11/6/2026

Janusmed sex and gender

Janusmed sex and gender – propranolol hydrochloride

Janusmed Sex and Gender is a knowledge database providing information on sex and gender aspects of drug treatment. The knowledge database is primarily intended to be used by physicians and healthcare professionals. The texts are general and should not be considered as treatment guidelines. The individual patient’s physician is responsible for the patient’s drug treatment.

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Propranolol

Propranolol

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  1. Inderal (propranolol). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2021-11-01, cited 2026-10-07]

  2. Gilmore DA, Gal J, Gerber JG, Nies AS. Age and gender influence the stereoselective pharmacokinetics of propranolol. J Pharmacol Exp Ther. 1992;261(3):1181-6.

  3. Walle UK, Fagan TC, Topmiller MJ, Conradi EC, Walle T. The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers. Br J Clin Pharmacol. 1994;37(1):21-5.

  4. Walle T, Walle UK, Cowart TD, Conradi EC. Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects. Clin Pharmacol Ther. 1989;46(3):257-63.

  5. Walle T, Walle K, Mathur RS, Palesch YY, Conradi EC. Propranolol metabolism in normal subjects: association with sex steroid hormones. Clin Pharmacol Ther. 1994;56(2):127-32.

  6. Xie HG, Chen X. Sex differences in pharmacokinetics of oral propranolol in healthy Chinese volunteers. Zhongguo Yao Li Xue Bao. 1995;16(5):468-70.

  7. el-Yazigi A, el-Baage T, al-Humaidan A, Yusuf A. Steady state pharmacokinetics of propranolol in Saudi Arabian patients and comparison with data for different populations. J Clin Pharmacol. 1990;30(2):144-50.

  8. Gullestad L, Hallen J, Medbø JI, Grønnerød O, Holme I, Sejersted OM. The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women. Br J Clin Pharmacol. 1996;41(1):57-67.

  9. Braca S, Casillo F, Moreira S, Ekizoglu E, Bjork MH, Szewczyk AK et al. Sex-specific management of migraine a systematic review and consensus statement from the European Headache Federation (EHF). J Headache Pain. 2026;27(1):.

  10. Burza MA, Marschall HU, Napoleone L, Molinaro A. The 35-year odyssey of beta blockers in cirrhosis: any gender difference in sight?. Pharmacol Res. 2017;119:20-26.

  11. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2025 [cited 2026-03-20.]

  1. Inderal (propranolol). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2021-11-01, cited 2026-10-07]
  2. Gilmore DA, Gal J, Gerber JG, Nies AS. Age and gender influence the stereoselective pharmacokinetics of propranolol. J Pharmacol Exp Ther. 1992;261(3):1181-6.
  3. Walle UK, Fagan TC, Topmiller MJ, Conradi EC, Walle T. The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers. Br J Clin Pharmacol. 1994;37(1):21-5.
  4. Walle T, Walle UK, Cowart TD, Conradi EC. Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects. Clin Pharmacol Ther. 1989;46(3):257-63.
  5. Walle T, Walle K, Mathur RS, Palesch YY, Conradi EC. Propranolol metabolism in normal subjects: association with sex steroid hormones. Clin Pharmacol Ther. 1994;56(2):127-32.
  6. Xie HG, Chen X. Sex differences in pharmacokinetics of oral propranolol in healthy Chinese volunteers. Zhongguo Yao Li Xue Bao. 1995;16(5):468-70.
  7. el-Yazigi A, el-Baage T, al-Humaidan A, Yusuf A. Steady state pharmacokinetics of propranolol in Saudi Arabian patients and comparison with data for different populations. J Clin Pharmacol. 1990;30(2):144-50.
  8. Gullestad L, Hallen J, Medbø JI, Grønnerød O, Holme I, Sejersted OM. The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women. Br J Clin Pharmacol. 1996;41(1):57-67.
  9. Braca S, Casillo F, Moreira S, Ekizoglu E, Bjork MH, Szewczyk AK et al. Sex-specific management of migraine a systematic review and consensus statement from the European Headache Federation (EHF). J Headache Pain. 2026;27(1):.
  10. Burza MA, Marschall HU, Napoleone L, Molinaro A. The 35-year odyssey of beta blockers in cirrhosis: any gender difference in sight?. Pharmacol Res. 2017;119:20-26.
  11. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2025 [cited 2026-03-20.]