11/15/2026

Janusmed amning

Janusmed amning – Takrolimus - systemiskt

Janusmed amning tillhandahåller generella rekommendationer om huruvida ett friskt fullgånget spädbarn kan ammas när modern använder olika läkemedel. Observera att prematura och/eller sjuka spädbarn alltid kräver särskilda överväganden. Om du inte är medicinskt utbildad, läs först vår information för patienter och allmänhet.

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Takrolimus - systemiskt

Takrolimus - systemiskt

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  1. Gardiner SJ, Begg EJ. Breastfeeding during tacrolimus therapy. Obstet Gynecol 2006;107(2 Pt 2):453-455.

  2. French AE, Soldin SJ, Soldin OP, Koren G. Milk transfer and neonatal safety of tacrolimus. Ann Pharmacother 2003;37(6):815-818.

  3. Zheng S, Easterling TR, Hays K, Umans JG, Miodovnik M, Clark S et al. Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. Br J Clin Pharmacol. 2013;76(6):988-96.

  4. Gouraud A, Bernard N, Millaret A, Bruel M, Paret N, Descotes J et al. Follow-up of tacrolimus breastfed babies. Transplantation. 2012;94(6):e38-40.

  5. Izumi Y, Miyashita T, Migita K. Safety of tacrolimus treatment during pregnancy and lactation in systemic lupus erythematosus: a report of two patients. Tohoku J Exp Med. 2014;234(1):51-6.

  6. Bramham K, Chusney G, Lee J, Lightstone L, Nelson-Piercy C. Breastfeeding and tacrolimus: serial monitoring in breast-fed and bottle-fed infants. Clin J Am Soc Nephrol. 2013;8(4):563-7.

  7. Thiagarajan KM, Arakali SR, Mealey KJ, Cardonick EH, Gaughan WJ, Davison JM et al. Safety considerations: breastfeeding after transplant. Prog Transplant. 2013;23(2):137-46.

  8. Gomez-Lobo V, Landy HJ, Matsumoto C, Fishbein TM. Pregnancy in an intestinal transplant recipient. Obstet Gynecol. 2012;120(1):497-500.

  9. Hiramatsu Y, Yoshida S, Kotani T, Nakamura E, Kimura Y, Fujita D et al. Changes in the blood level, efficacy, and safety of tacrolimus in pregnancy and the lactation period in patients with systemic lupus erythematosus. Lupus. 2018;27(14):2245-2252.

  10. Akamine Y, Fujiyama N, Kagaya H, Saito M, Miura H, Terada Y et al. Tacrolimus concentrations after renal transplantation in a mother-neonate dyad: Maternal, neonatal and breast milk measurements. J Clin Pharm Ther. 2021;46(6):1800-1803.

  11. Nure E, Pascale MM, Frongillo F, Franco A, Bianco G, Agnes S. Pregnancy After Liver Transplant: Neonatal Outcomes and Long-Term Maternal Follow-up. Transplant Proc. 2019;51(9):2948-2951.

  12. Klintmalm GB, Gunby RT. Successful Pregnancy in a Liver Transplant Recipient on Belatacept. Liver Transpl. 2020;26(9):1193-1194.

  13. Koinuma S, Goto M, Fujioka I, et al. Immune function and immunization safety in breastfed infants born to liver transplantrecipients receiving tacrolimus , including sustained-release formulations. Neurotoxicol Teratol. 2026;116:35.

  14. Kuczaj A, Danel A, Warwas S, et al. Toxic milk- should we still be afraid of breastfeeding while on tacrolimus therapy: Acase study. J Heart Lung Transplant 2024;43:S631.

  15. Van Neste M, Nauwelaerts N, de Loor H, et al. Tacrolimus exposure in human milk: Case series from the UmbrelLACTstudy-a contribution from the ConcePTION project. Neurotoxicol Teratol 2025;109 (Suppl 2):25.

