Prometazin
Prometazin
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Lergigan, Lergigan forte, Lergigan mite, Phenergan, Phenergan 2,5 %, P......
Lergigan, Lergigan forte, Lergigan mite, Phenergan, Phenergan 2,5 %, Phénergan, Prometazin Actavis, Promethazin-neuraxpharm, Promethazine Hydrochloride, Promethazine TevaATC-koder
R06AD02
R06AD02Substanser
prometazin, prometazinhydroklorid
prometazin, prometazinhydrokloridSammanfattning
Det saknas publicerade studier med kliniskt relevant analys av könsskillnader vad gäller effekt eller säkerhet av prometazin.
Det saknas publicerade studier med kliniskt relevant analys av könsskillnader vad gäller effekt eller säkerhet av prometazin.Background
Pharmacokinetics and dosing
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The pharmacokinetics of promethazine was evaluated in an open-label study with crossover design. Healthy subjects (18 men, 18 women) were randomized to two 12.5 mg suppositories, one 25 mg suppository, one 50 mg suppository, or 50 mg oral syrup. Promethazine pharmacokinetics was reported to be similar in men and women [1].
Effects
Promethazine and morphine as surgical premedication was evaluated in a double-blind study (96 men, 174 women). Patients were randomized to receive injections with either morphine 5 or 10 mg alone or in combination with promethazine 6.25 mg, 12.5 mg, or 25 mg. Promethazine 25 mg alone was also studied. The sedation level was assessed by a nurse at 15 and 30 minutes after injection and by the patient at 24h after surgery. The authors report that men in the study had lower mean sedation scores than women, however, this effect could be explained by weight as the men were heavier than the women [2].
The antiemetic efficacy of promethazine was evaluated based on medical records for 369 patients undergoing radiofrequency catheter......
Försäljning på recept
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Fler kvinnor än män hämtade ut läkemedel innehållande prometazin (ATC-kod R06AD02) på recept i Sverige år 2015, totalt 48 671 kvinnor och 23 039 män. Det motsvarar 9,9 respektive 4,7 personer per tusen invånare. I genomsnitt var läkemedel innehållande prometazin 2,0 gånger vanligare hos kvinnor [7].
Referenser
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Strenkoski-Nix LC, Ermer J, DeCleene S, Cevallos W, Mayer PR. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000;57:1499-505.
Conner JT, Bellville JW, Wender R, Wapner S, Dorey FJ, Katz RL. Morphine and promethazine as intravenous premedicants. Anesth Analg. 1977;56:801-7.
Tyndall A, Nyström KV, Funk M. Nausea and vomiting in patients undergoing radiofrequency catheter ablation. Am J Crit Care. 1997;6:437-44.
Page CB, Duffull SB, Whyte IM, Isbister GK. Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal. QJM. 2009;102:123-31.
Socialstyrelsen. Olämpliga läkemedel för äldre. Äldre och läkemedel [www]. [cited 2016-12-19].
Meurer WJ, Potti TA, Kerber KA, Sasson C, Macy ML, West BT et al. Potentially inappropriate medication utilization in the emergency department visits by older adults: analysis from a nationally representative sample. Acad Emerg Med. 2010;17:231-7.
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-12-19.]
- Strenkoski-Nix LC, Ermer J, DeCleene S, Cevallos W, Mayer PR. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000;57:1499-505.
- Conner JT, Bellville JW, Wender R, Wapner S, Dorey FJ, Katz RL. Morphine and promethazine as intravenous premedicants. Anesth Analg. 1977;56:801-7.
- Tyndall A, Nyström KV, Funk M. Nausea and vomiting in patients undergoing radiofrequency catheter ablation. Am J Crit Care. 1997;6:437-44.
- Page CB, Duffull SB, Whyte IM, Isbister GK. Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal. QJM. 2009;102:123-31.
- Socialstyrelsen. Olämpliga läkemedel för äldre. Äldre och läkemedel [www]. [cited 2016-12-19].
- Meurer WJ, Potti TA, Kerber KA, Sasson C, Macy ML, West BT et al. Potentially inappropriate medication utilization in the emergency department visits by older adults: analysis from a nationally representative sample. Acad Emerg Med. 2010;17:231-7.
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-12-19.]
Uppdaterat
Litteratursökningsdatum: 12/13/2016
Litteratursökningsdatum: 12/13/2016Se även
Morfin