Tramadol
Tramadol
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Dolatramyl, Gemadol, Nobligan, Nobligan retard, Tiparol, Tiparol OD, T......
Dolatramyl, Gemadol, Nobligan, Nobligan retard, Tiparol, Tiparol OD, Tiparol Retard, Tradolan, Tradolan Retard, Tramadol 2care4, Tramadol Actavis, Tramadol Alternova, Tramadol Aurobindo, Tramadol HEXAL, Tramadol Krka, Tramadol Retard Actavis, Tramadol Retard Hexal, Tramadol Retard Krka, Tramadol Retard Medartuum, Tramadol Retard Mylan, Tramadol STADA, Tramadol Vitabalans, Tramuno, ZaldiarATC-koder
N02AJ13, N02AX02
N02AJ13, N02AX02Substanser
tramadol, tramadolhydroklorid
tramadol, tramadolhydrokloridSammanfattning
Studier visar likvärdig smärtlindrande effekt av tramadol hos kvinnor och män. Tramadol-inducerade krampanfall är en dosberoende biverkning hos både kvinnor och män.
Studier visar likvärdig smärtlindrande effekt av tramadol hos kvinnor och män. Tramadol-inducerade krampanfall är en dosberoende biverkning hos både kvinnor och män.Background
The prevalence of several clinical pain conditions is higher in women than in men. Differences in pharmacokinetics, sex hormones, stress response, or socio-cultural aspects may be of importance [1-3]. Therefore, sex and gender differences of pain medications are difficult to interpret [4]. Visa hela bakgrundstexten
Studies on abuse potential of opioids have not been included in this document.
Pharmacokinetics and dosing
A study in healthy Iranian volunteers (12 men, 12 women) showed no sex differences in pharmacokinetics of a single dose 100 mg tramadol [5]. The original manufacturer reports that for extended-release tramadol capsule, dose-normalized AUC values were slightly higher in healthy women than men [6, 7]. After a single oral dose of tramadol tablet, women had 12% higher peak tramadol concentration and 35% higher AUC (adjusted for body weight) [8].
In a prospective observational study in patients undergoing laparoscopic cholecystectomy (60 men, 60 women), women required a higher dose of tramadol during the first postoperative hour to achieve a similar degree of analgesia (40 mg vs. 27.8 mg). Baseli......
Försäljning på recept
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Fler kvinnor än män hämtade ut läkemedel innehållande tramadol (ATC-kod N02AX02) på recept i Sverige år 2021, totalt 31 600 kvinnor och 25 321 män. Det motsvarar 6,1 respektive 4,9 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 55-79 år hos båda könen. I genomsnitt var läkemedel innehållande tramadol 1,3 gånger vanligare hos kvinnor [16].
Referenser
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Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132 Suppl 1:S26-45.
Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52-8.
Sorge RE, Totsch SK. Sex Differences in Pain. J Neurosci Res. 2017;95(6):1271-1281.
Dance A. Why the sexes don't feel pain the same way. Nature. 2019;567(7749):448-450.
Ardakani YH, Rouini MR. Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers. Biopharm Drug Dispos. 2007;28:527-34.
Conzip. DailyMed [www]. US national Library of Medicine. [updated 2022-01-20, cited 2022-12-16].
Ultram. DailyMed [www]. US National Library of Medicine. [updated 2022-06-07, cited 2022-12-16].
Lintz W, Becker R, Gerloff J, Terlinden R. Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations 4th communication: drops (without ethanol). Arzneimittelforschung. 2000;50(2):99-108.
Hussain AM, Khan FA, Ahmed A, Chawla T, Azam SI. Effect of gender on pain perception and analgesic consumption in laparoscopic cholecystectomy: An observational study. J Anaesthesiol Clin Pharmacol. 2013;29:337-41.
Nobligan (tramadol). Summary of Product Characteristics. Medical Products Agency Sweden; 2014.
Malonne H, Coffiner M, Sonet B, Sereno A, Vanderbist F. Efficacy and tolerability of sustained-release tramadol in the treatment of symptomatic osteoarthritis of the hip or knee: a multicenter, randomized, double-blind, placebo-controlled study. Clin Ther. 2004;26:1774-82.
Pisanu C, Franconi F, Gessa GL, Mameli S, Pisanu GM, Campesi I et al. Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis. Pharmacol Res. 2019;148:104447.
Taghaddosinejad F, Mehrpour O, Afshari R, Seghatoleslami A, Abdollahi M, Dart RC. Factors related to seizure in tramadol poisoning and its blood concentration. J Med Toxicol. 2011;7:183-8.
Farajidana H, Hassanian-Moghaddam H, Zamani N, Sanaei-Zadeh H. Tramadol-induced seizures and trauma. Eur Rev Med Pharmacol Sci. 2012;16 Suppl 1:34-7.
Lopes GS, Bielinski S, Moyer AM, Jacobson DJ, Wang L, Jiang R et al. Sex differences in type and occurrence of adverse reactions to opioid analgesics: a retrospective cohort study. BMJ Open. 2021;11(6):e044157.
Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2021 [cited 2022-03-15.]
- Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132 Suppl 1:S26-45.
- Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52-8.
- Sorge RE, Totsch SK. Sex Differences in Pain. J Neurosci Res. 2017;95(6):1271-1281.
- Dance A. Why the sexes don't feel pain the same way. Nature. 2019;567(7749):448-450.
- Ardakani YH, Rouini MR. Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers. Biopharm Drug Dispos. 2007;28:527-34.
- Conzip. DailyMed [www]. US national Library of Medicine. [updated 2022-01-20, cited 2022-12-16].
- Ultram. DailyMed [www]. US National Library of Medicine. [updated 2022-06-07, cited 2022-12-16].
- Lintz W, Becker R, Gerloff J, Terlinden R. Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations 4th communication: drops (without ethanol). Arzneimittelforschung. 2000;50(2):99-108.
- Hussain AM, Khan FA, Ahmed A, Chawla T, Azam SI. Effect of gender on pain perception and analgesic consumption in laparoscopic cholecystectomy: An observational study. J Anaesthesiol Clin Pharmacol. 2013;29:337-41.
- Nobligan (tramadol). Summary of Product Characteristics. Medical Products Agency Sweden; 2014.
- Malonne H, Coffiner M, Sonet B, Sereno A, Vanderbist F. Efficacy and tolerability of sustained-release tramadol in the treatment of symptomatic osteoarthritis of the hip or knee: a multicenter, randomized, double-blind, placebo-controlled study. Clin Ther. 2004;26:1774-82.
- Pisanu C, Franconi F, Gessa GL, Mameli S, Pisanu GM, Campesi I et al. Sex differences in the response to opioids for pain relief: A systematic review and meta-analysis. Pharmacol Res. 2019;148:104447.
- Taghaddosinejad F, Mehrpour O, Afshari R, Seghatoleslami A, Abdollahi M, Dart RC. Factors related to seizure in tramadol poisoning and its blood concentration. J Med Toxicol. 2011;7:183-8.
- Farajidana H, Hassanian-Moghaddam H, Zamani N, Sanaei-Zadeh H. Tramadol-induced seizures and trauma. Eur Rev Med Pharmacol Sci. 2012;16 Suppl 1:34-7.
- Lopes GS, Bielinski S, Moyer AM, Jacobson DJ, Wang L, Jiang R et al. Sex differences in type and occurrence of adverse reactions to opioid analgesics: a retrospective cohort study. BMJ Open. 2021;11(6):e044157.
- Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2021 [cited 2022-03-15.]
Uppdaterat
Litteratursökningsdatum: 12/16/2022
Litteratursökningsdatum: 12/16/2022