11/21/2024

Janusmed kön och genus

Janusmed kön och genus – Klozapin

Janusmed kön och genus är ett kunskapsstöd som tillhandahåller information om köns- och genusaspekter på läkemedelsbehandling. Kunskapsstödet är avsedd främst för hälso- och sjukvårdspersonal. Texterna är generella och ska inte ses som behandlingsriktlinjer. Det är alltid behandlande läkare som ansvarar för patientens medicinering.

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C C
C C

Klozapin

Klozapin

Klass : C

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  1. Leponex (klozapin). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2019-09-22, cited 2020-08-25]

  2. Krivoy A, Gaughran F, Weizman A, Breen G, MacCabe JH. Gene polymorphisms potentially related to the pharmacokinetics of clozapine: a systematic review. Int Clin Psychopharmacol. 2016;31(4):179-84.

  3. Eiermann B, Engel G, Johansson I, Zanger UM, Bertilsson L. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br J Clin Pharmacol. 1997;44(5):439-46.

  4. Albitar O, Harun SN, Zainal H, Ibrahim B, Sheikh Ghadzi SM. Population Pharmacokinetics of Clozapine: A Systematic Review. Biomed Res Int. 2020;2020:9872936.

  5. Mayerova M, Ustohal L, Jarkovsky J, Pivnicka J, Kasparek T, Ceskova E. Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations. Neuropsychiatr Dis Treat. 2018;14:1535-1543.

  6. Aichhorn W, Whitworth AB, Weiss EM, Marksteiner J. Second-generation antipsychotics: is there evidence for sex differences in pharmacokinetic and adverse effect profiles?. Drug Saf. 2006;29(7):587-98.

  7. Ng W, Uchida H, Ismail Z, Mamo DC, Rajji TK, Remington G et al. Clozapine exposure and the impact of smoking and gender: a population pharmacokinetic study. Ther Drug Monit. 2009;31(3):360-6.

  8. Rostami-Hodjegan A, Amin AM, Spencer EP, Lennard MS, Tucker GT, Flanagan RJ. Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients. J Clin Psychopharmacol. 2004;24(1):70-8.

  9. Janusmed Interactions. Stockholm: Region Stockholm. 2020 [updated 2020-08-19, cited 2020-08-26.]

  10. Stockley’s Drug Interactions. London: Royal Pharmaceutical Society. 2020 [updated 2020-08-11, cited 2020-08-26.]

  11. Usall J, Suarez D, Haro JM, SOHO Study Group. Gender differences in response to antipsychotic treatment in outpatients with schizophrenia. Psychiatry Res. 2007;153:225-31.

  12. Ciapparelli A, Ducci F, Carmassi C, Carlini M, Paggini R, Catena M et al. Predictors of response in a sample of treatment-resistant psychotic patients on clozapine. Eur Arch Psychiatry Clin Neurosci. 2004;254(5):343-6.

  13. Umbricht DS, Wirshing WC, Wirshing DA, McMeniman M, Schooler NR, Marder SR et al. Clinical predictors of response to clozapine treatment in ambulatory patients with schizophrenia. J Clin Psychiatry. 2002;63(5):420-4.

  14. Nielsen J, Nielsen RE, Correll CU. Predictors of Clozapine Response in Patients With Treatment-Refractory Schizophrenia. J Clin Psychiatry. 2012;32(5):678-83.

  15. Lieberman JA, Safferman AZ, Pollack S, Szymanski S, Johns C, Howard A et al. Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome. Am J Psychiatry. 1994;151(12):1744-52.

  16. Szymanski S, Lieberman J, Pollack S, Kane JM, Safferman A, Munne R et al. Gender differences in neuroleptic nonresponsive clozapine-treated schizophrenics. Biol Psychiatry. 1996;39(4):249-54.

  17. Perry PJ, Miller DD, Arndt SV, Cadoret RJ. Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. Am J Psychiatry. 1991;148(2):231-5.

  18. Alberich S, Fernández-Sevillano J, González-Ortega I, Usall J, Sáenz M, González-Fraile E et al. A systematic review of sex-based differences in effectiveness and adverse effects of clozapine. Psychiatry Res. 2019;280:112506.

