Kolestyramin
Kolestyramin
Klass : A
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Produkter
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Colestyramin, Kolestyramin Alternova, Lipocol-Mertz, Quantalan, Quanta......
Colestyramin, Kolestyramin Alternova, Lipocol-Mertz, Quantalan, Quantalan zuckerfrei, Questran, Questran Light, Questran LocATC-koder
C10AC01
C10AC01Substanser
kolestyramin
kolestyraminSammanfattning
Den lipidsänkande effekten av kolestyramin hos patienter med hyperlipoproteinemi är likvärdig för kvinnor och män.
Den lipidsänkande effekten av kolestyramin hos patienter med hyperlipoproteinemi är likvärdig för kvinnor och män.Background
Pharmacokinetics and dosing
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No specific studies on relevant sex differences between men and women in pharmacokinetics or dosing of cholestyramine were found.
Effects
The lipid-lowering efficacy of cholestyramine 16 g/day in patients with hyperlipoproteinemia was analyzed in a randomized, double-blind, placebo-controlled study (29 men, 18 women). Despite that women had higher baseline cholesterol levels, the mean percentage fall in cholesterol levels induced by cholestyramine did not differ between men and women [1].
Cholestyramine therapy was compared to lovastatin therapy in patients with severe primary?? hypercholesterolemia in a randomized, single-blind, placebo-controlled study (170 men, 94 women). Men and women taking cholestyramine 12 g twice daily had a similar mean reduction in the levels of LDL cholesterol, while women treated with lovastatin 20-40 mg twice daily had larger mean reductions LDL levels than men [2].
No studies on sex differences in clinical outcomes such as morbidity and mortality were found.
Adverse effects
No specific studies on relevant sex differenc......
Försäljning på recept
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Fler kvinnor än män hämtade ut läkemedel innehållande kolestyramin (ATC-kod C10AC01) på recept i Sverige år 2022, totalt 6 634 kvinnor och 4 158 män. Det motsvarar 1,3 respektive 0,8 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 70 år och äldre hos båda könen. I genomsnitt var läkemedel innehållande kolestyramin 1,5 gånger vanligare hos kvinnor [3].
Referenser
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Levy RI, Fredrickson DS, Stone NJ, Bilheimer DW, Brown WV, Glueck CJ et al. Cholestyramine in type II hyperlipoproteinemia A double-blind trial. Ann Intern Med. 1973;79:51-8.
The Lovastatin Study Group. A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia The Lovastatin Study Group III. JAMA. 1988;260:359-66.
Eriksson M, Hådell K, Holme I, Walldius G, Kjellström T. Compliance with and efficacy of treatment with pravastatin and cholestyramine: a randomized study on lipid-lowering in primary care. J Intern Med. 1998;243:373-80.
Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2022 [cited 2023-03-02.]
- Levy RI, Fredrickson DS, Stone NJ, Bilheimer DW, Brown WV, Glueck CJ et al. Cholestyramine in type II hyperlipoproteinemia A double-blind trial. Ann Intern Med. 1973;79:51-8.
- The Lovastatin Study Group. A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia The Lovastatin Study Group III. JAMA. 1988;260:359-66.
- Eriksson M, Hådell K, Holme I, Walldius G, Kjellström T. Compliance with and efficacy of treatment with pravastatin and cholestyramine: a randomized study on lipid-lowering in primary care. J Intern Med. 1998;243:373-80.
- Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2022 [cited 2023-03-02.]
Uppdaterat
Litteratursökningsdatum: 6/13/2022
Litteratursökningsdatum: 6/13/2022