12/30/2024

Janusmed kön och genus

Janusmed kön och genus – Levodopa/Benserazid Orifarm

Janusmed kön och genus är ett kunskapsstöd som tillhandahåller information om köns- och genusaspekter på läkemedelsbehandling. Kunskapsstödet är avsedd främst för hälso- och sjukvårdspersonal. Texterna är generella och ska inte ses som behandlingsriktlinjer. Det är alltid behandlande läkare som ansvarar för patientens medicinering.

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C! C!
C! C!

Levodopa + enzymhämmare (benserazid, karbidopa, entakapon)

Levodopa + enzymhämmare (benserazid, karbidopa, entakapon)

Klass : C!

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  1. Georgiev D, Hamberg K, Hariz M, Forsgren L, Hariz GM. Gender differences in Parkinson's disease: A clinical perspective. Acta Neurol Scand. 2017;136(6):570-584.

  2. Arabia G, Zappia M, Bosco D, Crescibene L, Bagalà A, Bastone L et al. Body weight, levodopa pharmacokinetics and dyskinesia in Parkinson's disease. Neurol Sci. 2002;23 Suppl 2:S53-4.

  3. Sharma JC, Bachmann CG, Linazasoro G. Classifying risk factors for dyskinesia in Parkinson's disease. Parkinsonism Relat Disord. 2010;16:490-7.

  4. Zappia M, Crescibene L, Arabia G, Nicoletti G, Bagalà A, Bastone L et al. Body weight influences pharmacokinetics of levodopa in Parkinson's disease. Clin Neuropharmacol. 2002;25:79-82.

  5. Kompoliti K, Adler CH, Raman R, Pincus JH, Leibowitz MT, Ferry JJ et al. Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics. Neurology. 2002;58(9):1418-22.

  6. Martinelli P, Contin M, Scaglione C, Riva R, Albani F, Baruzzi A. Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?. Neurol Sci. 2003;24:192-3.

  7. Kumagai T, Nagayama H, Ota T, Nishiyama Y, Mishina M, Ueda M. Sex differences in the pharmacokinetics of levodopa in elderly patients with Parkinson disease. Clin Neuropharmacol. 2014;37(6):173-6.

  8. Nyholm D, Karlsson E, Lundberg M, Askmark H. Large differences in levodopa dose requirement in Parkinson's disease: men use higher doses than women. Eur J Neurol. 2010;17:260-6.

  9. Baba Y, Putzke JD, Whaley NR, Wszolek ZK, Uitti RJ. Gender and the Parkinson's disease phenotype. J Neurol. 2005;252:1201-5.

  10. Altmann V, Schumacher-Schuh AF, Rieck M, Callegari-Jacques SM, Rieder CR, Hutz MH. Influence of genetic, biological and pharmacological factors on levodopa dose in Parkinson's disease. Pharmacogenomics. 2016;17(5):481-8.

  11. Hassin-Baer S, Molchadski I, Cohen OS, Nitzan Z, Efrati L, Tunkel O et al. Gender effect on time to levodopa-induced dyskinesias. J Neurol. 2011;258:2048-53.

  12. Zappia M, Annesi G, Nicoletti G, Arabia G, Annesi F, Messina D et al. Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. Arch Neurol. 2005;62:601-5.

  13. Kaasinen V, Nurmi E, Brück A, Eskola O, Bergman J, Solin O et al. Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: sex differences in the prefrontal cortex. Brain. 2001;124:1125-30.

  14. Allen RP, Earley CJ. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep. 1996;19:205-13.

  15. Murialdo G, Masturzo P, Carolei A, Polleri A. Dose and sex related effects of benserazide on prolactin secretion. Boll Soc Ital Biol Sper. 1979;55:373-7.

  16. Polleri A, Masturzo P, Murialdo G, Carolei A. Dose and sex related effects of aromatic aminoacids decarboxylase inhibitors on serum prolactin in humans. Acta Endocrinol (Copenh). 1980;93:7-12.

  17. Stalevo (levodopa, carbidopa, entacapone). DailyMed [www]. [updated 2020-01-07, cited 2020-01-16].

  18. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2019 [cited 2020-03-10.]

  1. Georgiev D, Hamberg K, Hariz M, Forsgren L, Hariz GM. Gender differences in Parkinson's disease: A clinical perspective. Acta Neurol Scand. 2017;136(6):570-584.
  2. Arabia G, Zappia M, Bosco D, Crescibene L, Bagalà A, Bastone L et al. Body weight, levodopa pharmacokinetics and dyskinesia in Parkinson's disease. Neurol Sci. 2002;23 Suppl 2:S53-4.
  3. Sharma JC, Bachmann CG, Linazasoro G. Classifying risk factors for dyskinesia in Parkinson's disease. Parkinsonism Relat Disord. 2010;16:490-7.
  4. Zappia M, Crescibene L, Arabia G, Nicoletti G, Bagalà A, Bastone L et al. Body weight influences pharmacokinetics of levodopa in Parkinson's disease. Clin Neuropharmacol. 2002;25:79-82.
  5. Kompoliti K, Adler CH, Raman R, Pincus JH, Leibowitz MT, Ferry JJ et al. Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics. Neurology. 2002;58(9):1418-22.
  6. Martinelli P, Contin M, Scaglione C, Riva R, Albani F, Baruzzi A. Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?. Neurol Sci. 2003;24:192-3.
  7. Kumagai T, Nagayama H, Ota T, Nishiyama Y, Mishina M, Ueda M. Sex differences in the pharmacokinetics of levodopa in elderly patients with Parkinson disease. Clin Neuropharmacol. 2014;37(6):173-6.
  8. Nyholm D, Karlsson E, Lundberg M, Askmark H. Large differences in levodopa dose requirement in Parkinson's disease: men use higher doses than women. Eur J Neurol. 2010;17:260-6.
  9. Baba Y, Putzke JD, Whaley NR, Wszolek ZK, Uitti RJ. Gender and the Parkinson's disease phenotype. J Neurol. 2005;252:1201-5.
  10. Altmann V, Schumacher-Schuh AF, Rieck M, Callegari-Jacques SM, Rieder CR, Hutz MH. Influence of genetic, biological and pharmacological factors on levodopa dose in Parkinson's disease. Pharmacogenomics. 2016;17(5):481-8.
  11. Hassin-Baer S, Molchadski I, Cohen OS, Nitzan Z, Efrati L, Tunkel O et al. Gender effect on time to levodopa-induced dyskinesias. J Neurol. 2011;258:2048-53.
  12. Zappia M, Annesi G, Nicoletti G, Arabia G, Annesi F, Messina D et al. Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. Arch Neurol. 2005;62:601-5.
  13. Kaasinen V, Nurmi E, Brück A, Eskola O, Bergman J, Solin O et al. Increased frontal [(18)F]fluorodopa uptake in early Parkinson's disease: sex differences in the prefrontal cortex. Brain. 2001;124:1125-30.
  14. Allen RP, Earley CJ. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep. 1996;19:205-13.
  15. Murialdo G, Masturzo P, Carolei A, Polleri A. Dose and sex related effects of benserazide on prolactin secretion. Boll Soc Ital Biol Sper. 1979;55:373-7.
  16. Polleri A, Masturzo P, Murialdo G, Carolei A. Dose and sex related effects of aromatic aminoacids decarboxylase inhibitors on serum prolactin in humans. Acta Endocrinol (Copenh). 1980;93:7-12.
  17. Stalevo (levodopa, carbidopa, entacapone). DailyMed [www]. [updated 2020-01-07, cited 2020-01-16].
  18. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2019 [cited 2020-03-10.]