11/21/2024

Janusmed amning

Janusmed amning – Lamotrigin 2care4

Janusmed amning tillhandahåller generella rekommendationer om huruvida ett friskt fullgånget spädbarn kan ammas när modern använder olika läkemedel. Observera att prematura och/eller sjuka spädbarn alltid kräver särskilda överväganden. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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2 2
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Lamotrigin

Lamotrigin

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  1. Rambeck B, Kurlemann G, Stodieck SR, May TW, Jurgens U. Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child. Eur J Clin Pharmacol 1997;51(6):481-484

  2. Tomson T, Öhman I, Vitols S. Lamotrigine in pregnancy and lactation: a case report. Epilepsia 1997;38(9):1039-1041

  3. Öhman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41(6):709-713

  4. Page-Sharp M, Kristensen JH, Hackett LP, Beran RG, Rampono J, Hale TW et al. Transfer of lamotrigine into breast milk. Ann Pharmacother 2006;40(7-8):1470-1471

  5. Liporace J, Kao A, DAbreu A. Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav 2004;5(1):102-105

  6. Ivana K, Milan G, Blanka K, Hana B. Therapeutic monitoring of lamotrigine during delivery, in the neonatal period, and during lactation. Ther Drug Monit 2007;29(4):477

  7. Gentile S. Lamotrigine in pregnancy and lactation. Arch Womens Ment Health 2005;8(1):57-8.

  8. Pennell P, Ritchie J, Newport D, Liporace J, Montgomery J, Newman M et al. Pharmacokinetics of lamotrigine excretion into human breast milk. Neurology 2006;66(5;Suppl 2):A72-A73

  9. Berry DJ. The disposition of lamotrigine throughout pregnancy. Ther Drug Monit 1999;21(4):450

  10. Öhman I, Tomson T, Vitols S. Lamotrigine (LTG) pharmacokinetics during delivery and lactation. Ther Drug Monit 1999;21(4):478

  11. Popescu L, Marceanu M, Moleavin I. Withdrawal of lamotrigine caused by sudden weaning of a newborn: a case report. Epilepsia 2005;46(suppl 6):407

  12. Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009;43:1893-7.

  13. Newport DJ, Pennell PB, Calamaras MR, Ritchie JC, Newman M, Knight B et al. Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics. 2008;122:e223-31.

  14. Anna Westrup, barnläkare Blekingesjukhuset (personlig kommunikation).

  15. Fotopoulou C, Kretz R, Bauer S, Schefold JC, Schmitz B, Dudenhausen JW et al. Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period. Epilepsy Res. 2009;85:60-4.

  16. Precourt A, Morin C. Use of lamotrigine during breastfeeding: descriptive analysis of our population and report of five cases of premature neonates Abstract. Breastfeed Med. 2011;6 (Suppl 1):S-18.

  17. Clark CT, Klein AM, Perel JM, Helsel J, Wisner KL. Lamotrigine dosing for pregnant patients with bipolar disorder. Am J Psychiatry. 2013;170:1240-7.

  18. Karcirova I, Grundmann M, Brozmanova H. Drug interaction between lamotrigine and valproic acid used at delivery and during lactation - a case report Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.

  19. Karcirova I, Grundmann M, Brozmanova H. Serum levels of lamotrigine in breastfeeding mothers, maternal milk and nursed infants Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.

  20. Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation. Epilepsia 2005;46(5):775-777

  21. Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J et al. Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years. JAMA Pediatr. 2014;168:729-36.

  22. Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M et al. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology. 2010;75:1954-60.

  23. Birnbaum AK, Meador KJ, Karanam A, Brown C, May RC, Gerard EE et al. Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy. JAMA Neurol. 2020;77(4):441-450.

  24. Paulzen M, Stingl JC, Augustin M, Saßmannshausen H, Franz C, Gründer G et al. Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine. Clin Pharmacokinet. 2019;58(4):535-543.

  25. Bedussi F, Relli V, Faraoni L, Eleftheriou G, Giampreti A, Gallo M et al. Normocytic Normochromic Anaemia and Asymptomatic Neutropenia in a 40-Day-Old Infant Breastfed by an Epileptic Mother Treated With Lamotrigine: Infant's Adverse Drug Reaction. J Paediatr Child Health. 2018;54(1):104-105.

  26. Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .

  27. Yashima K, Obara T, Matsuzaki F, Suzuki C, Saeki M, Koyama M et al. Evaluation of the Safety of Taking Lamotrigine During Lactation Period. Breastfeed Med. 2021;16(5):432-438.

  28. Kohn E, Dinavitser N, Berlin M, Brandriss N, Bar-Chaim A, Gueta I et al. Magnitude of Lamotrigine Exposure Through Breastfeeding. Breastfeed Med. 2022;17(4):341-348.

  29. Khosrowshahi EM, Jouyban A, Farajzadeh MA, Tuzen M, Afshar Mogaddam MR, Nemati M. pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk. Bioanalysis. 2021;13(14):1087-1099.

  30. Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .

