Lamotrigin
Lamotrigin
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Crisomet, Labileno, Lamictal, Lamictal 25 mg disperguojamosios, Lamoca......
Crisomet, Labileno, Lamictal, Lamictal 25 mg disperguojamosios, Lamocare, Lamotrigin 1A Farma, Lamotrigin 2care4, Lamotrigin Abacus Medicine, Lamotrigin Actavis, Lamotrigin Aristo, Lamotrigin Arrow, Lamotrigin Aurobindo, Lamotrigin BMM Pharma, Lamotrigin Bluefish, Lamotrigin EQL, Lamotrigin Ebb, Lamotrigin Hexal, Lamotrigin Medochemie, Lamotrigin Mylan, Lamotrigin Orifarm, Lamotrigin Orion, Lamotrigin Teva, Lamotrigin ratiopharmATC-koder
N03AX09
N03AX09Substanser
lamotrigin
lamotriginRekommendation för hälso- och sjukvården
Risken för barnet förväntas vara måttlig vid terapeutiska doser. Om amning inleds bör moderns plasmakoncentration följas noga och barnet bör observeras med avseende på biverkningar (såsom sedering och hudsymtom). Koncentrationsbestämning hos barnet kan övervägas.
Risken för barnet förväntas vara måttlig vid terapeutiska doser. Om amning inleds bör moderns plasmakoncentration följas noga och barnet bör observeras med avseende på biverkningar (såsom sedering och hudsymtom). Koncentrationsbestämning hos barnet kan övervägas.Råd till allmänheten
Kontakta läkare för diskussion innan behandling påbörjas.
Kontakta läkare för diskussion innan behandling påbörjas.Bakgrund
Passerar över till bröstmjölk i hög grad. Baserat på data från 67 kvinnor har den relativa barndosen beräknats till i medel ca 11 % (intervall 2-30 %) (1-4,13,15, 28, 29). Plasmakoncentrationer upp till 50 µM har uppmätts (mätningar gjorda hos minst 129 barn) (1-6,12-19,23-26,30) (terapeutiska koncentrationer 10-60 µM). Mer än 90 barn har observerats utan att några negativa effekter har rapporterats (1-10,13-17,20,28). Barn som exponerats in utero för lamotrigin och hade a...... Visa hela bakgrundstexten
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Rambeck B, Kurlemann G, Stodieck SR, May TW, Jurgens U. Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child. Eur J Clin Pharmacol 1997;51(6):481-484
Tomson T, Öhman I, Vitols S. Lamotrigine in pregnancy and lactation: a case report. Epilepsia 1997;38(9):1039-1041
Öhman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41(6):709-713
Page-Sharp M, Kristensen JH, Hackett LP, Beran RG, Rampono J, Hale TW et al. Transfer of lamotrigine into breast milk. Ann Pharmacother 2006;40(7-8):1470-1471
Liporace J, Kao A, DAbreu A. Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav 2004;5(1):102-105
Ivana K, Milan G, Blanka K, Hana B. Therapeutic monitoring of lamotrigine during delivery, in the neonatal period, and during lactation. Ther Drug Monit 2007;29(4):477
Gentile S. Lamotrigine in pregnancy and lactation. Arch Womens Ment Health 2005;8(1):57-8.
Pennell P, Ritchie J, Newport D, Liporace J, Montgomery J, Newman M et al. Pharmacokinetics of lamotrigine excretion into human breast milk. Neurology 2006;66(5;Suppl 2):A72-A73
Berry DJ. The disposition of lamotrigine throughout pregnancy. Ther Drug Monit 1999;21(4):450
Öhman I, Tomson T, Vitols S. Lamotrigine (LTG) pharmacokinetics during delivery and lactation. Ther Drug Monit 1999;21(4):478
Popescu L, Marceanu M, Moleavin I. Withdrawal of lamotrigine caused by sudden weaning of a newborn: a case report. Epilepsia 2005;46(suppl 6):407
Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009;43:1893-7.
