Budesonid – för inhalation
Budesonid – för inhalation
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Assieme Turbuhaler, Assieme forte Turbuhaler, Assieme m......
Assieme Turbuhaler, Assieme forte Turbuhaler, Assieme mite Turbuhaler, Budesonid 2care4, Budesonid Arrow, Budesonid Orifarm, Budesonid Teva, Budesonide STADA, Budesonide Teva Pharma, Bufomix Easyhaler, DuoResp Spiromax, Giona Easyhaler, Novopulmon Novolizer, Pulmicort, Pulmicort Turbuhaler, Rilast Turbuhaler, Rilast forte Turbuhaler, Sinestic Turbuhaler, Sinestic forte Turbuhaler, Symbicort, Symbicort Turbuhaler, Symbicort Turbuhaler, Symbicort forte Turbuhaler, Symbicort mite Turbuhaler, Trixeo AerosphereATC-koder
R03AK07, R03AL11, R03BA02
R03AK07, R03AL11, R03BA02Substanser
budesonid
budesonidSammanfattning
En stor kohortstudie har inte visat några könsskillnader i effekt av olika astmaläkemedel inklusive budesonid. Man fann att individer över 30 år oavsett kön erhöll sämre behandlingseffekt. En mindre studie fann generellt sämre inhalationsteknik hos kvinnor vilket gav lägre effektiv dos.
En stor kohortstudie har inte visat några könsskillnader i effekt av olika astmaläkemedel inklusive budesonid. Man fann att individer över 30 år oavsett kön erhöll sämre behandlingseffekt. En mindre studie fann generellt sämre inhalationsteknik hos kvinnor vilket gav lägre effektiv dos.Background
Some studies suggest that there are sex differences in expression and diagnosing of asthma, and it has been discussed whether women are under-treated for respiratory diseases or not [5, 6]. Visa hela bakgrundstexten
Pharmacokinetics and dosing
According to population pharmacokinetic studies conducted by the manufacturer, no differences in pharmacokinetics have been identified due to sex or age for inhalation of budesonide [7]. Persons with lower body weight may have higher bioavailability of budesonide [8].
Effects
A large cohort study (520 men, 680 women) investigated the impact of sex and age on response to asthma therapy (including salbutamol, salmeterol, inhaled budesonide, zafirlukast, montelukast, beclomethasone and inhaled corticosteroids). There was no difference between men and women in treatment failure for any individual therapy. Individuals aged 30 years and older were more likely to have treatment failure but the risk was similar for men and women [9].
Results from controlled clinical trials conducted by the manufacturer showed similar symptom reduction to budesonide suspension in both boys a......
Försäljning på recept
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Fler kvinnor än män hämtade ut budesonid för inhalation (ATC-kod R03BA02) på recept i Sverige år 2016, totalt 150 512 kvinnor och 107 519 män. Det motsvarar 31 respektive 22 personer per tusen invånare. I åldersgruppen 0-14 år var budesonid för inhalation i genomsnitt 1,5 gånger vanligare hos pojkar och i åldersgruppen 15 år och äldre i genomsnitt 1,5 gånger vanligare hos kvinnor [12].
Referenser
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Goodman DE, Israel E, Rosenberg M, Johnston R, Weiss ST, Drazen JM. The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med. 1994;150:1256-61.
Osborne ML, Vollmer WM, Linton KL, Buist AS. Characteristics of patients with asthma within a large HMO: a comparison by age and gender. Am J Respir Crit Care Med. 1998;157:123-8.
Prescott E, Lange P, Vestbo J. Effect of gender on hospital admissions for asthma and prevalence of self-reported asthma: a prospective study based on a sample of the general population Copenhagen City Heart Study Group. Thorax. 1997;52:287-9.
Ng TP, Niti M, Tan WC. Trends and ethnic differences in asthma hospitalization rates in Singapore, 1991 to 1998. Ann Allergy Asthma Immunol. 2003;90:51-5.
Dales RE, Mehdizadeh A, Aaron SD, Vandemheen KL, Clinch J. Sex differences in the clinical presentation and management of airflow obstruction. Eur Respir J. 2006;28:319-22.
Tantisira KG, Colvin R, Tonascia J, Strunk RC, Weiss ST, Fuhlbrigge AL et al. Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med. 2008;178:325-31.
Budesonid inhalation (budesonide) suspension. DailyMed [www]. US National Library of Medicine. [updated 2016-12-07, cited 2017-03-02].
Food and Drug Administration (FDA). Clinical Pharmacology and Biopharmaceutics Review - Symbicort (budesonide/formoterol) Inhalation Aerosol. Food and Drug Administration [www]. [updated 2008-10-30, cited 2017-03-02].
Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E et al. Impact of Age and Sex on Response to Asthma Therapy. Am J Respir Crit Care Med. 2015;192:551-8.
Ip M, Lam K, Yam L, Kung A, Ng M. Decreased bone mineral density in premenopausal asthma patients receiving long-term inhaled steroids. Chest. 1994;105:1722-7.
Ota K, Hasegawa T, Koya T, Sakagami T, Sekikawa T, Toyabe S et al. Analysis of inhaled corticosteroid selection in patients with bronchial asthma using a questionnaire survey--effects of age, gender, and disease severity. Allergol Int. 2009;58:365-71.
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2016 [cited 2017-03-23.]
- Goodman DE, Israel E, Rosenberg M, Johnston R, Weiss ST, Drazen JM. The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med. 1994;150:1256-61.
- Osborne ML, Vollmer WM, Linton KL, Buist AS. Characteristics of patients with asthma within a large HMO: a comparison by age and gender. Am J Respir Crit Care Med. 1998;157:123-8.
- Prescott E, Lange P, Vestbo J. Effect of gender on hospital admissions for asthma and prevalence of self-reported asthma: a prospective study based on a sample of the general population Copenhagen City Heart Study Group. Thorax. 1997;52:287-9.
- Ng TP, Niti M, Tan WC. Trends and ethnic differences in asthma hospitalization rates in Singapore, 1991 to 1998. Ann Allergy Asthma Immunol. 2003;90:51-5.
- Dales RE, Mehdizadeh A, Aaron SD, Vandemheen KL, Clinch J. Sex differences in the clinical presentation and management of airflow obstruction. Eur Respir J. 2006;28:319-22.
- Tantisira KG, Colvin R, Tonascia J, Strunk RC, Weiss ST, Fuhlbrigge AL et al. Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med. 2008;178:325-31.
- Budesonid inhalation (budesonide) suspension. DailyMed [www]. US National Library of Medicine. [updated 2016-12-07, cited 2017-03-02].
- Food and Drug Administration (FDA). Clinical Pharmacology and Biopharmaceutics Review - Symbicort (budesonide/formoterol) Inhalation Aerosol. Food and Drug Administration [www]. [updated 2008-10-30, cited 2017-03-02].
- Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E et al. Impact of Age and Sex on Response to Asthma Therapy. Am J Respir Crit Care Med. 2015;192:551-8.
- Ip M, Lam K, Yam L, Kung A, Ng M. Decreased bone mineral density in premenopausal asthma patients receiving long-term inhaled steroids. Chest. 1994;105:1722-7.
- Ota K, Hasegawa T, Koya T, Sakagami T, Sekikawa T, Toyabe S et al. Analysis of inhaled corticosteroid selection in patients with bronchial asthma using a questionnaire survey--effects of age, gender, and disease severity. Allergol Int. 2009;58:365-71.
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2016 [cited 2017-03-23.]
Uppdaterat
Litteratursökningsdatum 3/2/2017
Litteratursökningsdatum 3/2/2017