Ranitidin
Ranitidin
Klass : A
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Produkter
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Artonil, Inside, Inside Brus, Rani-Q, Ranilin, Ranitidi......
Artonil, Inside, Inside Brus, Rani-Q, Ranilin, Ranitidin Actavis, Ranitidin Apofri, Ranitidin Mylan, Ranitidin Sandoz, Ranitidin-ratiopharm, Ranitidine, Ranitidine Alliance, Stomacid, Zantac, Zantac BrusATC-koder
A02BA02
A02BA02Substanser
ranitidin, ranitidinhydroklorid
ranitidin, ranitidinhydrokloridSammanfattning
De flesta studier har visat att ranitidin läker magsår i samma utsträckning hos kvinnor och män, men en studie har visat att kvinnor hade lägre återfallsfrekvens av magsår efter långtidsbehandling.
De flesta studier har visat att ranitidin läker magsår i samma utsträckning hos kvinnor och män, men en studie har visat att kvinnor hade lägre återfallsfrekvens av magsår efter långtidsbehandling.Background
Pharmacokinetics and dosing
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No sex differences in ranitidine pharmacokinetics were found in patients (8 men, 8 women) receiving 300 mg ranitidine [1]. One study has investigated if pharmacokinetic parameters of a single dose oral ranitidine differ in men and women in different phases of the menstrual cycle. Healthy volunteers (10 men, 10 women) received a single dose of 300 mg ranitidine. Differences were seen in women at different stages of the menstrual cycle. In the follicular phase distribution volume and total clearance was lower while AUC and maximum concentration was higher than in the luteal phase. Men had 56% higher AUC and 9% lower clearance than women in follicular phase [2]. Despite the pharmacokinetic differences of ranitidine, the clinical studies have shown the same effect with similar doses in men and women and no difference in dosing has been suggested [3].
Effects
A randomized, double-blind, placebo-controlled trial (99 men, 127 women) showed that 150 mg ranitidine for 48 weeks was more effective in maintaining healed gastric ulcers compared with placebo, in bo......
Försäljning på recept
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Läkemedel innehållande ranitidin (ATC-kod A02BA02) köps huvudsakligen receptfritt och därför saknas könsspecifika användningsdata [9].
Referenser
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Abad-Santos F, Carcas AJ, Guerra P, Govantes C, Montuenga C, Gómez E et al. Evaluation of sex differences in the pharmacokinetics of ranitidine in humans. J Clin Pharmacol. 1996;36:748-51.
Flores Pérez J, Juárez Olguín H, Flores Pérez C, Pérez Guillé G, Guillé Pérez A, Camacho Vieyra A et al. Effects of gender and phase of the menstrual cycle on the kinetics of ranitidine in healthy volunteers. Chronobiol Int. 2003;20:485-94.
Zantac (ranitidin). Summary of Product Characteristics. Swedish Medical Products Ageny; 2015.
Sue SO, Dawson DM, Brown JA, Wood DR, Kleoudis CS. Effectiveness of ranitidine 150 mg at bedtime as maintenance therapy for healed gastric ulcers. Clin Ther. 1996;18:1175-83.
Takemoto T, Sakaki N, Tsuneoka K, Namiki M, Ishikawa M, Oshiba S. Clinical usefulness of ranitidine in giant gastric ulcer. J Clin Gastroenterol. 1984;6:413-7.
Lee FI, Samloff IM, Hardman M. Comparison of tri-potassium di-citrato bismuthate tablets with ranitidine in healing and relapse of duodenal ulcers. Lancet. 1985;1:1299-302.
Koelz HR, Birchler R, Bretholz A, Bron B, Capitaine Y, Delmore G et al. Healing and relapse of reflux esophagitis during treatment with ranitidine. Gastroenterology. 1986;91:1198-205.
Penston JG, Dixon JS, Boyd EJ, Wormsley KG. A placebo-controlled investigation of duodenal ulcer recurrence after withdrawal of long-term treatment with ranitidine. Aliment Pharmacol Ther. 1993;7:259-65.
Conise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2021-11-18.]
- Abad-Santos F, Carcas AJ, Guerra P, Govantes C, Montuenga C, Gómez E et al. Evaluation of sex differences in the pharmacokinetics of ranitidine in humans. J Clin Pharmacol. 1996;36:748-51.
- Flores Pérez J, Juárez Olguín H, Flores Pérez C, Pérez Guillé G, Guillé Pérez A, Camacho Vieyra A et al. Effects of gender and phase of the menstrual cycle on the kinetics of ranitidine in healthy volunteers. Chronobiol Int. 2003;20:485-94.
- Zantac (ranitidin). Summary of Product Characteristics. Swedish Medical Products Ageny; 2015.
- Sue SO, Dawson DM, Brown JA, Wood DR, Kleoudis CS. Effectiveness of ranitidine 150 mg at bedtime as maintenance therapy for healed gastric ulcers. Clin Ther. 1996;18:1175-83.
- Takemoto T, Sakaki N, Tsuneoka K, Namiki M, Ishikawa M, Oshiba S. Clinical usefulness of ranitidine in giant gastric ulcer. J Clin Gastroenterol. 1984;6:413-7.
- Lee FI, Samloff IM, Hardman M. Comparison of tri-potassium di-citrato bismuthate tablets with ranitidine in healing and relapse of duodenal ulcers. Lancet. 1985;1:1299-302.
- Koelz HR, Birchler R, Bretholz A, Bron B, Capitaine Y, Delmore G et al. Healing and relapse of reflux esophagitis during treatment with ranitidine. Gastroenterology. 1986;91:1198-205.
- Penston JG, Dixon JS, Boyd EJ, Wormsley KG. A placebo-controlled investigation of duodenal ulcer recurrence after withdrawal of long-term treatment with ranitidine. Aliment Pharmacol Ther. 1993;7:259-65.
- Conise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2021-11-18.]
Uppdaterat
Litteratursökningsdatum: 6/12/2023
Litteratursökningsdatum: 6/12/2023