Bensoylperoxid
Bensoylperoxid
Klass: B
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Produkter
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Basiron AC, Basiron AC Wash, Brevoxyl, Clinzoyl, Duac, ......
Basiron AC, Basiron AC Wash, Brevoxyl, Clinzoyl, Duac, Epiduo, StioxylATC-koder
D10AD53, D10AE01, D10AF51
D10AD53, D10AE01, D10AF51Substanser
bensoylperoxid
bensoylperoxidSammanfattning
Det saknas studier med relevant könsanalys på bara bensoylperoxid. I post hoc analyser av kombinationsbehandling av gel med bensoylperoxid samt klindamycin har likvärdig tolerabilitet hos båda könen men bättre effekt på acne påvisats hos kvinnor/flickor, framförallt under tonåren.
Det saknas studier med relevant könsanalys på bara bensoylperoxid. I post hoc analyser av kombinationsbehandling av gel med bensoylperoxid samt klindamycin har likvärdig tolerabilitet hos båda könen men bättre effekt på acne påvisats hos kvinnor/flickor, framförallt under tonåren.Background
Pharmacokinetics and dosing
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No studies with a clinically relevant sex analysis regarding pharmacokinetics or dosing of bensoyl peroxide have been found. Transdermal absorption seems to be similar in men and women [6].
Effects
The efficacy of clindamycin phosphate 1.2%/ bensoyl peroxide 3.75% gel was found to be greater than vehicle in both men and women but with a more pronounced effect in women [7].
In a post hoc analysis (including 797 men and women) of two studies evaluating efficacy and tolerability of clindamycin phosphate 1.2%/ bensoyl peroxide 2.5% gel (in all 2813 persons included) adolescent girls had better effect than adolescent boys [8].
Adverse effects
In the post hoc analysis mentioned above, bensoyl peroxide tolerability was reported to be comparable in males and females [8].
A retrospective study of patch tests (12 087 men, 17 671 women) found positive reactions to be rather common (7.8%). Logistic regression showed female sex to be one of the factors associated with a higher risk of a strong positive reaction. However, the authors caution that as sensitization......
Försäljning på recept
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Läkemedel innehållande endast bensoylperoxid (ATC-kod D10AE01) köps huvudsakligen receptfritt och därför saknas könsspecifika användningsdata [11]. # Kombinationsprodukter Fler kvinnor än män hämtade ut gel innehållande klindamycin i kombination med tretinoin eller bensoylperoxid (ATC-kod D10AF51) på recept i Sverige år 2015, totalt 11 551 kvinnor och 6 014 män. Det motsvarar 2,4 respektive 1,2 patienter per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 15-19 år hos båda könen. I genomsnitt var gel innehållande klindamycin i kombination med tretinoin eller bensoylperoxid 2,7 gånger vanligare hos kvinnor [12]. Fler kvinnor än män hämtade ut läkemedel innehållande kombination av bensoylperoxid och adapalen (ATC-kod D10AD53) på recept i Sverige år 2015, totalt 13 093 kvinnor och 8 212 män. Det motsvarar 2,7 respektive 1,7 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 15-19 år hos båda könen. I genomsnitt var läkemedel innehållande kombination av bensoylperoxid och adapalen 1,6 gånger vanligare hos kvinnor [12].
Referenser
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Lello J, Pearl A, Arroll B, Yallop J, Birchall NM. Prevalence of acne vulgaris in Auckland senior high school students. N Z Med J. 1995;108:287-9.
Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J Am Acad Dermatol. 1999;41:577-80.
Berg M, Lindberg M. Possible gender differences in the quality of life and choice of therapy in acne. J Eur Acad Dermatol Venereol. 2011;25:969-72.
Youn SH, Choi CW, Choi JW, Youn SW. The skin surface pH and its different influence on the development of acne lesion according to gender and age. Skin Res Technol. 2013;19:131-6.
Kim BY, Choi JW, Park KC, Youn SW. Sebum, acne, skin elasticity, and gender difference - which is the major influencing factor for facial pores?. Skin Res Technol. 2013;19:e45-53.
Harper JC. The efficacy and tolerability of a fixed combination clindamycin (12%) and benzoyl peroxide (375%) aqueous gel in patients with facial acne vulgaris: gender as a clinically relevant outcome variable. J Drugs Dermatol. 2015;14:381-4.
Harper JC. Gender as a clinically relevant outcome variable in acne: benefits of a fixed combination clindamycin phosphate (12%) and benzoyl peroxide (25%) aqueous gel. J Drugs Dermatol. 2012;11:1440-5.
Ockenfels HM, Uter W, Lessmann H, Schnuch A, Geier J. Patch testing with benzoyl peroxide: reaction profile and interpretation of positive patch test reactions. Contact Dermatitis. 2009;61:209-16.
Thevarajah S, Balkrishnan R, Camacho FT, Feldman SR, Fleischer AB. Trends in prescription of acne medication in the US: shift from antibiotic to non-antibiotic treatment. J Dermatolog Treat. 2005;16:224-8.
Conicse. Stockholm: eHälsomyndigheten. 2015 [cited 2016-03-23.]
Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-06-30.]
- Lello J, Pearl A, Arroll B, Yallop J, Birchall NM. Prevalence of acne vulgaris in Auckland senior high school students. N Z Med J. 1995;108:287-9.
- Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J Am Acad Dermatol. 1999;41:577-80.
- Berg M, Lindberg M. Possible gender differences in the quality of life and choice of therapy in acne. J Eur Acad Dermatol Venereol. 2011;25:969-72.
- Youn SH, Choi CW, Choi JW, Youn SW. The skin surface pH and its different influence on the development of acne lesion according to gender and age. Skin Res Technol. 2013;19:131-6.
- Kim BY, Choi JW, Park KC, Youn SW. Sebum, acne, skin elasticity, and gender difference - which is the major influencing factor for facial pores?. Skin Res Technol. 2013;19:e45-53.
- Harper JC. The efficacy and tolerability of a fixed combination clindamycin (12%) and benzoyl peroxide (375%) aqueous gel in patients with facial acne vulgaris: gender as a clinically relevant outcome variable. J Drugs Dermatol. 2015;14:381-4.
- Harper JC. Gender as a clinically relevant outcome variable in acne: benefits of a fixed combination clindamycin phosphate (12%) and benzoyl peroxide (25%) aqueous gel. J Drugs Dermatol. 2012;11:1440-5.
- Ockenfels HM, Uter W, Lessmann H, Schnuch A, Geier J. Patch testing with benzoyl peroxide: reaction profile and interpretation of positive patch test reactions. Contact Dermatitis. 2009;61:209-16.
- Thevarajah S, Balkrishnan R, Camacho FT, Feldman SR, Fleischer AB. Trends in prescription of acne medication in the US: shift from antibiotic to non-antibiotic treatment. J Dermatolog Treat. 2005;16:224-8.
- Conicse. Stockholm: eHälsomyndigheten. 2015 [cited 2016-03-23.]
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-06-30.]
Uppdaterat
Litteratursökningsdatum 6/15/2016
Litteratursökningsdatum 6/15/2016Se även
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