Duloxetin
Duloxetin
Klass : C
Visa all info
Skriv ut
Kontakta oss
Produkter
Visa alla produkter
Ariclaim, Aritavi, CYMBALTA, Duloxetin Actavis, Duloxetin Amarox, Dulo......
Ariclaim, Aritavi, CYMBALTA, Duloxetin Actavis, Duloxetin Amarox, Duloxetin Ebb, Duloxetin Pensa, Duloxetin STADA, Duloxetine Accord, Duloxetine Accordpharma, Duloxetine Aristo, Duloxetine Krka, Duloxetine Medical Valley, Duloxetine Mylan, Duloxetine Orion, Duloxetine Sandoz, Duloxetine Teva, Duloxetine Zentiva, Loxentia, YENTREVEATC-koder
N06AX21
N06AX21Substanser
duloxetin, duloxetinhydroklorid
duloxetin, duloxetinhydrokloridSammanfattning
Ett fåtal studier indikerar bättre effekt hos kvinnor för behandling vid egentlig depression samt smärtbehandling vid samtidig egentlig depression. Högre frekvens av muntorrhet och trötthet har rapporterats hos kvinnor. Lägre plasmakoncentration av duloxetin hos män jämfört med kvinnor har påvisats, men doseringsanvisningarna är samma för kvinnor och män.
Ett fåtal studier indikerar bättre effekt hos kvinnor för behandling vid egentlig depression samt smärtbehandling vid samtidig egentlig depression. Högre frekvens av muntorrhet och trötthet har rapporterats hos kvinnor. Lägre plasmakoncentration av duloxetin hos män jämfört med kvinnor har påvisats, men doseringsanvisningarna är samma för kvinnor och män.Background
Duloxetine is indicated to use in adults for management of major depressive disorder (MDD), generalized anxiety disorder (GAD) and diabetic peripheral neuropathic pain [7]. It is also indicated for the treatment of moderate to severe stress urinary incontinence in adult women [8]. Duloxetine is not approved for the treatment of fibromyalgia in Europe. Visa hela bakgrundstexten
Depression is almost twice as common in women as in men [1]. Women have an earlier age of onset and increased duration of depressive episodes. Differences in neurobiology [2, 3], hormones, inflammatory markers, diagnostic tools, or health seeking behavior [4, 5] may be of importance. Although depression is more prevalent in women, most preclinical studies on depression have used male animals [2] and the clinical implication of this is unclear.
Women are two to three times more likely to suffer from an anxiety disorder [1]. Sex differences in symptomatology and comorbidity may be due to genetic, hormonal, neurodevelopmental, environmental, and neurobiological factors [6].
Painful diabetic neuropathy is more common in women than in men (5......
Försäljning på recept
Visa hela försäljning på recept
Fler kvinnor än män hämtade ut läkemedel innehållande duloxetin (ATC-kod N06AX21) på recept i Sverige är 2021, totalt 44 097 kvinnor och 20 246 män. Det motsvarar 9 respektive 4 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 50-64 år hos kvinnor och i åldersgruppen 75-84 år hos män. I genomsnitt var läkemedel innehållande duloxetin 2,2 gånger vanligare hos kvinnor [29].
Referenser
Visa referenser
Cymbalta (duloxetine). Summary of Product Characteristics. European Medicines Agency [updated 2021-12-21, cited 2022-02-17]
Yentreve (duloxetine). Summary of Product Characteristics. European Medicines Agency [updated 2021-12-21, cited 2022-02-21]
Nationella riktlinjer för vård vid depression och ångestsyndrom 2021. Socialstyrelsen [www]. Socialstyrelsen. [updated 2021-04-01, cited 2021-05-14].
LeGates TA, Kvarta MD, Thompson SM. Sex differences in antidepressant efficacy. Neuropsychopharmacology. 2019;44(1):140-154.
Sramek JJ, Murphy MF, Cutler NR. Sex differences in the psychopharmacological treatment of depression. Dialogues Clin Neurosci. 2016;18(4):447-457.
Kerber CS, Dyck MJ, Culp KR, Buckwalter K. Antidepressant treatment of depression in rural nursing home residents. Issues Ment Health Nurs. 2008;29(9):959-73.
Labaka A, Goñi-Balentziaga O, Lebeña A, Pérez-Tejada J. Biological Sex Differences in Depression: A Systematic Review. Biol Res Nurs. 2018;20(4):383-392.