  1. Rambeck B, Kurlemann G, Stodieck SR, May TW, Jurgens U. Concentrations of lamotrigine in a mother on lamotrigine treatment and her newborn child. Eur J Clin Pharmacol 1997;51(6):481-484
  2. Tomson T, Öhman I, Vitols S. Lamotrigine in pregnancy and lactation: a case report. Epilepsia 1997;38(9):1039-1041
  3. Öhman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41(6):709-713
  4. Page-Sharp M, Kristensen JH, Hackett LP, Beran RG, Rampono J, Hale TW et al. Transfer of lamotrigine into breast milk. Ann Pharmacother 2006;40(7-8):1470-1471
  5. Liporace J, Kao A, DAbreu A. Concerns regarding lamotrigine and breast-feeding. Epilepsy Behav 2004;5(1):102-105
  6. Ivana K, Milan G, Blanka K, Hana B. Therapeutic monitoring of lamotrigine during delivery, in the neonatal period, and during lactation. Ther Drug Monit 2007;29(4):477
  7. Gentile S. Lamotrigine in pregnancy and lactation. Arch Womens Ment Health 2005;8(1):57-8.
  8. Pennell P, Ritchie J, Newport D, Liporace J, Montgomery J, Newman M et al. Pharmacokinetics of lamotrigine excretion into human breast milk. Neurology 2006;66(5;Suppl 2):A72-A73
  9. Berry DJ. The disposition of lamotrigine throughout pregnancy. Ther Drug Monit 1999;21(4):450
  10. Öhman I, Tomson T, Vitols S. Lamotrigine (LTG) pharmacokinetics during delivery and lactation. Ther Drug Monit 1999;21(4):478
  11. Popescu L, Marceanu M, Moleavin I. Withdrawal of lamotrigine caused by sudden weaning of a newborn: a case report. Epilepsia 2005;46(suppl 6):407
  12. Nordmo E, Aronsen L, Wasland K, Småbrekke L, Vorren S. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother. 2009;43:1893-7.
  13. Newport DJ, Pennell PB, Calamaras MR, Ritchie JC, Newman M, Knight B et al. Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics. 2008;122:e223-31.
  14. Anna Westrup, barnläkare Blekingesjukhuset (personlig kommunikation).
  15. Fotopoulou C, Kretz R, Bauer S, Schefold JC, Schmitz B, Dudenhausen JW et al. Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period. Epilepsy Res. 2009;85:60-4.
  16. Precourt A, Morin C. Use of lamotrigine during breastfeeding: descriptive analysis of our population and report of five cases of premature neonates Abstract. Breastfeed Med. 2011;6 (Suppl 1):S-18.
  17. Clark CT, Klein AM, Perel JM, Helsel J, Wisner KL. Lamotrigine dosing for pregnant patients with bipolar disorder. Am J Psychiatry. 2013;170:1240-7.
  18. Karcirova I, Grundmann M, Brozmanova H. Drug interaction between lamotrigine and valproic acid used at delivery and during lactation - a case report Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.
  19. Karcirova I, Grundmann M, Brozmanova H. Serum levels of lamotrigine in breastfeeding mothers, maternal milk and nursed infants Abstract. Basic Clin Pharmacol Toxicol. 2011;109:134.
  20. Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation. Epilepsia 2005;46(5):775-777
  21. Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J et al. Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years. JAMA Pediatr. 2014;168:729-36.
  22. Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M et al. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology. 2010;75:1954-60.
  23. Birnbaum AK, Meador KJ, Karanam A, Brown C, May RC, Gerard EE et al. Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy. JAMA Neurol. 2020;77(4):441-450.
  24. Paulzen M, Stingl JC, Augustin M, Saßmannshausen H, Franz C, Gründer G et al. Comprehensive Measurements of Intrauterine and Postnatal Exposure to Lamotrigine. Clin Pharmacokinet. 2019;58(4):535-543.
  25. Bedussi F, Relli V, Faraoni L, Eleftheriou G, Giampreti A, Gallo M et al. Normocytic Normochromic Anaemia and Asymptomatic Neutropenia in a 40-Day-Old Infant Breastfed by an Epileptic Mother Treated With Lamotrigine: Infant's Adverse Drug Reaction. J Paediatr Child Health. 2018;54(1):104-105.
  26. Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .
  27. Yashima K, Obara T, Matsuzaki F, Suzuki C, Saeki M, Koyama M et al. Evaluation of the Safety of Taking Lamotrigine During Lactation Period. Breastfeed Med. 2021;16(5):432-438.
  28. Kohn E, Dinavitser N, Berlin M, Brandriss N, Bar-Chaim A, Gueta I et al. Magnitude of Lamotrigine Exposure Through Breastfeeding. Breastfeed Med. 2022;17(4):341-348.
  29. Khosrowshahi EM, Jouyban A, Farajzadeh MA, Tuzen M, Afshar Mogaddam MR, Nemati M. pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk. Bioanalysis. 2021;13(14):1087-1099.
  30. Kacirova I, Grundmann M, Brozmanova H. A Short Communication: Lamotrigine Levels in Milk, Mothers, and Breastfed Infants During the First Postnatal Month . Ther Drug Monit . 2019;3(41):401-404 .

Innehållet senast uppdaterat 11/7/2024