Ceftazidim
Ceftazidim
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Ceftazidim Actavis, Ceftazidim Dr. Eberth, Ceftazidim Fresenius Kabi, ......
Ceftazidim Actavis, Ceftazidim Dr. Eberth, Ceftazidim Fresenius Kabi, Ceftazidim Hikma, Ceftazidim Sandoz, Ceftazidima Hikma, Ceftazidime, Ceftazidime for Injection BP, Fortam, FortumATC-koder
J01DD02
J01DD02Substanser
ceftazidim, ceftazidimpentahydrat
ceftazidim, ceftazidimpentahydratSammanfattning
Hos patienter med samhällsförvärvad pneumoni har effekten av ceftazidim visats vara likvärdig hos kvinnor och män.
Hos patienter med samhällsförvärvad pneumoni har effekten av ceftazidim visats vara likvärdig hos kvinnor och män.Background
Pharmacokinetics and dosing
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The pharmacokinetics of ceftazidime was assessed in healthy volunteers (12 men, 12 women) receiving 1 g ceftazidime as bolus i.v. injection. Volume of distribution was 17% lower in women. Eight men and eight women also received 1 g ceftazidime i.m. injection. Compared to men, women had 38% higher volume of distribution, 25% lower AUC, higher Cmax and longer Tmax [2]. Also a study in burn patients found that the volume of distribution was higher in women (20%) [3].
In an Ethiopian study assessing appropriate dosage adjustments were made in hospitalized patients with renal impairment (40 men, 33 women), Multivariate analysis showed that there were no difference between men and women in the proportion of appropriately adjusted prescription entries per patient [4].
During pregnancy, renal clearance of ceftazidime has been shown to be higher, 39% during first trimester and 65 % during third trimester, than post-partum. The authors suggest that the dosage of ceftazidime should be increased in pregnancy by approximately 40% [5].
Effects
The clinical and bact......
Försäljning på recept
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Läkemedel innehållande ceftazidim (ATC-kod J01DD02) används huvudsakligen på sjukhus och därför saknas könsspecifika användningsdata [6].
Referenser
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Finch RG, Pemberton K, Gildon KM. Pneumonia: the impact of risk factors on the outcome of treatment with meropenem and ceftazidime. J Chemother. 1998;10:35-46.
Sommers DK, Walters L, Van Wyk M, Harding SM, Paton AM, Ayrton J. Pharmacokinetics of ceftazidime in male and female volunteers. Antimicrob Agents Chemother. 1983;23:892-6.
Conil JM, Georges B, Lavit M, Laguerre J, Samii K, Houin G et al. A population pharmacokinetic approach to ceftazidime use in burn patients: influence of glomerular filtration, gender and mechanical ventilation. Br J Clin Pharmacol. 2007;64:27-35.
Getachew H, Tadesse Y, Shibeshi W. Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. BMC Nephrol. 2015;16:158.
Nathorst-Böös J, Philipson A, Hedman A, Arvisson A. Renal elimination of ceftazidime during pregnancy. Am J Obstet Gynecol. 1995;172:163-6.
Concise. Stockholm: eHälsomyndigheten. 2015 [cited 2016-08-22.]
- Finch RG, Pemberton K, Gildon KM. Pneumonia: the impact of risk factors on the outcome of treatment with meropenem and ceftazidime. J Chemother. 1998;10:35-46.
- Sommers DK, Walters L, Van Wyk M, Harding SM, Paton AM, Ayrton J. Pharmacokinetics of ceftazidime in male and female volunteers. Antimicrob Agents Chemother. 1983;23:892-6.
- Conil JM, Georges B, Lavit M, Laguerre J, Samii K, Houin G et al. A population pharmacokinetic approach to ceftazidime use in burn patients: influence of glomerular filtration, gender and mechanical ventilation. Br J Clin Pharmacol. 2007;64:27-35.
- Getachew H, Tadesse Y, Shibeshi W. Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. BMC Nephrol. 2015;16:158.
- Nathorst-Böös J, Philipson A, Hedman A, Arvisson A. Renal elimination of ceftazidime during pregnancy. Am J Obstet Gynecol. 1995;172:163-6.
- Concise. Stockholm: eHälsomyndigheten. 2015 [cited 2016-08-22.]
Uppdaterat
Litteratursökningsdatum: 8/16/2016
Litteratursökningsdatum: 8/16/2016