  19. Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA. Clozapine-induced agranulocytosis Incidence and risk factors in the United States. N Engl J Med. 1993;329(3):162-7.

  20. Balda MV, Garay OU, Papale RM, Bignone I, Bologna VG, Brandolini A et al. Clozapine-associated neutropenia and agranulocytosis in Argentina (2007-2012). Int Clin Psychopharmacol. 2015;30(2):109-14.

  21. Hollingworth SA, Winckel K, Saiepour N, Wheeler AJ, Myles N, Siskind D. Clozapine-related neutropenia, myocarditis and cardiomyopathy adverse event reports in Australia 1993-2014. Psychopharmacology (Berl). 2018;235(7):1915-1921.

  22. Atkin K, Kendall F, Gould D, Freeman H, Liberman J, O'Sullivan D. Neutropenia and agranulocytosis in patients receiving clozapine in the UK and Ireland. Br J Psychiatry. 1996;169(4):483-8.

  23. Seeman MV. Men and women respond differently to antipsychotic drugs. Neuropharmacology. 2020;163:107631.

  24. Covell NH, Weissman EM, Essock SM. Weight gain with clozapine compared to first generation antipsychotic medications. Schizophr Bull. 2004;30(2):229-40.

  25. Lau SL, Muir C, Assur Y, Beach R, Tran B, Bartrop R et al. Predicting Weight Gain in Patients Treated With Clozapine: The Role of Sex, Body Mass Index, and Smoking. J Clin Psychopharmacol. 2016;36(2):120-4.

  26. Wu RR, Zhao JP, Zhai JG, Guo XF, Guo WB. Sex difference in effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia. J Clin Psychopharmacol. 2007;27:374-9.

  27. Meltzer HY, Perry E, Jayathilake K. Clozapine-induced weight gain predicts improvement in psychopathology. Schizophr Res. 2003;59(1):19-27.

  28. Woosley, RL; Heise, CW; Gallo, T; Woosley, RD; and Romero, KA. QTFactors List. CredibleMeds [www]. AZCERT Inc. [cited 2020-08-31].

  29. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2019 [cited 2020-03-10.]

