Ciprofloxacin
Ciprofloxacin
Klass : A
Visa all info
Skriv ut
Kontakta oss
Produkter
Visa alla produkter
Ciflox, Ciprofloxacin Accord, Ciprofloxacin Actavis, Ciprofloxacin Ari......
Ciflox, Ciprofloxacin Accord, Ciprofloxacin Actavis, Ciprofloxacin Aristo, Ciprofloxacin Arrow, Ciprofloxacin BMM Pharma, Ciprofloxacin Bluefish, Ciprofloxacin Ebb, Ciprofloxacin Fresenius Kabi, Ciprofloxacin Hexal, Ciprofloxacin Hospira, Ciprofloxacin Kabi, Ciprofloxacin Krka, Ciprofloxacin MDS, Ciprofloxacin Navamedic, Ciprofloxacin Orion, Ciprofloxacin Ranbaxy, Ciprofloxacin STADA, Ciprofloxacin SUN, Ciprofloxacin Sandoz, Ciprofloxacin Viatris, CiproxinATC-koder
J01MA02
J01MA02Substanser
Visa alla substanser
ciprofloxacin, ciprofloxacinhydroklorid (monohydrat), ciprofloxacinhyd......
ciprofloxacin, ciprofloxacinhydroklorid (monohydrat), ciprofloxacinhydroklorid (vattenfri), ciprofloxacinlaktat, ciprofloxacinvätesulfatSammanfattning
Ciprofloxacin är associerat med QT-förlängning på EKG och därmed risk för allvarlig rytmrubbning av typen Torsade de Pointes kammartakykardi. Könsskillnad har inte påvisats för just ciprofloxacin men allmänt är det fler kvinnor än män som får läkemedelsinducerade rytmrubbningen av typen Torsade de Pointes. Farmakokinetiska studier visar att kvinnor får högre koncentration ciprofloxacin än män vid intag av samma dos. I vissa av dessa studier försvinner denna skillnad om doserna viktjusteras. For kinoloner korrelerar AUC/MIC bäst till terapeutisk respons.
Ciprofloxacin är associerat med QT-förlängning på EKG och därmed risk för allvarlig rytmrubbning av typen Torsade de Pointes kammartakykardi. Könsskillnad har inte påvisats för just ciprofloxacin men allmänt är det fler kvinnor än män som får läkemedelsinducerade rytmrubbningen av typen Torsade de Pointes. Farmakokinetiska studier visar att kvinnor får högre koncentration ciprofloxacin än män vid intag av samma dos. I vissa av dessa studier försvinner denna skillnad om doserna viktjusteras. For kinoloner korrelerar AUC/MIC bäst till terapeutisk respons.Background
Pharmacokinetics and dosing
Visa hela bakgrundstexten
Studies on sex differences in ciprofloxacin pharmacokinetics show conflicting results. In a Dutch prospective observational cohort study ciprofloxacin pharmacokinetics was studied in critically ill patients in intensive care (24 men, 8 women). Following intravenous administration of 400 mg ciprofloxacin, exposure was higher in women. The difference in AUC between men and women was not due to variation in body weight or differences in bioavailability and thus a lower clearance in women was suggested [2]. Similar conclusions were drawn in a study in healthy volunteers (8 men, 7 women) where women were found to have increased exposure and slower clearance [3]. Sex differences in ciprofloxacin pharmacokinetics were also investigated in a study where healthy volunteers (12 men, 12 women) received a single oral dose of 100 mg ciprofloxacin. The statistical methods were complex but the results of the study demonstrated that women had higher exposure to ciprofloxacin even after adjustment for body weight [4].
In contrast, results from a multiple-dose pharmacoki......
Försäljning på recept
Visa hela försäljning på recept
Fler män än kvinnor hämtade ut läkemedel innehållande ciprofloxacin (ATC-kod J01MA02) på recept i Sverige år 2021, totalt 66 921 män och 48 066 kvinnor. Det motsvarar 13 respektive 9 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 75 år och äldre hos båda könen. I genomsnitt var läkemedel innehållande ciprofloxacin 7,8 gånger vanligare hos män [17].
Referenser
Visa referenser
Rocha JL, Tuon FF, Johnson JR. Sex, drugs, bugs, and age: rational selection of empirical therapy for outpatient urinary tract infection in an era of extensive antimicrobial resistance. Braz J Infect Dis. 2012;16:115-21.
van Zanten AR, Polderman KH, van Geijlswijk IM, van der Meer GY, Schouten MA, Girbes AR. Ciprofloxacin pharmacokinetics in critically ill patients: a prospective cohort study. J Crit Care. 2008;23:422-30.
Overholser BR, Kays MB, Forrest A, Sowinski KM. Sex-related differences in the pharmacokinetics of oral ciprofloxacin. J Clin Pharmacol. 2004;44:1012-22.
Konieczna L, Chmielewska A, Lamparczyk H. Influence of sex on the pharmacokinetics of ciprofloxacin and ofloxacin. Chemotherapy. 2006;52:111-21.
Höffler D, Dalhoff A, Gau W, Beermann D, Michl A. Dose- and sex-independent disposition of ciprofloxacin. Eur J Clin Microbiol. 1984;3:363-6.
Gallicano K, Sahai J. Lack of gender effect on ciprofloxacin pharmacokinetics in humans. Br J Clin Pharmacol. 1996;42:632-4.
