Allen E, Clarke R, Elbourne D, Fletcher AE, Letley L et al. Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: a randomized controlled trial. Am J Clin Nutr. 2015;102(3):639-47.
- Rogne T, Tielemans MJ, Chong MF, Yajnik CS, Krishnaveni GV, Poston L et al. Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. Am J Epidemiol. 2017;185(3):212-223.
- Eussen SJ, Nilsen RM, Midttun Ø, Hustad S, IJssennagger N, Meyer K et al. North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Br J Nutr. 2013;110(2):363-74.
- González-Gross M, Benser J, Breidenassel C, Albers U, Huybrechts I, Valtueña J et al. Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents: the Helena Study. Nutr Res. 2012;32(11):817-26.
- Seppälä J, Koponen H, Kautiainen H, Eriksson JG, Kampman O, Leiviskä J et al. Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study. BMC Psychiatry. 2013;13(1):145.
- Björkegren K, Svärdsudd K. Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study. J Intern Med. 2001;249(5):423-32.
- Loikas S, Koskinen P, Irjala K, Löppönen M, Isoaho R, Kivelä SL et al. Vitamin B12 deficiency in the aged: a population-based study. Age Ageing. 2007;36(2):177-83.
- Dhonukshe-Rutten RA, Lips M, de Jong N, Chin A Paw MJ, Hiddink GJ, van Dusseldorp M et al. Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr. 2003;133(3):801-7.
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2017 [cited 2018-12-06.]
Uppdaterat
Litteratursökningsdatum: 12/1/2017
Litteratursökningsdatum: 12/1/2017