9/4/2025

Janusmed sex and gender

Janusmed sex and gender – chlorzoxazone

Janusmed Sex and Gender is a knowledge database providing information on sex and gender aspects of drug treatment. The knowledge database is primarily intended to be used by physicians and healthcare professionals. The texts are general and should not be considered as treatment guidelines. The individual patient’s physician is responsible for the patient’s drug treatment.

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Chlorzoxazone

Chlorzoxazone

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  1. Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132 Suppl 1:S26-45.

  2. Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52-8.

  3. Sorge RE, Totsch SK. Sex Differences in Pain. J Neurosci Res. 2017;95(6):1271-1281.

  4. Dance A. Why the sexes don't feel pain the same way. Nature. 2019;567(7749):448-450.

  5. Patwardhan V, Gil GF, Arrieta A, Cagney J, DeGraw E, Herbert ME et al. Differences across the lifespan between females and males in the top 20 causes of disease burden globally: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Public Health. 2024;9(5):e282-e294.

  6. Karo Pharma AB. Paraflex Produktresumé. Läkemedelsverket [www]. [updated 2021-01-19, cited 2025-02-07].

  7. Kim RB, O'Shea D. Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin Pharmacol Ther. 1995;57(6):645-55.

  8. Lucas D, Ménez C, Girre C, Berthou F, Bodénez P, Joannet I et al. Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics. 1995;5(5):298-304.

  9. Chen XP, Han XM, Jiang CH, Huang SL, Liu ZQ, Zhu B et al. Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population. Xenobiotica. 2002;32(11):1053-62.

  10. Marchand LL, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev. 1999;8(6):495-500.

  11. Bebia Z, Buch SC, Wilson JW, Frye RF, Romkes M, Cecchetti A et al. Bioequivalence revisited: influence of age and sex on CYP enzymes. Clin Pharmacol Ther. 2004;76(6):618-27.

  12. Vera Regitz-Zagrosek. Sex and Gender Differences in Pharmacology. Springer-Verlag Berlin Heidelberg; 2012.

  13. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2024 [cited 2025-04-23.]

  1. Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132 Suppl 1:S26-45.
  2. Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52-8.
  3. Sorge RE, Totsch SK. Sex Differences in Pain. J Neurosci Res. 2017;95(6):1271-1281.
  4. Dance A. Why the sexes don't feel pain the same way. Nature. 2019;567(7749):448-450.
  5. Patwardhan V, Gil GF, Arrieta A, Cagney J, DeGraw E, Herbert ME et al. Differences across the lifespan between females and males in the top 20 causes of disease burden globally: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Public Health. 2024;9(5):e282-e294.
  6. Karo Pharma AB. Paraflex Produktresumé. Läkemedelsverket [www]. [updated 2021-01-19, cited 2025-02-07].
  7. Kim RB, O'Shea D. Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin Pharmacol Ther. 1995;57(6):645-55.
  8. Lucas D, Ménez C, Girre C, Berthou F, Bodénez P, Joannet I et al. Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics. 1995;5(5):298-304.
  9. Chen XP, Han XM, Jiang CH, Huang SL, Liu ZQ, Zhu B et al. Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population. Xenobiotica. 2002;32(11):1053-62.
  10. Marchand LL, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev. 1999;8(6):495-500.
  11. Bebia Z, Buch SC, Wilson JW, Frye RF, Romkes M, Cecchetti A et al. Bioequivalence revisited: influence of age and sex on CYP enzymes. Clin Pharmacol Ther. 2004;76(6):618-27.
  12. Vera Regitz-Zagrosek. Sex and Gender Differences in Pharmacology. Springer-Verlag Berlin Heidelberg; 2012.
  13. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2024 [cited 2025-04-23.]