Fluorouracil - intravenöst
Fluorouracil - intravenöst
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Efudix, Efudix 5% cream, Efudix MEDA Pharma, Efudix MED......
Efudix, Efudix 5% cream, Efudix MEDA Pharma, Efudix MEDA Pharma GmbH, Efudix Meda, Efudix cream, Fluorouracil Accord, Fluorouracil Sandoz, Fluorouracil Teva, Fluorouracil-Teva, Flurablastin, TolakATC-koder
L01BC02
L01BC02Substanser
fluorouracil, fluorouracilnatrium
fluorouracil, fluorouracilnatriumSammanfattning
Kvinnligt kön är korrelerat med högre risk för biverkningar av 5-fluorouracil (5-FU). Könsskillnader i farmakokinetiken för 5-FU som infusion har noterats och några studier pekar på ökad exponering för 5-FU hos kvinnor. Någon könsrelaterad skillnad i utfall har dock inte setts för 5-FU ensamt eller i kombinationsbehandling.
Kvinnligt kön är korrelerat med högre risk för biverkningar av 5-fluorouracil (5-FU). Könsskillnader i farmakokinetiken för 5-FU som infusion har noterats och några studier pekar på ökad exponering för 5-FU hos kvinnor. Någon könsrelaterad skillnad i utfall har dock inte setts för 5-FU ensamt eller i kombinationsbehandling.Background
Since chemotherapeutic agents share some adverse effects, evaluation of a particular agent’s safety during combination chemotherapy is complicated. Visa hela bakgrundstexten
Pharmacokinetics and dosing
A pharmacokinetic study on patients (301 men, 79 women) showed a wide variability in the clearance rate of 5-FU (L/h/m2) among both men and women, and a significantly faster clearance rate in men (median 179; range 29-739, vs median 155; range 56-466) [1] .
Results of a prospective population pharmacokinetic study showed sex-specific elimination of continuous-infusional 5-FU in patients with gastrointestinal malignancies (21 men, 10 women). Men had a 26% higher elimination of 5-FU, and lower AUC of 5-FU compared to women (18 vs. 22 mg h/L) [2].
Effects
A pooled analysis from five5 randomized clinical trials of metastatic colorectal cancer patients (1925 men, 1298 women) who were mainly treated with FOLFOX (folinic acid, fluorouracil, and oxaliplatin)-based regimens found no difference in overall survival, or progression-free survival between men and women [3].
Adverse effects
An analysis of five randomiz......
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Läkemedel innehållande fluorouracil (ATC-kod L01BC02) används huvudsakligen på sjukhus och därför saknas könsspecifika användningsdata [7].
Referenser
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Milano G, Etienne MC, Cassuto-Viguier E, Thyss A, Santini J, Frenay M et al. Influence of sex and age on fluorouracil clearance. J Clin Oncol. 1992;10(7):1171-5.
Mueller F, Büchel B, Köberle D, Schürch S, Pfister B, Krähenbühl S, Froehlich TK, Largiader CR, Joerger M. Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study. Cancer Chemother Pharmacol. 2013;71(2):361-70.
Abdel-Rahman O. Impact of Sex on Chemotherapy Toxicity and Efficacy Among Patients With Metastatic Colorectal Cancer: Pooled Analysis of 5 Randomized Trials. Clin Colorectal Cancer. 2019;18(2):110-115.
Van Cutsem E, Labianca R, Bodoky G, Barone C, Aranda E, Nordlinger B et al. Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. J Clin Oncol. 2009;27(19):3117-25.
Tejpar S, Yan P, Piessevaux H, Dietrich D, Brauchli P, Klingbiel D et al. Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial. Eur J Cancer. 2018;99:66-77.
Fluorouracil Accord (fluorouracil). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2020-12-16, cited 2021-06-03]
Concise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2019-03-14.]
- Milano G, Etienne MC, Cassuto-Viguier E, Thyss A, Santini J, Frenay M et al. Influence of sex and age on fluorouracil clearance. J Clin Oncol. 1992;10(7):1171-5.
- Mueller F, Büchel B, Köberle D, Schürch S, Pfister B, Krähenbühl S, Froehlich TK, Largiader CR, Joerger M. Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study. Cancer Chemother Pharmacol. 2013;71(2):361-70.
- Abdel-Rahman O. Impact of Sex on Chemotherapy Toxicity and Efficacy Among Patients With Metastatic Colorectal Cancer: Pooled Analysis of 5 Randomized Trials. Clin Colorectal Cancer. 2019;18(2):110-115.
- Van Cutsem E, Labianca R, Bodoky G, Barone C, Aranda E, Nordlinger B et al. Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. J Clin Oncol. 2009;27(19):3117-25.
- Tejpar S, Yan P, Piessevaux H, Dietrich D, Brauchli P, Klingbiel D et al. Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial. Eur J Cancer. 2018;99:66-77.
- Fluorouracil Accord (fluorouracil). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2020-12-16, cited 2021-06-03]
- Concise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2019-03-14.]
Uppdaterat
Litteratursökningsdatum 3/6/2021
Litteratursökningsdatum 3/6/2021