Shah A, Lettieri J, Nix D, Wilton J, Heller AH. Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects. Antimicrob Agents Chemother. 1995;39:1003-6.
Ciproxin (ciprofloxacin). Summary of Product Characteristics. Swedish Medical Products Agency (MPA) [updated 2022-02-01, cited 2022-06-16]
Gunderson BW, Ross GH, Ibrahim KH, Rotschafer JC. What do we really know about antibiotic pharmacodynamics?. Pharmacotherapy. 2001;21:302S-318S.
den Heijer CD, Donker GA, Maes J, Stobberingh EE. Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval. J Antimicrob Chemother. 2010;65:2128-33.
den Heijer CD, Penders J, Donker GA, Bruggeman CA, Stobberingh EE. The importance of gender-stratified antibiotic resistance surveillance of unselected uropathogens: a Dutch Nationwide Extramural Surveillance study. PLoS One. 2013;8:e60497.
McGregor JC, Elman MR, Bearden DT, Smith DH. Sex- and age-specific trends in antibiotic resistance patterns of Escherichia coli urinary isolates from outpatients. BMC Fam Pract. 2013;14:25.
Linhares I, Raposo T, Rodrigues A, Almeida A. Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000-2009). BMC Infect Dis. 2013;13:19.
Mostafavi SN, Rostami S, Rezaee Nejad Y, Ataei B, Mobasherizadeh S, Cheraghi A et al. Antimicrobial Resistance in Hospitalized Patients with Community Acquired Urinary Tract Infection in Isfahan, Iran. Arch Iran Med. 2021;24(3):187-192.
Briasoulis A, Agarwal V, Pierce WJ. QT prolongation and torsade de pointes induced by fluoroquinolones: infrequent side effects from commonly used medications. Cardiology. 2011;120(2):103-10.
Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013-22.
Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2021 [cited 2022-03-15.]
- Rocha JL, Tuon FF, Johnson JR. Sex, drugs, bugs, and age: rational selection of empirical therapy for outpatient urinary tract infection in an era of extensive antimicrobial resistance. Braz J Infect Dis. 2012;16:115-21.
- van Zanten AR, Polderman KH, van Geijlswijk IM, van der Meer GY, Schouten MA, Girbes AR. Ciprofloxacin pharmacokinetics in critically ill patients: a prospective cohort study. J Crit Care. 2008;23:422-30.
- Overholser BR, Kays MB, Forrest A, Sowinski KM. Sex-related differences in the pharmacokinetics of oral ciprofloxacin. J Clin Pharmacol. 2004;44:1012-22.
- Konieczna L, Chmielewska A, Lamparczyk H. Influence of sex on the pharmacokinetics of ciprofloxacin and ofloxacin. Chemotherapy. 2006;52:111-21.
- Höffler D, Dalhoff A, Gau W, Beermann D, Michl A. Dose- and sex-independent disposition of ciprofloxacin. Eur J Clin Microbiol. 1984;3:363-6.
- Gallicano K, Sahai J. Lack of gender effect on ciprofloxacin pharmacokinetics in humans. Br J Clin Pharmacol. 1996;42:632-4.
- Shah A, Lettieri J, Nix D, Wilton J, Heller AH. Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects. Antimicrob Agents Chemother. 1995;39:1003-6.
- Ciproxin (ciprofloxacin). Summary of Product Characteristics. Swedish Medical Products Agency (MPA) [updated 2022-02-01, cited 2022-06-16]
- Gunderson BW, Ross GH, Ibrahim KH, Rotschafer JC. What do we really know about antibiotic pharmacodynamics?. Pharmacotherapy. 2001;21:302S-318S.
- den Heijer CD, Donker GA, Maes J, Stobberingh EE. Antibiotic susceptibility of unselected uropathogenic Escherichia coli from female Dutch general practice patients: a comparison of two surveys with a 5 year interval. J Antimicrob Chemother. 2010;65:2128-33.
- den Heijer CD, Penders J, Donker GA, Bruggeman CA, Stobberingh EE. The importance of gender-stratified antibiotic resistance surveillance of unselected uropathogens: a Dutch Nationwide Extramural Surveillance study. PLoS One. 2013;8:e60497.
- McGregor JC, Elman MR, Bearden DT, Smith DH. Sex- and age-specific trends in antibiotic resistance patterns of Escherichia coli urinary isolates from outpatients. BMC Fam Pract. 2013;14:25.
- Linhares I, Raposo T, Rodrigues A, Almeida A. Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000-2009). BMC Infect Dis. 2013;13:19.
- Mostafavi SN, Rostami S, Rezaee Nejad Y, Ataei B, Mobasherizadeh S, Cheraghi A et al. Antimicrobial Resistance in Hospitalized Patients with Community Acquired Urinary Tract Infection in Isfahan, Iran. Arch Iran Med. 2021;24(3):187-192.
- Briasoulis A, Agarwal V, Pierce WJ. QT prolongation and torsade de pointes induced by fluoroquinolones: infrequent side effects from commonly used medications. Cardiology. 2011;120(2):103-10.
- Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013-22.
- Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2021 [cited 2022-03-15.]
Uppdaterat
Litteratursökningsdatum: 6/16/2022
Litteratursökningsdatum: 6/16/2022Fasstexter
Visa fasstexter