Levonorgestrel
Levonorgestrel
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Abelonelle 28, Anastrella 28, Erlibelle, Jadelle, Jadelle sine inserte......
Abelonelle 28, Anastrella 28, Erlibelle, Jadelle, Jadelle sine inserter, Jaydess, Kyleena, Leverette, Leverette 21, Levesia, Levonorgestrel/Etinylestradiol 2care4, Levonorgestrel/Etinylestradiol Ebb, Levosert, Levosertone, Loette 28, Mirena, Neovletta, Neovletta 28, Novogyn, Prionelle, Prionelle 28, Rigevidon, Rigevidoncont, Trinordiol, Trinordiol 28, Trionetta, Trionetta 28, TriregolATC-koder
G02BA03, G03AA07, G03AB03, G03AC03
G02BA03, G03AA07, G03AB03, G03AC03Substanser
levonorgestrel
levonorgestrelRekommendation för hälso- och sjukvården
Risken för barnet anses vara låg vid terapeutiska doser.
Risken för barnet anses vara låg vid terapeutiska doser.Råd till allmänheten
Går bra att använda under amning
Går bra att använda under amningBakgrund
Levonorgestrel passerar över till bröstmjölk. Baserat på data från 98 kvinnor med doser mellan 10-150 µg (oralt, implantat eller intrauterint inlägg) kan den relativa barndosen beräknas till 3,8 % (1-6). Koncentrationer upp till 0,115 ng/mL har uppmätts hos 83 barn (2,5,7). Ingen påverkan på bröstmjölksproduktionen kunde påvisas hos 642 kvinnor (8–11, 20–21). Däremot kunde en viss minskning av bröstmjölksproduktionen påvisas hos 40 kvinnor med 30 µg levonorgestrel i form av intrauterint inlägg (12). Inga negativa effekter på barns tillväxt eller utveckling har rapporterats hos 1028 ammade barn (8,9,11–15, 20–21). Låga TSH nivåer har rapporterats hos 20 barn (16). Något högre incidens av milda infekti...... Visa hela bakgrundstexten
Referenser
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Saxena BN, Shrimanker K, Grudzinskas JG. Levels of contraceptive seroids in breast milk and plasma of lactating women. Contraception 1977;16(6):605-613.
Nilsson S, Nygren KG, Johansson ED. d-Norgestrel concentrations in maternal plasma, milk, and child plasma during administration of oral contraceptives to nursing women. Am J Obstet Gynecol 1977;129(2):178-84.
Betrabet SS, Shikary ZK, Toddywalla VS, Toddywalla SP, Patel D, Saxena BN. ICMR Task Force Study on hormonal contraception. Transfer of norethisterone (NET) and levonorgestrel (LNG) from a single tablet into the infant's circulation through the mother's milk. Contraception 1987;35(6):517-522.
Toddywalla VS, Mehta S, Virkar KD, Saxena BN. Release of 19-nor-testosterone type of contraceptive steroids through different drug delivery systems into serum and breast milk of lactating women. Contraception. 1980;21(3):217-23.
Shikary ZK, Betrabet SS, Patel ZM, Patel S, Joshi JV, Toddywala VS et al. ICMR task force study on hormonal contraception Transfer of levonorgestrel (LNG) administered through different drug delivery systems from the maternal circulation into the newborn infant's circulation via breast milk. Contraception. 1987;35(5):477-86.
Heikkilä M, Haukkamaa M, Luukkainen T. Levonorgestrel in milk and plasma of breast-feeding women with a levonorgestrel-releasing IUD. Contraception. 1982;25(1):41-9.
Shaaban MM, Odlind V, Salem HT, Abdullah KA, Gomaa AA. Levonorgestrel concentrations in maternal and infant serum during use of subdermal levonorgestrel contraceptive implants, Norplant, by nursing mothers. Contraception. 1986;33(4):357-63.
Affandi B, Karmadibrata S, Prihartono J, Lubis F, Samil RS. Effect of Norplant on mothers and infants in the postpartum period. Adv Contracept. 1986;2(4):371-80.
Shaamash AH, Sayed GH, Hussien MM, Shaaban MM. A comparative study of the levonorgestrel-releasing intrauterine system Mirena versus the Copper T380A intrauterine device during lactation: breast-feeding performance, infant growth and infant development. Contraception. 2005;72(5):346-51.
