Dimetylfumarat
Dimetylfumarat
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Dimethyl Fumarate Mylan, Dimethyl Fumarate Polpharma, D......
Dimethyl Fumarate Mylan, Dimethyl Fumarate Polpharma, Dimethyl fumarate Neuraxpharm, Fumaderm, Fumaderm Initial, Skilarence, TecfideraATC-koder
D05BX51, L04AX07
D05BX51, L04AX07Substanser
dimetylfumarat
dimetylfumaratSammanfattning
Vid skovvis förlöpande Multipel Skleros har den skovförebyggande effekten av dimetylfumarat visats vara bättre än placebo hos både kvinnor och män. I CONFIRM studien fann man dock att effekten avseende handikapp-progression vid två år var signifikant lägre hos män behandlade med dimetylfumarat jämfört med placebo. Hos kvinnor var skillnaden inte signifikant. Inga data avseende könsskillnader i biverkningar har hittats.
Vid skovvis förlöpande Multipel Skleros har den skovförebyggande effekten av dimetylfumarat visats vara bättre än placebo hos både kvinnor och män. I CONFIRM studien fann man dock att effekten avseende handikapp-progression vid två år var signifikant lägre hos män behandlade med dimetylfumarat jämfört med placebo. Hos kvinnor var skillnaden inte signifikant. Inga data avseende könsskillnader i biverkningar har hittats.Background
Multiple Sclerosis (MS) is more common in women than in men [1, 2]. The gender gap in prevalence has been increasing and is today estimated to be two to three times more common in women than in men [1-3]. Visa hela bakgrundstexten
Several risk factors of MS have been suggested to have a larger impact on women. Sunlight deprivation, vitamin D deficiency, overweight, low urate levels, and smoking are such risk factors that increase the risk more in women than in men. Suggested mechanisms are that smoking yields increased levels of mature peripheral functioning T cells (OKT3+) in women [1]. Men have a worse prognosis and the role of sex hormones have been discussed [1, 2].
In a biomarker study of MS patients (30 men, 70 women) and healthy controls (24 men, 51 women), insulin growth factor binding protein1 (IGFBP1) was higher in women with MS compared to men [4]. The authors suggest this could reflect different MS progression pathways in men and women.
Pharmacokinetics and dosing
According to the producer patient age or sex do not affect pharmacokinetic properties of dimethyl fumarate [7]. Bodyweight was foun......
Försäljning på recept
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Fler kvinnor än män hämtade ut läkemedel innehållande dimetylfumarat (ATC-kod N07XX09) på recept i Sverige år 2016, totalt 1 151 kvinnor och 484 män [11].
Referenser
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Bove R, Chitnis T. The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis. Mult Scler. 2014;20:520-6.
Voskuhl RR, Gold SM. Sex-related factors in multiple sclerosis susceptibility and progression. Nat Rev Neurol. 2012;8:255-63.
Johnson KM, Zhou H, Lin F, Ko JJ, Herrera V. Real-World Adherence and Persistence to Oral Disease-Modifying Therapies in Multiple Sclerosis Patients Over 1 Year. J Manag Care Spec Pharm. 2017;23:844-852.
Al-Temaimi R, AbuBaker J, Al-Khairi I, Alroughani R. Remyelination modulators in multiple sclerosis patients. Exp Mol Pathol. 2017;103(3):237-241.
Vlahiotis A, Sedjo R, Cox ER, Burroughs TE, Rauchway A, Lich R. Gender differences in self-reported symptom awareness and perceived ability to manage therapy with disease-modifying medication among commercially insured multiple sclerosis patients. J Manag Care Pharm. 2010;16:206-16.
Fox RJ, Salter A, Alster JM, Dawson NV, Kattan MW, Miller D et al. Risk tolerance to MS therapies: Survey results from the NARCOMS registry. Mult Scler Relat Disord. 2015;4(3):241-9.
Tecfidera (dimetylfumarat). Summary of Product Characteristics. European Medicines Agency (EMA). 2017.
Hutchinson M, Fox RJ, Miller DH, Phillips JT, Kita M, Havrdova E et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the CONFIRM study. J Neurol. 2013;260:2286-96.
Bar-Or A, Gold R, Kappos L, Arnold DL, Giovannoni G, Selmaj K et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study. J Neurol. 2013;260:2297-305.
Zhu B, Nestorov I, Zhao G, Meka V, Leahy M, Kam J et al. Evaluation of Potential Drug-Drug Interaction Between Delayed-Release Dimethyl Fumarate and a Commonly Used Oral Contraceptive (Norgestimate/Ethinyl Estradiol) in Healthy Women. Clin Pharmacol Drug Dev. 2017;6:604-613.
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2016 [cited 2017-12-08.]
- Bove R, Chitnis T. The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis. Mult Scler. 2014;20:520-6.
- Voskuhl RR, Gold SM. Sex-related factors in multiple sclerosis susceptibility and progression. Nat Rev Neurol. 2012;8:255-63.
- Johnson KM, Zhou H, Lin F, Ko JJ, Herrera V. Real-World Adherence and Persistence to Oral Disease-Modifying Therapies in Multiple Sclerosis Patients Over 1 Year. J Manag Care Spec Pharm. 2017;23:844-852.
- Al-Temaimi R, AbuBaker J, Al-Khairi I, Alroughani R. Remyelination modulators in multiple sclerosis patients. Exp Mol Pathol. 2017;103(3):237-241.
- Vlahiotis A, Sedjo R, Cox ER, Burroughs TE, Rauchway A, Lich R. Gender differences in self-reported symptom awareness and perceived ability to manage therapy with disease-modifying medication among commercially insured multiple sclerosis patients. J Manag Care Pharm. 2010;16:206-16.
- Fox RJ, Salter A, Alster JM, Dawson NV, Kattan MW, Miller D et al. Risk tolerance to MS therapies: Survey results from the NARCOMS registry. Mult Scler Relat Disord. 2015;4(3):241-9.
- Tecfidera (dimetylfumarat). Summary of Product Characteristics. European Medicines Agency (EMA). 2017.
- Hutchinson M, Fox RJ, Miller DH, Phillips JT, Kita M, Havrdova E et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the CONFIRM study. J Neurol. 2013;260:2286-96.
- Bar-Or A, Gold R, Kappos L, Arnold DL, Giovannoni G, Selmaj K et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study. J Neurol. 2013;260:2297-305.
- Zhu B, Nestorov I, Zhao G, Meka V, Leahy M, Kam J et al. Evaluation of Potential Drug-Drug Interaction Between Delayed-Release Dimethyl Fumarate and a Commonly Used Oral Contraceptive (Norgestimate/Ethinyl Estradiol) in Healthy Women. Clin Pharmacol Drug Dev. 2017;6:604-613.
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2016 [cited 2017-12-08.]
Uppdaterat
Litteratursökningsdatum 12/7/2017
Litteratursökningsdatum 12/7/2017