  16. Mizutani S, Okunishi Y, Tamada T, Tanaka H, Ito Y, Yamamoto Y et al. A Woman with Rheumatoid Arthritis Who Successfully Delivered a Healthy Child with Continuous Administration of Sarilumab Throughout Pregnancy. Intern Med. 2023;62(4):633-636.

  1. Gardiner SJ, Begg EJ. Breastfeeding during tacrolimus therapy. Obstet Gynecol 2006;107(2 Pt 2):453-455.
  2. French AE, Soldin SJ, Soldin OP, Koren G. Milk transfer and neonatal safety of tacrolimus. Ann Pharmacother 2003;37(6):815-818.
  3. Zheng S, Easterling TR, Hays K, Umans JG, Miodovnik M, Clark S et al. Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. Br J Clin Pharmacol. 2013;76(6):988-96.
  4. Gouraud A, Bernard N, Millaret A, Bruel M, Paret N, Descotes J et al. Follow-up of tacrolimus breastfed babies. Transplantation. 2012;94(6):e38-40.
  5. Izumi Y, Miyashita T, Migita K. Safety of tacrolimus treatment during pregnancy and lactation in systemic lupus erythematosus: a report of two patients. Tohoku J Exp Med. 2014;234(1):51-6.
  6. Bramham K, Chusney G, Lee J, Lightstone L, Nelson-Piercy C. Breastfeeding and tacrolimus: serial monitoring in breast-fed and bottle-fed infants. Clin J Am Soc Nephrol. 2013;8(4):563-7.
  7. Thiagarajan KM, Arakali SR, Mealey KJ, Cardonick EH, Gaughan WJ, Davison JM et al. Safety considerations: breastfeeding after transplant. Prog Transplant. 2013;23(2):137-46.
  8. Gomez-Lobo V, Landy HJ, Matsumoto C, Fishbein TM. Pregnancy in an intestinal transplant recipient. Obstet Gynecol. 2012;120(1):497-500.
  9. Hiramatsu Y, Yoshida S, Kotani T, Nakamura E, Kimura Y, Fujita D et al. Changes in the blood level, efficacy, and safety of tacrolimus in pregnancy and the lactation period in patients with systemic lupus erythematosus. Lupus. 2018;27(14):2245-2252.
  10. Akamine Y, Fujiyama N, Kagaya H, Saito M, Miura H, Terada Y et al. Tacrolimus concentrations after renal transplantation in a mother-neonate dyad: Maternal, neonatal and breast milk measurements. J Clin Pharm Ther. 2021;46(6):1800-1803.
  11. Nure E, Pascale MM, Frongillo F, Franco A, Bianco G, Agnes S. Pregnancy After Liver Transplant: Neonatal Outcomes and Long-Term Maternal Follow-up. Transplant Proc. 2019;51(9):2948-2951.
  12. Klintmalm GB, Gunby RT. Successful Pregnancy in a Liver Transplant Recipient on Belatacept. Liver Transpl. 2020;26(9):1193-1194.
  13. Koinuma S, Goto M, Fujioka I, et al. Immune function and immunization safety in breastfed infants born to liver transplantrecipients receiving tacrolimus , including sustained-release formulations. Neurotoxicol Teratol. 2026;116:35.
  14. Kuczaj A, Danel A, Warwas S, et al. Toxic milk- should we still be afraid of breastfeeding while on tacrolimus therapy: Acase study. J Heart Lung Transplant 2024;43:S631.
  15. Van Neste M, Nauwelaerts N, de Loor H, et al. Tacrolimus exposure in human milk: Case series from the UmbrelLACTstudy-a contribution from the ConcePTION project. Neurotoxicol Teratol 2025;109 (Suppl 2):25.
  16. Mizutani S, Okunishi Y, Tamada T, Tanaka H, Ito Y, Yamamoto Y et al. A Woman with Rheumatoid Arthritis Who Successfully Delivered a Healthy Child with Continuous Administration of Sarilumab Throughout Pregnancy. Intern Med. 2023;62(4):633-636.

Innehållet senast uppdaterat 11/3/2026