Newport DJ, Pennell PB, Calamaras MR, Ritchie JC, Newman M, Knight B et al. Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics. 2008;122:e223-31.
Anna Westrup, barnläkare Blekingesjukhuset (personlig kommunikation).
Fotopoulou C, Kretz R, Bauer S, Schefold JC, Schmitz B, Dudenhausen JW et al. Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period. Epilepsy Res. 2009;85:60-4.
Precourt A, Morin C. Use of lamotrigine during breastfeeding: descriptive analysis of our population and report of five cases of premature neonates Abstract. Breastfeed Med. 2011;6 (Suppl 1):S-18.
Clark CT, Klein AM, Perel JM, Helsel J, Wisner KL. Lamotrigine dosing for pregnant patients with bipolar disorder. Am J Psychiatry. 2013;170:1240-7.
Karcirova I, Grundmann M, Brozmanova H. Drug interaction between lamotrigine and valproic acid used at delivery and during lactation - a case report Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.
Karcirova I, Grundmann M, Brozmanova H. Serum levels of lamotrigine in breastfeeding mothers, maternal milk and nursed infants Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.
Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation. Epilepsia 2005;46(5):775-777
Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J et al. Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years. JAMA Pediatr. 2014;168:729-36.
Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M et al. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology. 2010;75:1954-60.
Birnbaum AK, Meador KJ, Karanam A, Brown C, May RC, Gerard EE et al. Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy. JAMA Neurol. 2020;77(4):441-450.
Paulzen M, Stingl JC, Augustin M, Saßmannshausen H, Franz C, Gründer G et al. Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine. Clin Pharmacokinet. 2019;58(4):535-543.
Bedussi F, Relli V, Faraoni L, Eleftheriou G, Giampreti A, Gallo M et al. Normocytic Normochromic Anaemia and Asymptomatic Neutropenia in a 40-Day-Old Infant Breastfed by an Epileptic Mother Treated With Lamotrigine: Infant's Adverse Drug Reaction. J Paediatr Child Health. 2018;54(1):104-105.
Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .
Yashima K, Obara T, Matsuzaki F, Suzuki C, Saeki M, Koyama M et al. Evaluation of the Safety of Taking Lamotrigine During Lactation Period. Breastfeed Med. 2021;16(5):432-438.
Kohn E, Dinavitser N, Berlin M, Brandriss N, Bar-Chaim A, Gueta I et al. Magnitude of Lamotrigine Exposure Through Breastfeeding. Breastfeed Med. 2022;17(4):341-348.
Khosrowshahi EM, Jouyban A, Farajzadeh MA, Tuzen M, Afshar Mogaddam MR, Nemati M. pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk. Bioanalysis. 2021;13(14):1087-1099.
Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .
- Rambeck B, Kurlemann G, Stodieck SR, May TW, Jurgens U. Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child. Eur J Clin Pharmacol 1997;51(6):481-484
- Tomson T, Öhman I, Vitols S. Lamotrigine in pregnancy and lactation: a case report. Epilepsia 1997;38(9):1039-1041
- Öhman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41(6):709-713
- Page-Sharp M, Kristensen JH, Hackett LP, Beran RG, Rampono J, Hale TW et al. Transfer of lamotrigine into breast milk. Ann Pharmacother 2006;40(7-8):1470-1471
- Liporace J, Kao A, DAbreu A. Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav 2004;5(1):102-105
- Ivana K, Milan G, Blanka K, Hana B. Therapeutic monitoring of lamotrigine during delivery, in the neonatal period, and during lactation. Ther Drug Monit 2007;29(4):477
- Gentile S. Lamotrigine in pregnancy and lactation. Arch Womens Ment Health 2005;8(1):57-8.