  1. Leponex (klozapin). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2019-09-22, cited 2020-08-25]
  2. Krivoy A, Gaughran F, Weizman A, Breen G, MacCabe JH. Gene polymorphisms potentially related to the pharmacokinetics of clozapine: a systematic review. Int Clin Psychopharmacol. 2016;31(4):179-84.
  3. Eiermann B, Engel G, Johansson I, Zanger UM, Bertilsson L. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br J Clin Pharmacol. 1997;44(5):439-46.
  4. Albitar O, Harun SN, Zainal H, Ibrahim B, Sheikh Ghadzi SM. Population Pharmacokinetics of Clozapine: A Systematic Review. Biomed Res Int. 2020;2020:9872936.
  5. Mayerova M, Ustohal L, Jarkovsky J, Pivnicka J, Kasparek T, Ceskova E. Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations. Neuropsychiatr Dis Treat. 2018;14:1535-1543.
  6. Aichhorn W, Whitworth AB, Weiss EM, Marksteiner J. Second-generation antipsychotics: is there evidence for sex differences in pharmacokinetic and adverse effect profiles?. Drug Saf. 2006;29(7):587-98.
  7. Ng W, Uchida H, Ismail Z, Mamo DC, Rajji TK, Remington G et al. Clozapine exposure and the impact of smoking and gender: a population pharmacokinetic study. Ther Drug Monit. 2009;31(3):360-6.
  8. Rostami-Hodjegan A, Amin AM, Spencer EP, Lennard MS, Tucker GT, Flanagan RJ. Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients. J Clin Psychopharmacol. 2004;24(1):70-8.
  9. Janusmed Interactions. Stockholm: Region Stockholm. 2020 [updated 2020-08-19, cited 2020-08-26.]
  10. Stockley’s Drug Interactions. London: Royal Pharmaceutical Society. 2020 [updated 2020-08-11, cited 2020-08-26.]
  11. Usall J, Suarez D, Haro JM, SOHO Study Group. Gender differences in response to antipsychotic treatment in outpatients with schizophrenia. Psychiatry Res. 2007;153:225-31.
  12. Ciapparelli A, Ducci F, Carmassi C, Carlini M, Paggini R, Catena M et al. Predictors of response in a sample of treatment-resistant psychotic patients on clozapine. Eur Arch Psychiatry Clin Neurosci. 2004;254(5):343-6.
  13. Umbricht DS, Wirshing WC, Wirshing DA, McMeniman M, Schooler NR, Marder SR et al. Clinical predictors of response to clozapine treatment in ambulatory patients with schizophrenia. J Clin Psychiatry. 2002;63(5):420-4.
  14. Nielsen J, Nielsen RE, Correll CU. Predictors of Clozapine Response in Patients With Treatment-Refractory Schizophrenia. J Clin Psychiatry. 2012;32(5):678-83.
  15. Lieberman JA, Safferman AZ, Pollack S, Szymanski S, Johns C, Howard A et al. Clinical effects of clozapine in chronic schizophrenia: response to treatment and predictors of outcome. Am J Psychiatry. 1994;151(12):1744-52.
  16. Szymanski S, Lieberman J, Pollack S, Kane JM, Safferman A, Munne R et al. Gender differences in neuroleptic nonresponsive clozapine-treated schizophrenics. Biol Psychiatry. 1996;39(4):249-54.
  17. Perry PJ, Miller DD, Arndt SV, Cadoret RJ. Clozapine and norclozapine plasma concentrations and clinical response of treatment-refractory schizophrenic patients. Am J Psychiatry. 1991;148(2):231-5.
  18. Alberich S, Fernández-Sevillano J, González-Ortega I, Usall J, Sáenz M, González-Fraile E et al. A systematic review of sex-based differences in effectiveness and adverse effects of clozapine. Psychiatry Res. 2019;280:112506.
  19. Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA. Clozapine-induced agranulocytosis Incidence and risk factors in the United States. N Engl J Med. 1993;329(3):162-7.
  20. Balda MV, Garay OU, Papale RM, Bignone I, Bologna VG, Brandolini A et al. Clozapine-associated neutropenia and agranulocytosis in Argentina (2007-2012). Int Clin Psychopharmacol. 2015;30(2):109-14.
  21. Hollingworth SA, Winckel K, Saiepour N, Wheeler AJ, Myles N, Siskind D. Clozapine-related neutropenia, myocarditis and cardiomyopathy adverse event reports in Australia 1993-2014. Psychopharmacology (Berl). 2018;235(7):1915-1921.
  22. Atkin K, Kendall F, Gould D, Freeman H, Liberman J, O'Sullivan D. Neutropenia and agranulocytosis in patients receiving clozapine in the UK and Ireland. Br J Psychiatry. 1996;169(4):483-8.
  23. Seeman MV. Men and women respond differently to antipsychotic drugs. Neuropharmacology. 2020;163:107631.
  24. Covell NH, Weissman EM, Essock SM. Weight gain with clozapine compared to first generation antipsychotic medications. Schizophr Bull. 2004;30(2):229-40.
  25. Lau SL, Muir C, Assur Y, Beach R, Tran B, Bartrop R et al. Predicting Weight Gain in Patients Treated With Clozapine: The Role of Sex, Body Mass Index, and Smoking. J Clin Psychopharmacol. 2016;36(2):120-4.
  26. Wu RR, Zhao JP, Zhai JG, Guo XF, Guo WB. Sex difference in effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia. J Clin Psychopharmacol. 2007;27:374-9.
  27. Meltzer HY, Perry E, Jayathilake K. Clozapine-induced weight gain predicts improvement in psychopathology. Schizophr Res. 2003;59(1):19-27.
  28. Woosley, RL; Heise, CW; Gallo, T; Woosley, RD; and Romero, KA. QTFactors List. CredibleMeds [www]. AZCERT Inc. [cited 2020-08-31].
  29. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2019 [cited 2020-03-10.]