Brinzolamid
Brinzolamid
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Produkter
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AZARGA, AZOPT, Brinzolamid Ebb, Brinzolamid Stada, Brin......
AZARGA, AZOPT, Brinzolamid Ebb, Brinzolamid Stada, Brinzolamide 2care4, Brinzolamide Accord, Brinzolamide Orifarm, Brinzolamide Sandoz, Brinzolamide/Timolol Abacus Medicine, Brinzolamide/Timolol Accord, Brinzolamide/Timolol STADA, SIMBRINZAATC-koder
S01EC04, S01EC54, S01ED51
S01EC04, S01EC54, S01ED51Substanser
brinzolamid
brinzolamidSammanfattning
En studie visade att tillägg av brinzolamid till timololbehandling resulterade i liknande intraockulär trycksänkning hos kvinnor och män.
En studie visade att tillägg av brinzolamid till timololbehandling resulterade i liknande intraockulär trycksänkning hos kvinnor och män.Background
Pharmacokinetics and dosing
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No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of brinzolamide eyedrops have been found.
Effects
A prospective open-label study during six months where 119 glaucoma patients (56 men, 63 women) were switched from timolol to brinzolamide /timolol fixed combination showed that the median intraocular pressure decreased from 20 to 16 mmHg similarly in men and women [10].
Adverse effects
According to The European Medicines Agency, Summary of Product Characteristics (SmPC) of Azarga and Azopt, an uncommon side effect could be male sexual difficulty (may affect up to 1 in 100 people) [11, 12].
Reproductive health issues
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Other information
In a population-based survey study including a medical examination in 4744 Australians, 2.3% were previously diagnosed with ocular hypertension or open angle glaucoma (52 male, 56 female). The proportion reporting a history of glaucoma surgery or treatment wit......
Försäljning på recept
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Fler kvinnor än män hämtade ut ögondroppar innehållande brinzolamid (ATC-kod S01EC04) på recept i Sverige år 2015, totalt 13 066 kvinnor och 10 494 män. Det motsvarar 2,7 respektive 2,2 personer per tusen invånare. Andelen som hämtat ut läkemedel ökade med stigande ålder hos båda könen [13]. # Kombinationsprodukter Fler kvinnor än män hämtade ut ögondroppar innehållande timolol i kombination (ATC-kod S01ED51) på recept i Sverige år 2015, totalt 38 434 kvinnor och 33 818 män. Det motsvarar 7,9 respektive 6,9 personer per tusen invånare. Andelen som hämtat ut läkemedel ökade med stigande ålder hos båda könen [13]. ATC-koden innehåller timololkombinationer med bimatoprost, brinzolamid, brimonidin, dorzolamid, latanoprost, pilokarpin, travoprost, tafluprost. Kombinationen timolol/brinzolamid utgör 13 % av den totala försäljningen i denna ATC-kod [14]. Något fler kvinnor än män hämtade ut ögondroppar innehållande kombination av brimonidin och brinzolamid (ATC-kod S01EC54) på recept i Sverige år 2015, totalt 2 483 kvinnor och 2 073 män. Det motsvarar 0,5 respektive 0,4 personer per tusen invånare. Andelen som hämtat ut läkemedel ökade med stigande ålder hos båda könen [13].
Referenser
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Weih LM, Van Newkirk M, McCarty CA, Taylor HR. Patterns of glaucoma medication use in urban and rural Victoria. Aust N Z J Ophthalmol. 1998;26 Suppl 1:S12-5.
Nordstrom BL, Friedman DS, Mozaffari E, Quigley HA, Walker AM. Persistence and adherence with topical glaucoma therapy. Am J Ophthalmol. 2005;140:598-606.
Drance S, Anderson DR, Schulzer M, Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001;131:699-708.
Alsbirk PH. Early detection of primary angle-closure glaucoma Limbal and axial chamber depth screening in a high risk population (Greenland Eskimos). Acta Ophthalmol (Copenh). 1988;66:556-64.
