Prednisolon – systemiskt
Prednisolon – systemiskt
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Okrido, Pediapred, Precortalon aquosum, Prednisolon 50 mg GALEN, Predn......
Okrido, Pediapred, Precortalon aquosum, Prednisolon 50 mg GALEN, Prednisolon APL, Prednisolon Actavis, Prednisolon Alternova, Prednisolon EQL Pharma, Prednisolon Ebb, Prednisolon JENAPHARM, Prednisolon Pfizer, Prednisolon Pilum, Prednisolone, Prednisolone Sodium Phosphate, Solu-Decortin, pms-PrednisoloneATC-koder
H02AB06
H02AB06Substanser
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prednisolon, prednisolonacetat, prednisolonkaproat, prednisolonnatrium......
prednisolon, prednisolonacetat, prednisolonkaproat, prednisolonnatriumfosfat, prednisolonnatriumsuccinat, prednisolonpivalatSammanfattning
En liten studie på infantil spasm visade något bättre effekt hos pojkar. I en studie på idiopatiskt nefrotiskt syndrom hade pojkar över 4 år bättre effekt av högre initialdos prednisolon.
En liten studie på infantil spasm visade något bättre effekt hos pojkar. I en studie på idiopatiskt nefrotiskt syndrom hade pojkar över 4 år bättre effekt av högre initialdos prednisolon.Background
Pharmacokinetics and dosing
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Prednisolone pharmacokinetics was investigated in healthy white and black men and women (16 men, 16 women) receiving a single oral dose 0.27 mg/kg of prednisone (precursor to prednisolone). Clearance of free prednisolone normalized for bodyweight was higher in men than women, regardless of race [4]. Contrary to this, another smaller study (4 men, 4 women) observed a higher total and free clearance in women after receiving prednisolone 0.075-1.5 mg/kg [5].
Effects
The response to prednisolone in children with infantile spasms has been evaluated (34 boys, 16 girls). Treatment with prednisolone was initiated at 2 mg/kg/day at lasted for maximum 6 weeks. Male sex was the only factor associated with favorable response [6].
A randomized controlled trial compared the efficacy of two different long-course treatment doses of prednisolone in children with idiopathic nephrotic syndrome (42 boys, 26 girls; age 1.5-14.4 years). Boys receiving the higher dose had higher rates of sustained remission than boys receiving the lower dose, especially for boys 4 years or......
Försäljning på recept
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Fler kvinnor än män hämtade ut läkemedel innehållande prednisolon (ATC-kod H02AB06) på recept i Sverige år 2015, totalt 140 121 kvinnor och 103 238 män. Det motsvarar 29 respektive 21 personer per tusen invånare. Andelen som hämtat ut läkemedel ökade med stigande ålder hos båda könen. I åldersgruppen 0-9 år var läkemedel innehållande prednisolon i genomsnitt 1,3 gånger vanligare hos pojkar och i åldersgruppen 10 år och äldre i genomsnitt 1,3 gånger vanligare hos flickor/kvinnor [12].
Referenser
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van Staa TP, Leufkens HG, Cooper C. The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int. 2002;13:777-87.
Donnan PT, Libby G, Boyter AC, Thompson P. The population risk of fractures attributable to oral corticosteroids. Pharmacoepidemiol Drug Saf. 2005;14:177-86.
Hansen KE, Kleker B, Safdar N, Bartels CM. A systematic review and meta-analysis of glucocorticoid-induced osteoporosis in children. Semin Arthritis Rheum. 2014;44:47-54.
Magee MH, Blum RA, Lates CD, Jusko WJ. Prednisolone pharmacokinetics and pharmacodynamics in relation to sex and race. J Clin Pharmacol. 2001;41:1180-94.
Meffin PJ, Brooks PM, Sallustio BC. Alterations in prednisolone disposition as a result of time of administration, gender and dose. Br J Clin Pharmacol. 1984;17:395-404.
Noureen N, Rana MT. Clinical profile and response to oral prednisolone in infantile spasm. J Coll Physicians Surg Pak. 2010;20:186-9.
Hiraoka M, Tsukahara H, Haruki S, Hayashi S, Takeda N, Miyagawa K et al. Older boys benefit from higher initial prednisolone therapy for nephrotic syndrome The West Japan Cooperative Study of Kidney Disease in Children. Kidney Int. 2000;58:1247-52.
Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA. Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study. Thorax. 2003;58:654-8.
Greene AK, Couto RA. Oral prednisolone for infantile hemangioma: efficacy and safety using a standardized treatment protocol. Plast Reconstr Surg. 2011;128:743-52.
Morin C, Fardet L. Systemic glucocorticoid therapy: risk factors for reported adverse events and beliefs about the drug A cross-sectional online survey of 820 patients. Clin Rheumatol. 2015;34:2119-26.
Kahaly GJ, Pitz S, Hommel G, Dittmar M. Randomized, single blind trial of intravenous versus oral steroid monotherapy in Graves' orbitopathy. J Clin Endocrinol Metab. 2005;90:5234-40.
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2017-01-26.]
- van Staa TP, Leufkens HG, Cooper C. The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int. 2002;13:777-87.
- Donnan PT, Libby G, Boyter AC, Thompson P. The population risk of fractures attributable to oral corticosteroids. Pharmacoepidemiol Drug Saf. 2005;14:177-86.
- Hansen KE, Kleker B, Safdar N, Bartels CM. A systematic review and meta-analysis of glucocorticoid-induced osteoporosis in children. Semin Arthritis Rheum. 2014;44:47-54.
- Magee MH, Blum RA, Lates CD, Jusko WJ. Prednisolone pharmacokinetics and pharmacodynamics in relation to sex and race. J Clin Pharmacol. 2001;41:1180-94.
- Meffin PJ, Brooks PM, Sallustio BC. Alterations in prednisolone disposition as a result of time of administration, gender and dose. Br J Clin Pharmacol. 1984;17:395-404.
- Noureen N, Rana MT. Clinical profile and response to oral prednisolone in infantile spasm. J Coll Physicians Surg Pak. 2010;20:186-9.
- Hiraoka M, Tsukahara H, Haruki S, Hayashi S, Takeda N, Miyagawa K et al. Older boys benefit from higher initial prednisolone therapy for nephrotic syndrome The West Japan Cooperative Study of Kidney Disease in Children. Kidney Int. 2000;58:1247-52.
- Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA. Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study. Thorax. 2003;58:654-8.
- Greene AK, Couto RA. Oral prednisolone for infantile hemangioma: efficacy and safety using a standardized treatment protocol. Plast Reconstr Surg. 2011;128:743-52.
- Morin C, Fardet L. Systemic glucocorticoid therapy: risk factors for reported adverse events and beliefs about the drug A cross-sectional online survey of 820 patients. Clin Rheumatol. 2015;34:2119-26.
- Kahaly GJ, Pitz S, Hommel G, Dittmar M. Randomized, single blind trial of intravenous versus oral steroid monotherapy in Graves' orbitopathy. J Clin Endocrinol Metab. 2005;90:5234-40.
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2017-01-26.]
Uppdaterat
Litteratursökningsdatum: 1/17/2017
Litteratursökningsdatum: 1/17/2017