- Pennell P, Ritchie J, Newport D, Liporace J, Montgomery J, Newman M et al. Pharmacokinetics of lamotrigine excretion into human breast milk. Neurology 2006;66(5;Suppl 2):A72-A73
- Berry DJ. The disposition of lamotrigine throughout pregnancy. Ther Drug Monit 1999;21(4):450
- Öhman I, Tomson T, Vitols S. Lamotrigine (LTG) pharmacokinetics during delivery and lactation. Ther Drug Monit 1999;21(4):478
- Popescu L, Marceanu M, Moleavin I. Withdrawal of lamotrigine caused by sudden weaning of a newborn: a case report. Epilepsia 2005;46(suppl 6):407
- Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009;43:1893-7.
- Newport DJ, Pennell PB, Calamaras MR, Ritchie JC, Newman M, Knight B et al. Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics. 2008;122:e223-31.
- Anna Westrup, barnläkare Blekingesjukhuset (personlig kommunikation).
- Fotopoulou C, Kretz R, Bauer S, Schefold JC, Schmitz B, Dudenhausen JW et al. Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period. Epilepsy Res. 2009;85:60-4.
- Precourt A, Morin C. Use of lamotrigine during breastfeeding: descriptive analysis of our population and report of five cases of premature neonates Abstract. Breastfeed Med. 2011;6 (Suppl 1):S-18.
- Clark CT, Klein AM, Perel JM, Helsel J, Wisner KL. Lamotrigine dosing for pregnant patients with bipolar disorder. Am J Psychiatry. 2013;170:1240-7.
- Karcirova I, Grundmann M, Brozmanova H. Drug interaction between lamotrigine and valproic acid used at delivery and during lactation - a case report Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.
- Karcirova I, Grundmann M, Brozmanova H. Serum levels of lamotrigine in breastfeeding mothers, maternal milk and nursed infants Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.
- Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation. Epilepsia 2005;46(5):775-777
- Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J et al. Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years. JAMA Pediatr. 2014;168:729-36.
- Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M et al. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology. 2010;75:1954-60.
- Birnbaum AK, Meador KJ, Karanam A, Brown C, May RC, Gerard EE et al. Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy. JAMA Neurol. 2020;77(4):441-450.
- Paulzen M, Stingl JC, Augustin M, Saßmannshausen H, Franz C, Gründer G et al. Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine. Clin Pharmacokinet. 2019;58(4):535-543.
- Bedussi F, Relli V, Faraoni L, Eleftheriou G, Giampreti A, Gallo M et al. Normocytic Normochromic Anaemia and Asymptomatic Neutropenia in a 40-Day-Old Infant Breastfed by an Epileptic Mother Treated With Lamotrigine: Infant's Adverse Drug Reaction. J Paediatr Child Health. 2018;54(1):104-105.
- Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .
- Yashima K, Obara T, Matsuzaki F, Suzuki C, Saeki M, Koyama M et al. Evaluation of the Safety of Taking Lamotrigine During Lactation Period. Breastfeed Med. 2021;16(5):432-438.
- Kohn E, Dinavitser N, Berlin M, Brandriss N, Bar-Chaim A, Gueta I et al. Magnitude of Lamotrigine Exposure Through Breastfeeding. Breastfeed Med. 2022;17(4):341-348.
- Khosrowshahi EM, Jouyban A, Farajzadeh MA, Tuzen M, Afshar Mogaddam MR, Nemati M. pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk. Bioanalysis. 2021;13(14):1087-1099.
- Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .
Författare
Klinisk farmakologi, Karolinska Universitetssjukhuset för Hälso- och sjukvårdsförvaltningen, Region Stockholm. Janusmed amning uppdateras kvartalsvis.
Klinisk farmakologi, Karolinska Universitetssjukhuset för Hälso- och sjukvårdsförvaltningen, Region Stockholm. Janusmed amning uppdateras kvartalsvis.För patienter och allmänhet
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Innehållet senast uppdaterat 2024-11-07