2/9/2026

Janusmed sex and gender

Janusmed sex and gender – elexacaftor

Janusmed Sex and Gender is a knowledge database providing information on sex and gender aspects of drug treatment. The knowledge database is primarily intended to be used by physicians and healthcare professionals. The texts are general and should not be considered as treatment guidelines. The individual patient’s physician is responsible for the patient’s drug treatment.

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Elexacaftor

Elexacaftor

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  1. Assessment report - Kaftrio (ivacaftor/tezacaftor/elexacaftor). European Medicines Agency (EMA) [www]. [cited 2025-12-19].

  2. Socialstyrelsen. Sällsynta hälsotillstånd - cystisk fribros. Socialstyrelsen [www]. [updated 2022-01-21, cited 2025-12-19].

  3. Olesen HV, Pressler T, Hjelte L, Mared L, Lindblad A, Knudsen PK et al. Gender differences in the Scandinavian cystic fibrosis population. Pediatr Pulmonol. 2010;45(10):959-65.

  4. Holtrop M, Cosmich S, Lee M, Keller A, Jain R. Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis. Chest. 2024;166(5):951-962.

  5. Harness-Brumley CL, Elliott AC, Rosenbluth DB, Raghavan D, Jain R. Gender differences in outcomes of patients with cystic fibrosis. J Womens Health (Larchmt). 2014;23(12):1012-20.

  6. Lam GY, Goodwin J, Wilcox PG, Quon BS. Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes. ERJ Open Res. 2021;7(1):.

  7. Wang A, Lee M, Keller A, Jian S, Lowe K, Finklea JD et al. Sex differences in outcomes of people with cystic fibrosis treated with elexacaftor/tezacaftor/ivacaftor. J Cyst Fibros. 2024;23(1):91-98.

  8. Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D et al. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019;381(19):1809-1819.

  9. Terlizzi V, Fevola C, Presti S, Castaldo A, Daccò V, Claut L et al. Reported Adverse Events in a Multicenter Cohort of Patients Ages 6-18 Years with Cystic Fibrosis and at Least One F508del Allele Receiving Elexacaftor/Tezacaftor/Ivacaftor. J Pediatr. 2024;274:114176.

  10. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2024 [cited 2025-04-23.]

  1. Assessment report - Kaftrio (ivacaftor/tezacaftor/elexacaftor). European Medicines Agency (EMA) [www]. [cited 2025-12-19].
  2. Socialstyrelsen. Sällsynta hälsotillstånd - cystisk fribros. Socialstyrelsen [www]. [updated 2022-01-21, cited 2025-12-19].
  3. Olesen HV, Pressler T, Hjelte L, Mared L, Lindblad A, Knudsen PK et al. Gender differences in the Scandinavian cystic fibrosis population. Pediatr Pulmonol. 2010;45(10):959-65.
  4. Holtrop M, Cosmich S, Lee M, Keller A, Jain R. Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis. Chest. 2024;166(5):951-962.
  5. Harness-Brumley CL, Elliott AC, Rosenbluth DB, Raghavan D, Jain R. Gender differences in outcomes of patients with cystic fibrosis. J Womens Health (Larchmt). 2014;23(12):1012-20.
  6. Lam GY, Goodwin J, Wilcox PG, Quon BS. Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes. ERJ Open Res. 2021;7(1):.
  7. Wang A, Lee M, Keller A, Jian S, Lowe K, Finklea JD et al. Sex differences in outcomes of people with cystic fibrosis treated with elexacaftor/tezacaftor/ivacaftor. J Cyst Fibros. 2024;23(1):91-98.
  8. Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D et al. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019;381(19):1809-1819.
  9. Terlizzi V, Fevola C, Presti S, Castaldo A, Daccò V, Claut L et al. Reported Adverse Events in a Multicenter Cohort of Patients Ages 6-18 Years with Cystic Fibrosis and at Least One F508del Allele Receiving Elexacaftor/Tezacaftor/Ivacaftor. J Pediatr. 2024;274:114176.
  10. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2024 [cited 2025-04-23.]