Alsbirk PH. Limbal and axial chamber depth variations A population study in Eskimos. Acta Ophthalmol (Copenh). 1986;64:593-600.
Higginbotham EJ. Does sex matter in glaucoma?. Arch Ophthalmol. 2004;122:374-5.
Kang JH, Wiggs JL, Rosner BA, Hankinson SE, Abdrabou W, Fan BJ et al. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Invest Ophthalmol Vis Sci. 2010;51:971-9.
Vajaranant TS, Nayak S, Wilensky JT, Joslin CE. Gender and glaucoma: what we know and what we need to know. Curr Opin Ophthalmol. 2010;21:91-9.
Singh D, Coote MA, O'Hare F, Walland MJ, Ghosh S, Xie J et al. Topical prostaglandin analogues do not affect selective laser trabeculoplasty outcomes. Eye (Lond). 2009;23:2194-9.
Rossi GC, Tinelli C, Pasinetti GM, Fusetti M, Pallavicini C, Stringa M et al. Signs and symptoms of ocular surface status in glaucoma patients switched from timolol 05% to brinzolamide 1%/timolol 05% fixed combination: a 6-month efficacy and tolerability, multicenter, open-label prospective study. Expert Opin Pharmacother. 2011;12:685-90.
AZARGA (brinzolamide / timolol). Summary of Product Characteristics. European Medicines Agency (EMA); 2008.
AZOPT (brinzolamide). Summary of Product Characteristics. European Medicines Agency (EMA); 2000.
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.]
Conicse. Stockholm: eHälsomyndigheten. 2015 [cited 2016-03-23.]
- Weih LM, Van Newkirk M, McCarty CA, Taylor HR. Patterns of glaucoma medication use in urban and rural Victoria. Aust N Z J Ophthalmol. 1998;26 Suppl 1:S12-5.
- Nordstrom BL, Friedman DS, Mozaffari E, Quigley HA, Walker AM. Persistence and adherence with topical glaucoma therapy. Am J Ophthalmol. 2005;140:598-606.
- Drance S, Anderson DR, Schulzer M, Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001;131:699-708.
- Alsbirk PH. Early detection of primary angle-closure glaucoma Limbal and axial chamber depth screening in a high risk population (Greenland Eskimos). Acta Ophthalmol (Copenh). 1988;66:556-64.
- Alsbirk PH. Limbal and axial chamber depth variations A population study in Eskimos. Acta Ophthalmol (Copenh). 1986;64:593-600.
- Higginbotham EJ. Does sex matter in glaucoma?. Arch Ophthalmol. 2004;122:374-5.
- Kang JH, Wiggs JL, Rosner BA, Hankinson SE, Abdrabou W, Fan BJ et al. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Invest Ophthalmol Vis Sci. 2010;51:971-9.
- Vajaranant TS, Nayak S, Wilensky JT, Joslin CE. Gender and glaucoma: what we know and what we need to know. Curr Opin Ophthalmol. 2010;21:91-9.
- Singh D, Coote MA, O'Hare F, Walland MJ, Ghosh S, Xie J et al. Topical prostaglandin analogues do not affect selective laser trabeculoplasty outcomes. Eye (Lond). 2009;23:2194-9.
- Rossi GC, Tinelli C, Pasinetti GM, Fusetti M, Pallavicini C, Stringa M et al. Signs and symptoms of ocular surface status in glaucoma patients switched from timolol 05% to brinzolamide 1%/timolol 05% fixed combination: a 6-month efficacy and tolerability, multicenter, open-label prospective study. Expert Opin Pharmacother. 2011;12:685-90.
- AZARGA (brinzolamide / timolol). Summary of Product Characteristics. European Medicines Agency (EMA); 2008.
- AZOPT (brinzolamide). Summary of Product Characteristics. European Medicines Agency (EMA); 2000.
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.]
- Conicse. Stockholm: eHälsomyndigheten. 2015 [cited 2016-03-23.]
Uppdaterat
Litteratursökningsdatum 12/2/2015
Litteratursökningsdatum 12/2/2015Se även
Timolol