Jalnapurkar I, Allen M, Pigott T. Sex Differences in Anxiety Disorders: A Review. J Psychiatr Depress Anxiety. 2018;4(1):2-9.
Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the UK. Diabetes Care. 2011;34(10):2220-4.
Tianmei S, Knadler MP, Lim MT, Yeo KP, Teng L, Liang S et al. Pharmacokinetics and tolerability of duloxetine following oral administration to healthy Chinese subjects. Clin Pharmacokinet. 2007;46(9):767-75.
Lobo ED, Quinlan T, O'Brien L, Knadler MP, Heathman M. Population pharmacokinetics of orally administered duloxetine in patients: implications for dosing recommendation. Clin Pharmacokinet. 2009;48(3):189-97.
Lobo ED, Quinlan T, Prakash A. Pharmacokinetics of orally administered duloxetine in children and adolescents with major depressive disorder. Clin Pharmacokinet. 2014;53(8):731-40.
Kornstein SG, Wohlreich MM, Mallinckrodt CH, Watkin JG, Stewart DE. Duloxetine efficacy for major depressive disorder in male vs female patients: data from 7 randomized, double-blind, placebo-controlled trials. J Clin Psychiatry. 2006;67(5):761-70.
Howland RH, Wilson MG, Kornstein SG, Clayton AH, Trivedi MH, Wohlreich MM et al. Factors predicting reduced antidepressant response: experience with the SNRI duloxetine in patients with major depression. Ann Clin Psychiatry. 2008;20(4):209-18.
Wohlreich MM, Wiltse CG, Desaiah D, Ye W, Robinson RL, Kroenke K et al. Duloxetine in practice-based clinical settings: assessing effects on the emotional and physical symptoms of depression in an open-label, multicenter study. Prim Care Companion J Clin Psychiatry. 2007;9(4):271-9.
Mallinckrodt CH, Watkin JG, Liu C, Wohlreich MM, Raskin J. Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features. BMC Psychiatry. 2005;5:1.
Marchettini P, Wilhelm S, Petto H, Tesfaye S, Tölle T, Bouhassira D et al. Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy?. Eur J Pain. 2016;20(3):472-82.
Ziegler D, Pritchett YL, Wang F, Desaiah D, Robinson MJ, Hall JA et al. Impact of disease characteristics on the efficacy of duloxetine in diabetic peripheral neuropathic pain. Diabetes Care. 2007;30(3):664-9.
Velasco R, Besora S, Argyriou AA, Santos C, Sala R, Izquierdo C et al. Duloxetine against symptomatic chemotherapy-induced peripheral neurotoxicity in cancer survivors: a real world, open-label experience. Anticancer Drugs. 2021;32(1):88-94.
Arnold LM. Duloxetine and other antidepressants in the treatment of patients with fibromyalgia. Pain Med. 2007;8 Suppl 2:S63-74.
Arnold LM, Lu Y, Crofford LJ, Wohlreich M, Detke MJ, Iyengar S et al. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum. 2004;50(9):2974-84.
Brunton S, Wang F, Edwards SB, Crucitti AS, Ossanna MJ, Walker DJ et al. Profile of adverse events with duloxetine treatment: a pooled analysis of placebo-controlled studies. Drug Saf. 2010;33(5):393-407.
Stewart DE, Wohlreich MM, Mallinckrodt CH, Watkin JG, Kornstein SG. Duloxetine in the treatment of major depressive disorder: comparisons of safety and tolerability in male and female patients. J Affect Disord. 2006;94(1):183-9.
Delgado PL, Brannan SK, Mallinckrodt CH, Tran PV, McNamara RK, Wang F et al. Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. J Clin Psychiatry. 2005;66(6):686-92.
Montejo AL, Perahia DG, Spann ME, Wang F, Walker DJ, Yang CR et al. Sexual function during long-term duloxetine treatment in patients with recurrent major depressive disorder. J Sex Med. 2011;8(3):773-82.
Revol R, Rault C, Polard E, Bellet F, Guy C. [Hyponatremia associated with SSRI/NRSI: Descriptive and comparative epidemiological study of the incidence rates of the notified cases from the data of the French National Pharmacovigilance Database and the French National Health Insurance]. Encephale. 2018;44(3):291-296.