Shaaban MM, Salem HT, Abdullah KA. Influence of levonorgestrel contraceptive implants, NORPLANT, initiated early postpartum upon lactation and infant growth. Contraception. 1985;32(6):623-35.
McCann MF, Moggia AV, Higgins JE, Potts M, Becker C. The effects of a progestin-only oral contraceptive (levonorgestrel 003 mg) on breast-feeding. Contraception. 1989;40(6):635-48.
Heikkilä M, Luukkainen T. Duration of breast-feeding and development of children after insertion of a levonorgestrel-releasing intrauterine contraceptive device. Contraception. 1982;25(3):279-92.
Schiappacasse V, Diaz S, Zepeda A, Alvarado R, Herreros C. Health and growth of infants breastfed by Norplant contraceptive implants users: a six-year follow-up study. Contraception 2002;66(1):57-65.
Croxatto HB, Díaz S, Peralta O, Juez G, Herreros C, Casado ME et al. Fertility regulation in nursing women: IV Long-term influence of a low-dose combined oral contraceptive initiated at day 30 postpartum upon lactation and infant growth. Contraception. 1983;27(1):13-25.
Peralta O, Díaz S, Juez G, Herreros C, Casado ME, Salvatierra AM et al. Fertility regulation in nursing women: V Long-term influence of a low-dose combined oral contraceptive initiated at day 90 postpartum upon lactation and infant growth. Contraception. 1983;27(1):27-38.
Bassol S, Nava-Hernandez MP, Hernandez-Morales C, Trujillo-Macias AM, Lopez-Lozano MR, Recio R. Effects of levonorgestrel implant upon TSH and LH levels in male infants during lactation. Int J Gynaecol Obstet 2002;76(3):273-7.
Antikonception-behandlingsrekommendation. Information från Läkemedelsverket. 2014:2;14-28
Progestogen-only contraceptives during lactation: I. Infant growth. World Health Organization Task force for Epidemiological Research on Reproductive Health; Special Programme of Research, Development and Research Training in Human Reproduction. Contraception 1994;50(1):35-53.
Progestogen-only contraceptives during lactation: II. Infant development. World Health Organization, Task Force for Epidemiological Research on Reproductive Health; Special Programme of Research, Development, and Research Training in Human Reproduction. Contraception 1994;50(1):55-68.
Averbach S, Kakaire O, McDiehl R, Dehlendorf C, Lester F, Steinauer J. The effect of immediate postpartum levonorgestrel contraceptive implant use on breastfeeding and infant growth: a randomized controlled trial. Contraception. 2019;99(2):87-93.
Hopelian NG, Simmons RG, Sanders JN, Ward K, Jenkins SM, Espey E et al. Comparison of levonorgestrel level and creamatocrit in milk following immediate versus delayed postpartum placement of the levonorgestrel IUD. BMC Womens Health. 2021;21(1):33.
- Saxena BN, Shrimanker K, Grudzinskas JG. Levels of contraceptive seroids in breast milk and plasma of lactating women. Contraception 1977;16(6):605-613.
- Nilsson S, Nygren KG, Johansson ED. d-Norgestrel concentrations in maternal plasma, milk, and child plasma during administration of oral contraceptives to nursing women. Am J Obstet Gynecol 1977;129(2):178-84.
- Betrabet SS, Shikary ZK, Toddywalla VS, Toddywalla SP, Patel D, Saxena BN. ICMR Task Force Study on hormonal contraception. Transfer of norethisterone (NET) and levonorgestrel (LNG) from a single tablet into the infant's circulation through the mother's milk. Contraception 1987;35(6):517-522.
- Toddywalla VS, Mehta S, Virkar KD, Saxena BN. Release of 19-nor-testosterone type of contraceptive steroids through different drug delivery systems into serum and breast milk of lactating women. Contraception. 1980;21(3):217-23.
- Shikary ZK, Betrabet SS, Patel ZM, Patel S, Joshi JV, Toddywala VS et al. ICMR task force study on hormonal contraception Transfer of levonorgestrel (LNG) administered through different drug delivery systems from the maternal circulation into the newborn infant's circulation via breast milk. Contraception. 1987;35(5):477-86.
