Beklometason
Beklometason
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Produkter
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AeroBec, AeroBec Autohaler, Beclomet Easyhaler, Becotid......
AeroBec, AeroBec Autohaler, Beclomet Easyhaler, Becotide, Becotide Nasal, Innovair, Innovair nexthaler, TrimbowATC-koder
R01AD01, R03AK08, R03AL09, R03BA01
R01AD01, R03AK08, R03AL09, R03BA01Substanser
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beklometason, beklometasondipropionat (vattenfritt), be......
beklometason, beklometasondipropionat (vattenfritt), beklometasondipropionatmonohydratSammanfattning
En subgruppsanalys av en randomiserad kontrollerad studie visade inga könsskillnader i effekt av beklometason nässpray. Det saknas större kontrollerade studier avseende könsskillnader i effekt.
En kohortstudie på barn visade att pojkar som använt kortikosteroider som inhalation hade högre frakturrisk jämfört med flickor. Det saknas publicerade kliniska studier avseende könsskillnader i biverkningar hos barn och vuxna.
En mindre studie fann generellt sämre inhalationsteknik hos kvinnor vilket gav lägre effektiv dos.
Background
COPD (chronic obstructive pulmonary disease) affects more women than men and women often get a more serious and rapidly progressive disease [1]. Adult asthma is more common in women while childhood asthma is more common in boys. The reversal of this sex difference in prevalence occurs around puberty which suggests that sex hormones may play a role in the etiology of asthma [2]. However, some studies suggest that there are sex differences in expression and diagnosing of asthma, and it has been discussed if women are under-treated for respiratory diseases or not [3, 4]. Visa hela bakgrundstexten
Pharmacokinetics and dosing
The influence of sex on the pharmacokinetics of QVAR REDIHALER (beclomethasone dipropionate HFA) has not been studied [5].
Effects
In a subgroup analysis of a randomized, double-blind, placebo-controlled study of the efficacy of beclomethasone dipropionate nasal aerosol, no significant sex differences in efficacy were found. However, it was hard to draw conclusions from the subgroup analysis because of the small sample size of the subgroup [6].
Adverse effects
In a population-based coh......
Försäljning på recept
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Fler kvinnor än män hämtade läkemedel innehållande kombination av beklometason och formoterol (ATC-kod R03AK08) i Sverige år 2019, totalt 17 327 kvinnor och 10 413 män. Det motsvarar 3,4 respektive 2,0 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 75 år och äldre hos båda könen. I åldersgruppen 0-14 år var läkemedel innehållande kombination av beklometason och formoterol i genomsnitt 1,4 gångar vanligare hos män och i åldersgruppen 15 år och äldre 1,6 gånger vanligare hos kvinnor [13]. Fler kvinnor än män hämtade ut inhalationsspray innehållande beklometason (ATC-kod R03AB01) på recept i Sverige år 2019, totalt 2 004 kvinnor och 1 190 män. Det motsvarar 3,9 respektive 2,3 personer per tiotusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 75 år och äldre hos båda könen. Totalt sett var inhalationsspray innehållande beklometason 1,7 gånger vanligare hos kvinnor [13].
Referenser
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Nationella riktlinjer för vård vid astma och kroniskt obstruktiv lungsjukdom (KOL). Socialstyrelsen. [updated 2018-01-29, cited 2020-09-14].
Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019;7:246.
Dales RE, Mehdizadeh A, Aaron SD, Vandemheen KL, Clinch J. Sex differences in the clinical presentation and management of airflow obstruction. Eur Respir J. 2006;28:319-22.
Tantisira KG, Colvin R, Tonascia J, Strunk RC, Weiss ST, Fuhlbrigge AL et al. Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med. 2008;178:325-31.
QVAR REDIHALER (beclomethasone). DailyMed [www]. [updated 2020-10-14, cited 2020-12-02].
U.S. Food and Drug Administration. Medical Review - QNASL (beclometahosone). Drugs@FDA [www]. [updated 2013-06-10, cited 2020-12-02].
van Staa TP, Bishop N, Leufkens HG, Cooper C. Are inhaled corticosteroids associated with an increased risk of fracture in children?. Osteoporos Int. 2004;15(10):785-91.
Ferrajolo C, Sultana J, Ientile V, Scavone C, Scondotto G, Tari M et al. Gender Differences in Outpatient Pediatric Drug Utilization: A Cohort Study From Southern Italy. Front Pharmacol. 2019;10:11.
Goodman DE, Israel E, Rosenberg M, Johnston R, Weiss ST, Drazen JM. The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med. 1994;150:1256-61.
Osborne ML, Vollmer WM, Linton KL, Buist AS. Characteristics of patients with asthma within a large HMO: a comparison by age and gender. Am J Respir Crit Care Med. 1998;157:123-8.
Prescott E, Lange P, Vestbo J. Effect of gender on hospital admissions for asthma and prevalence of self-reported asthma: a prospective study based on a sample of the general population Copenhagen City Heart Study Group. Thorax. 1997;52:287-9.
Ng TP, Niti M, Tan WC. Trends and ethnic differences in asthma hospitalization rates in Singapore, 1991 to 1998. Ann Allergy Asthma Immunol. 2003;90:51-5.
Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2019 [cited 2020-03-10.]
- Nationella riktlinjer för vård vid astma och kroniskt obstruktiv lungsjukdom (KOL). Socialstyrelsen. [updated 2018-01-29, cited 2020-09-14].
- Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019;7:246.
- Dales RE, Mehdizadeh A, Aaron SD, Vandemheen KL, Clinch J. Sex differences in the clinical presentation and management of airflow obstruction. Eur Respir J. 2006;28:319-22.
- Tantisira KG, Colvin R, Tonascia J, Strunk RC, Weiss ST, Fuhlbrigge AL et al. Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med. 2008;178:325-31.
- QVAR REDIHALER (beclomethasone). DailyMed [www]. [updated 2020-10-14, cited 2020-12-02].
- U.S. Food and Drug Administration. Medical Review - QNASL (beclometahosone). Drugs@FDA [www]. [updated 2013-06-10, cited 2020-12-02].
- van Staa TP, Bishop N, Leufkens HG, Cooper C. Are inhaled corticosteroids associated with an increased risk of fracture in children?. Osteoporos Int. 2004;15(10):785-91.
- Ferrajolo C, Sultana J, Ientile V, Scavone C, Scondotto G, Tari M et al. Gender Differences in Outpatient Pediatric Drug Utilization: A Cohort Study From Southern Italy. Front Pharmacol. 2019;10:11.
- Goodman DE, Israel E, Rosenberg M, Johnston R, Weiss ST, Drazen JM. The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med. 1994;150:1256-61.
- Osborne ML, Vollmer WM, Linton KL, Buist AS. Characteristics of patients with asthma within a large HMO: a comparison by age and gender. Am J Respir Crit Care Med. 1998;157:123-8.
- Prescott E, Lange P, Vestbo J. Effect of gender on hospital admissions for asthma and prevalence of self-reported asthma: a prospective study based on a sample of the general population Copenhagen City Heart Study Group. Thorax. 1997;52:287-9.
- Ng TP, Niti M, Tan WC. Trends and ethnic differences in asthma hospitalization rates in Singapore, 1991 to 1998. Ann Allergy Asthma Immunol. 2003;90:51-5.
- Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2019 [cited 2020-03-10.]
Uppdaterat
Litteratursökningsdatum: 12/2/2020
Litteratursökningsdatum: 12/2/2020