Mohan S, Gu S, Parikh A, Radhakrishnan J. Prevalence of hyponatremia and association with mortality: results from NHANES. Am J Med. 2013;126(12):1127-37e1.
Forns J, Pottegård A, Reinders T, Poblador-Plou B, Morros R, Brandt L et al. Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators. J Affect Disord. 2019;249:242-252.
Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2021 [cited 2022-03-15.]
Nationella riktlinjer för vård vid depression och ångestsyndrom 2021. Socialstyrelsen [www]. Socialstyrelsen. [updated 2021-04-01, cited 2021-05-14].
LeGates TA, Kvarta MD, Thompson SM. Sex differences in antidepressant efficacy. Neuropsychopharmacology. 2019;44(1):140-154.
Sramek JJ, Murphy MF, Cutler NR. Sex differences in the psychopharmacological treatment of depression. Dialogues Clin Neurosci. 2016;18(4):447-457.
Kerber CS, Dyck MJ, Culp KR, Buckwalter K. Antidepressant treatment of depression in rural nursing home residents. Issues Ment Health Nurs. 2008;29(9):959-73.
Labaka A, Goñi-Balentziaga O, Lebeña A, Pérez-Tejada J. Biological Sex Differences in Depression: A Systematic Review. Biol Res Nurs. 2018;20(4):383-392.
Jalnapurkar I, Allen M, Pigott T. Sex Differences in Anxiety Disorders: A Review. J Psychiatr Depress Anxiety. 2018;4(1):2-9.
- Cymbalta (duloxetine). Summary of Product Characteristics. European Medicines Agency [updated 2021-12-21, cited 2022-02-17]
- Yentreve (duloxetine). Summary of Product Characteristics. European Medicines Agency [updated 2021-12-21, cited 2022-02-21]
- Nationella riktlinjer för vård vid depression och ångestsyndrom 2021. Socialstyrelsen [www]. Socialstyrelsen. [updated 2021-04-01, cited 2021-05-14].
- LeGates TA, Kvarta MD, Thompson SM. Sex differences in antidepressant efficacy. Neuropsychopharmacology. 2019;44(1):140-154.
- Sramek JJ, Murphy MF, Cutler NR. Sex differences in the psychopharmacological treatment of depression. Dialogues Clin Neurosci. 2016;18(4):447-457.
- Kerber CS, Dyck MJ, Culp KR, Buckwalter K. Antidepressant treatment of depression in rural nursing home residents. Issues Ment Health Nurs. 2008;29(9):959-73.
- Labaka A, Goñi-Balentziaga O, Lebeña A, Pérez-Tejada J. Biological Sex Differences in Depression: A Systematic Review. Biol Res Nurs. 2018;20(4):383-392.
- Jalnapurkar I, Allen M, Pigott T. Sex Differences in Anxiety Disorders: A Review. J Psychiatr Depress Anxiety. 2018;4(1):2-9.
- Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the UK. Diabetes Care. 2011;34(10):2220-4.
- Tianmei S, Knadler MP, Lim MT, Yeo KP, Teng L, Liang S et al. Pharmacokinetics and tolerability of duloxetine following oral administration to healthy Chinese subjects. Clin Pharmacokinet. 2007;46(9):767-75.
- Lobo ED, Quinlan T, O'Brien L, Knadler MP, Heathman M. Population pharmacokinetics of orally administered duloxetine in patients: implications for dosing recommendation. Clin Pharmacokinet. 2009;48(3):189-97.
- Lobo ED, Quinlan T, Prakash A. Pharmacokinetics of orally administered duloxetine in children and adolescents with major depressive disorder. Clin Pharmacokinet. 2014;53(8):731-40.
- Kornstein SG, Wohlreich MM, Mallinckrodt CH, Watkin JG, Stewart DE. Duloxetine efficacy for major depressive disorder in male vs female patients: data from 7 randomized, double-blind, placebo-controlled trials. J Clin Psychiatry. 2006;67(5):761-70.
- Howland RH, Wilson MG, Kornstein SG, Clayton AH, Trivedi MH, Wohlreich MM et al. Factors predicting reduced antidepressant response: experience with the SNRI duloxetine in patients with major depression. Ann Clin Psychiatry. 2008;20(4):209-18.
- Wohlreich MM, Wiltse CG, Desaiah D, Ye W, Robinson RL, Kroenke K et al. Duloxetine in practice-based clinical settings: assessing effects on the emotional and physical symptoms of depression in an open-label, multicenter study. Prim Care Companion J Clin Psychiatry. 2007;9(4):271-9.