- Heikkilä M, Haukkamaa M, Luukkainen T. Levonorgestrel in milk and plasma of breast-feeding women with a levonorgestrel-releasing IUD. Contraception. 1982;25(1):41-9.
- Shaaban MM, Odlind V, Salem HT, Abdullah KA, Gomaa AA. Levonorgestrel concentrations in maternal and infant serum during use of subdermal levonorgestrel contraceptive implants, Norplant, by nursing mothers. Contraception. 1986;33(4):357-63.
- Affandi B, Karmadibrata S, Prihartono J, Lubis F, Samil RS. Effect of Norplant on mothers and infants in the postpartum period. Adv Contracept. 1986;2(4):371-80.
- Shaamash AH, Sayed GH, Hussien MM, Shaaban MM. A comparative study of the levonorgestrel-releasing intrauterine system Mirena versus the Copper T380A intrauterine device during lactation: breast-feeding performance, infant growth and infant development. Contraception. 2005;72(5):346-51.
- Shaaban MM, Salem HT, Abdullah KA. Influence of levonorgestrel contraceptive implants, NORPLANT, initiated early postpartum upon lactation and infant growth. Contraception. 1985;32(6):623-35.
- McCann MF, Moggia AV, Higgins JE, Potts M, Becker C. The effects of a progestin-only oral contraceptive (levonorgestrel 003 mg) on breast-feeding. Contraception. 1989;40(6):635-48.
- Heikkilä M, Luukkainen T. Duration of breast-feeding and development of children after insertion of a levonorgestrel-releasing intrauterine contraceptive device. Contraception. 1982;25(3):279-92.
- Schiappacasse V, Diaz S, Zepeda A, Alvarado R, Herreros C. Health and growth of infants breastfed by Norplant contraceptive implants users: a six-year follow-up study. Contraception 2002;66(1):57-65.
- Croxatto HB, Díaz S, Peralta O, Juez G, Herreros C, Casado ME et al. Fertility regulation in nursing women: IV Long-term influence of a low-dose combined oral contraceptive initiated at day 30 postpartum upon lactation and infant growth. Contraception. 1983;27(1):13-25.
- Peralta O, Díaz S, Juez G, Herreros C, Casado ME, Salvatierra AM et al. Fertility regulation in nursing women: V Long-term influence of a low-dose combined oral contraceptive initiated at day 90 postpartum upon lactation and infant growth. Contraception. 1983;27(1):27-38.
- Bassol S, Nava-Hernandez MP, Hernandez-Morales C, Trujillo-Macias AM, Lopez-Lozano MR, Recio R. Effects of levonorgestrel implant upon TSH and LH levels in male infants during lactation. Int J Gynaecol Obstet 2002;76(3):273-7.
- Antikonception-behandlingsrekommendation. Information från Läkemedelsverket. 2014:2;14-28
- Progestogen-only contraceptives during lactation: I. Infant growth. World Health Organization Task force for Epidemiological Research on Reproductive Health; Special Programme of Research, Development and Research Training in Human Reproduction. Contraception 1994;50(1):35-53.
- Progestogen-only contraceptives during lactation: II. Infant development. World Health Organization, Task Force for Epidemiological Research on Reproductive Health; Special Programme of Research, Development, and Research Training in Human Reproduction. Contraception 1994;50(1):55-68.
- Averbach S, Kakaire O, McDiehl R, Dehlendorf C, Lester F, Steinauer J. The effect of immediate postpartum levonorgestrel contraceptive implant use on breastfeeding and infant growth: a randomized controlled trial. Contraception. 2019;99(2):87-93.
- Hopelian NG, Simmons RG, Sanders JN, Ward K, Jenkins SM, Espey E et al. Comparison of levonorgestrel level and creamatocrit in milk following immediate versus delayed postpartum placement of the levonorgestrel IUD. BMC Womens Health. 2021;21(1):33.
Författare
Klinisk farmakologi, Karolinska Universitetssjukhuset för Hälso- och sjukvårdsförvaltningen, Region Stockholm. Janusmed amning uppdateras kvartalsvis.
Klinisk farmakologi, Karolinska Universitetssjukhuset för Hälso- och sjukvårdsförvaltningen, Region Stockholm. Janusmed amning uppdateras kvartalsvis.För patienter och allmänhet
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Innehållet senast uppdaterat 2024-11-07