12/25/2025

Janusmed kön och genus

Janusmed kön och genus – Tecentriq

Janusmed kön och genus är ett kunskapsstöd som tillhandahåller information om köns- och genusaspekter på läkemedelsbehandling. Kunskapsstödet är avsedd främst för hälso- och sjukvårdspersonal. Texterna är generella och ska inte ses som behandlingsriktlinjer. Det är alltid behandlande läkare som ansvarar för patientens medicinering.

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Atezolizumab

Atezolizumab

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  1. Li C, Lei S, Ding L, Xu Y, Wu X, Wang H et al. Global burden and trends of lung cancer incidence and mortality. Chin Med J (Engl). 2023;136(13):1583-1590.

  2. Lampimukhi M, Qassim T, Venu R, Pakhala N, Mylavarapu S, Perera T et al. A Review of Incidence and Related Risk Factors in the Development of Hepatocellular Carcinoma. Cureus. 2023;15(11):e49429.

  3. Pignot G, Barthélémy P, Borchiellini D. Sex Disparities in Bladder Cancer Diagnosis and Treatment. Cancers (Basel). 2024;16(23):.

  4. Tecentriq (atezolizumab). Summary of Product Characteristics. European Medicines Agency (EMA) [updated 2025-10-16, cited 2025-12-14]

  5. Marchand M, Zhang R, Chan P, Quarmby V, Ballinger M, Sternheim N et al. Time-dependent population PK models of single-agent atezolizumab in patients with cancer. Cancer Chemother Pharmacol. 2021;88(2):211-221.

  6. Liu W, Huo G, Chen P. Efficacy of Atezolizumab for Advanced Non-Small Cell Lung Cancer Based on Clinical and Molecular Features: A Meta-Analysis. Front Immunol. 2022;13:909027.

  7. Schneidewind L, Kiss B, Zengerling F, Borkowetz A, Graf S, Kranz J et al. Gender-specific outcomes in immune checkpoint inhibitor therapy for advanced or metastatic urothelial cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol. 2023;149(11):9399-9408.

  8. Liu SV, Reck M, Mansfield AS, Mok T, Scherpereel A, Reinmuth N et al. Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133). J Clin Oncol. 2021;39(6):619-630.

  9. May P, Winter C, Hubrecht I, Ortner E, Strathmeyer S, Geyer R et al. Metabolic phenotype and gender may predict treatment outcomes of atezolizumab in extensive-stage small cell lung cancer. Transl Lung Cancer Res. 2025;14(9):3836-3846.

  10. Mikami T, Liaw B, Asada M, Niimura T, Zamami Y, Green-LaRoche D et al. Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database. J Neurooncol. 2021;152(1):135-144.

  11. Shan W, Zhu J, Shen J. Gender and age disparities in cardiac immune-related adverse events associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FAERS database. BMJ Open. 2025;15(6):e090087.

  1. Li C, Lei S, Ding L, Xu Y, Wu X, Wang H et al. Global burden and trends of lung cancer incidence and mortality. Chin Med J (Engl). 2023;136(13):1583-1590.
  2. Lampimukhi M, Qassim T, Venu R, Pakhala N, Mylavarapu S, Perera T et al. A Review of Incidence and Related Risk Factors in the Development of Hepatocellular Carcinoma. Cureus. 2023;15(11):e49429.
  3. Pignot G, Barthélémy P, Borchiellini D. Sex Disparities in Bladder Cancer Diagnosis and Treatment. Cancers (Basel). 2024;16(23):.
  4. Tecentriq (atezolizumab). Summary of Product Characteristics. European Medicines Agency (EMA) [updated 2025-10-16, cited 2025-12-14]
  5. Marchand M, Zhang R, Chan P, Quarmby V, Ballinger M, Sternheim N et al. Time-dependent population PK models of single-agent atezolizumab in patients with cancer. Cancer Chemother Pharmacol. 2021;88(2):211-221.
  6. Liu W, Huo G, Chen P. Efficacy of Atezolizumab for Advanced Non-Small Cell Lung Cancer Based on Clinical and Molecular Features: A Meta-Analysis. Front Immunol. 2022;13:909027.
  7. Schneidewind L, Kiss B, Zengerling F, Borkowetz A, Graf S, Kranz J et al. Gender-specific outcomes in immune checkpoint inhibitor therapy for advanced or metastatic urothelial cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol. 2023;149(11):9399-9408.
  8. Liu SV, Reck M, Mansfield AS, Mok T, Scherpereel A, Reinmuth N et al. Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133). J Clin Oncol. 2021;39(6):619-630.
  9. May P, Winter C, Hubrecht I, Ortner E, Strathmeyer S, Geyer R et al. Metabolic phenotype and gender may predict treatment outcomes of atezolizumab in extensive-stage small cell lung cancer. Transl Lung Cancer Res. 2025;14(9):3836-3846.
  10. Mikami T, Liaw B, Asada M, Niimura T, Zamami Y, Green-LaRoche D et al. Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database. J Neurooncol. 2021;152(1):135-144.
  11. Shan W, Zhu J, Shen J. Gender and age disparities in cardiac immune-related adverse events associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FAERS database. BMJ Open. 2025;15(6):e090087.