Kloxacillin
Kloxacillin
Klass : B
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Produkter
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Cloxacillin, Cloxacillin AB Unimedic Vial Mate, Cloxacillin Navamedic,......
Cloxacillin, Cloxacillin AB Unimedic Vial Mate, Cloxacillin Navamedic, Cloxacillin Stragen, Cloxacillin Vital Pharma Nordic, EkvacillinATC-koder
J01CF02
J01CF02Substanser
kloxacillin, kloxacillinnatrium (monohydrat)
kloxacillin, kloxacillinnatrium (monohydrat)Sammanfattning
Det saknas publicerade placebokontrollerade kliniska studier om skillnader mellan könen avseende effekt och säkerhet av kloxacillin. Farmakokinetiskt finns dock ingen påvisad könsskillnad.
Det saknas publicerade placebokontrollerade kliniska studier om skillnader mellan könen avseende effekt och säkerhet av kloxacillin. Farmakokinetiskt finns dock ingen påvisad könsskillnad.Background
Pharmacokinetics and dosing
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The only pharmacokinetic study with a clinically relevant sex difference analysis found was in patients undergoing hip or knee replacement. Men and women (14 and 24, respectively) received the same dose, cloxacillin 1 g i.v., but if corrected for body surface area, women received a 15% higher dose than men. When adjusted for body surface area, no differences in pharmacokinetic parameters were observed [1].
Effects
No studies with an analysis of clinically relevant sex differences of the effect of cloxacillin have been found, except in comparison with other antibacterial agents.
The influence of antibiotics on the incidence of recurrence of pilonidal sinus was evaluated in a prospective study and a subsequent randomized multicenter study (137 men, 60 women). Patients in the prospective group received cloxacillin 2 g i.v. before operation and 300 mg after followed by 600 mg daily for 6 days. Patients in the other group were randomized to either cefoxitin 2 g i.v. before operation or no prophylaxis. The authors report that neither the patients’ sex nor......
Försäljning på recept
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Läkemedel innehållande kloxacillin (ATC-kod J01CF02) används huvudsakligen på sjukhus och därför saknas könsspecifika användningsdata [5].
Referenser
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Vinge E, Nergelius G, Nilsson LG, Lidgren L. Pharmacokinetics of cloxacillin in patients undergoing hip or knee replacement. Eur J Clin Pharmacol. 1997;52:407-11.
Søndenaa K, Diab R, Nesvik I, Gullaksen FP, Kristiansen RM, Saebø A et al. Influence of failure of primary wound healing on subsequent recurrence of pilonidal sinus combined prospective study and randomised controlled trial. Eur J Surg. 2002;168:614-8.
Korinek AM, Golmard JL, Elcheick A, Bismuth R, van Effenterre R, Coriat P et al. Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients. Br J Neurosurg. 2005;19:155-62.
Korinek AM, Baugnon T, Golmard JL, van Effenterre R, Coriat P, Puybasset L. Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgery. 2006;59:126-33; discussion 126-33.
Concise. Stockholm: eHälsomyndigheten. 2015 [cited 2016-10-20.]
- Vinge E, Nergelius G, Nilsson LG, Lidgren L. Pharmacokinetics of cloxacillin in patients undergoing hip or knee replacement. Eur J Clin Pharmacol. 1997;52:407-11.
- Søndenaa K, Diab R, Nesvik I, Gullaksen FP, Kristiansen RM, Saebø A et al. Influence of failure of primary wound healing on subsequent recurrence of pilonidal sinus combined prospective study and randomised controlled trial. Eur J Surg. 2002;168:614-8.
- Korinek AM, Golmard JL, Elcheick A, Bismuth R, van Effenterre R, Coriat P et al. Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients. Br J Neurosurg. 2005;19:155-62.
- Korinek AM, Baugnon T, Golmard JL, van Effenterre R, Coriat P, Puybasset L. Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgery. 2006;59:126-33; discussion 126-33.
- Concise. Stockholm: eHälsomyndigheten. 2015 [cited 2016-10-20.]
Uppdaterat
Litteratursökningsdatum: 10/17/2016
Litteratursökningsdatum: 10/17/2016Se även
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