- Mallinckrodt CH, Watkin JG, Liu C, Wohlreich MM, Raskin J. Duloxetine in the treatment of Major Depressive Disorder: a comparison of efficacy in patients with and without melancholic features. BMC Psychiatry. 2005;5:1.
- Marchettini P, Wilhelm S, Petto H, Tesfaye S, Tölle T, Bouhassira D et al. Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy?. Eur J Pain. 2016;20(3):472-82.
- Ziegler D, Pritchett YL, Wang F, Desaiah D, Robinson MJ, Hall JA et al. Impact of disease characteristics on the efficacy of duloxetine in diabetic peripheral neuropathic pain. Diabetes Care. 2007;30(3):664-9.
- Velasco R, Besora S, Argyriou AA, Santos C, Sala R, Izquierdo C et al. Duloxetine against symptomatic chemotherapy-induced peripheral neurotoxicity in cancer survivors: a real world, open-label experience. Anticancer Drugs. 2021;32(1):88-94.
- Arnold LM. Duloxetine and other antidepressants in the treatment of patients with fibromyalgia. Pain Med. 2007;8 Suppl 2:S63-74.
- Arnold LM, Lu Y, Crofford LJ, Wohlreich M, Detke MJ, Iyengar S et al. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum. 2004;50(9):2974-84.
- Brunton S, Wang F, Edwards SB, Crucitti AS, Ossanna MJ, Walker DJ et al. Profile of adverse events with duloxetine treatment: a pooled analysis of placebo-controlled studies. Drug Saf. 2010;33(5):393-407.
- Stewart DE, Wohlreich MM, Mallinckrodt CH, Watkin JG, Kornstein SG. Duloxetine in the treatment of major depressive disorder: comparisons of safety and tolerability in male and female patients. J Affect Disord. 2006;94(1):183-9.
- Delgado PL, Brannan SK, Mallinckrodt CH, Tran PV, McNamara RK, Wang F et al. Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. J Clin Psychiatry. 2005;66(6):686-92.
- Montejo AL, Perahia DG, Spann ME, Wang F, Walker DJ, Yang CR et al. Sexual function during long-term duloxetine treatment in patients with recurrent major depressive disorder. J Sex Med. 2011;8(3):773-82.
- Revol R, Rault C, Polard E, Bellet F, Guy C. [Hyponatremia associated with SSRI/NRSI: Descriptive and comparative epidemiological study of the incidence rates of the notified cases from the data of the French National Pharmacovigilance Database and the French National Health Insurance]. Encephale. 2018;44(3):291-296.
- Mohan S, Gu S, Parikh A, Radhakrishnan J. Prevalence of hyponatremia and association with mortality: results from NHANES. Am J Med. 2013;126(12):1127-37e1.
- Forns J, Pottegård A, Reinders T, Poblador-Plou B, Morros R, Brandt L et al. Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: Incidence and comorbidities of antidepressant initiators. J Affect Disord. 2019;249:242-252.
- Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2021 [cited 2022-03-15.]
- Nationella riktlinjer för vård vid depression och ångestsyndrom 2021. Socialstyrelsen [www]. Socialstyrelsen. [updated 2021-04-01, cited 2021-05-14].
- LeGates TA, Kvarta MD, Thompson SM. Sex differences in antidepressant efficacy. Neuropsychopharmacology. 2019;44(1):140-154.
- Sramek JJ, Murphy MF, Cutler NR. Sex differences in the psychopharmacological treatment of depression. Dialogues Clin Neurosci. 2016;18(4):447-457.
- Kerber CS, Dyck MJ, Culp KR, Buckwalter K. Antidepressant treatment of depression in rural nursing home residents. Issues Ment Health Nurs. 2008;29(9):959-73.
- Labaka A, Goñi-Balentziaga O, Lebeña A, Pérez-Tejada J. Biological Sex Differences in Depression: A Systematic Review. Biol Res Nurs. 2018;20(4):383-392.
- Jalnapurkar I, Allen M, Pigott T. Sex Differences in Anxiety Disorders: A Review. J Psychiatr Depress Anxiety. 2018;4(1):2-9.
Uppdaterat
Litteratursökningsdatum: 2/21/2022
Litteratursökningsdatum: 2/21/2022