5/9/2025

Janusmed sex and gender

Janusmed sex and gender – Isotretinoin

Janusmed Sex and Gender is a knowledge database providing information on sex and gender aspects of drug treatment. The knowledge database is primarily intended to be used by physicians and healthcare professionals. The texts are general and should not be considered as treatment guidelines. The individual patient’s physician is responsible for the patient’s drug treatment.

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C C

Isotretinoin

Isotretinoin

Class : C

  1. Isotretinoin Orifarm (isotretinoin). Summary of Product Characteristics. Swedish Medical Products Agency [updated 2022-10-31, cited 2023-03-07]
  2. Walker BR, MacKie RM. Serum lipid elevation during isotretinoin therapy for acne in the west of Scotland. Br J Dermatol. 1990;122(4):531-7.
  3. Lappas AS, Edwards Suarez L, Tzanetakou V, Morton S, Schofield C, Christodoulou NG. Factors associated with increased suicidality risk following referral for isotretinoin commencement. Australas Psychiatry. 2022;30(1):44-48.
  4. Sundström A, Alfredsson L, Sjölin-Forsberg G, Gerdén B, Bergman U, Jokinen J. Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study. BMJ. 2010;341:c5812.
  5. Droitcourt C, Nowak E, Rault C, Happe A, Le Nautout B, Kerbrat S et al. Risk of suicide attempt associated with isotretinoin: a nationwide cohort and nested case-time-control study. Int J Epidemiol. 2019;48(5):1623-1635.
  6. Medicines and Healthcare Products Regulatory Agency. Review of isotretinoin and psychiatric adverse reactions. Medicines and Healthcare Products Regulatory Agency [www]. [updated 2014-11-01, cited 2023-03-07].
  7. Barbieri JS, Shin DB, Wang S, Margolis DJ, Takeshita J. Association of Race/Ethnicity and Sex With Differences in Health Care Use and Treatment for Acne. JAMA Dermatol. 2020;156(3):312-319.
  8. AlGhamdi KM, Khurram H, Asiri YA, Mandil A. Dermatologists' level of compliance with the prescription guidelines of isotretinoin for females of childbearing potential. Int J Dermatol. 2011;50(9):1094-8.
  9. Statistikdatabas för läkemedel. Stockholm: Socialstyrelsen. 2022 [cited 2023-03-02.]